关键词: 睡眠呼吸暂停综合征, 高血压, 糖尿病, 汉族, 维吾尔族, 随访研究

Abstract: Background　Obstructive sleep apnea（OSA） is highly prevalent，which has become a serious disease affecting public health. There are little data comparing the incidence of hypertension and diabetes in Uygur and Han people with OSA，which we assume to be different. Objective　To perform a comparative analysis of the incidence of hypertension and diabetes in Han and Uygur people with OSA. Methods　This prospective study was conducted from October 2010 to October 2017. Participants（n=1 331） were Han and Uygur Chinese snorers aged more than 35 years with no hypertension and diabetes prior to the study who were selected from Tianshan Community，Karamay. All of them received an annual telephone follow-up in each of the seven years，for investigating the incidence of hypertension and/or diabetes，and the results of ambulatory blood pressure monitoring and oral glucose tolerance test performed when having clinical manifestations of hypertension and diabetes. The primary endpoint was diabetes and/or hypertension. General demographics，and parameters of portable home sleep test（apnea-hypopnea index，hypopnea index，lowest oxygen saturation，and mean oxygen saturation during sleep，and the number of 4% desaturations） were collected. The incidence of hypertension and/or diabetes was compared by OSA（assessed by the portable home sleep test） in all participants，in Han people，and Uygur people，and by OSA and ethnic group in participants. Results　All cases were included for final analysis 〔including 532（42.4%） men and 724（57.6%） women with a mean age of（58±13） years〕 except for 75 missed cases. 820 cases（470 Han and 350 Uygur people） were diagnosed with OSA，and 436（164 Han and 272 Uygur people） without. By the end of the follow-up，compared with those without OSA，participants with OSA had higher incidence of hypertension （P<0.05）. Uygur people with OSA had higher incidence of hypertension than those without（P<0.05）. The incidence of diabetes differed significantly between participants with and without OSA（P<0.05）. But the difference in the incidence of diabetes was not significant between Han people with and without OSA，Uygur people with and without OSA，and Han and Uygur people with OSA（P>0.05）. Conclusion　Both Han and Uygur people with OSA were more likely to suffer from hypertension. OSA may be an independent risk factor for hypertension and diabetes. Han people with OSA were more prone to hypertension than Uygur counterparts，so early and aggressive intervention is needed.

Key words: Sleep apnea syndromes, Hypertension, Diabetes mellitus, Han nationality, Uygur nationality, Follow-up studies