中国全科医学 ›› 2023, Vol. 26 ›› Issue (27): 3335-3341.DOI: 10.12114/j.issn.1007-9572.2022.0688

所属专题: 精神卫生最新文章合集

• 综述与专论 •    下一篇

经颅低水平激光:一种治疗抑郁症的新方法

梁雪梅1, 王睿2,*(), 赵玉环1, 徐天娇2, 王伟3, 孙伟东1   

  1. 1.161006 黑龙江省齐齐哈尔市,齐齐哈尔医学院附属第四医院精神科
    2.161006 黑龙江省齐齐哈尔市,齐齐哈尔医药科学研究所博士后科研工作站
    3.157000 黑龙江省牡丹江市,牡丹江医学院马克思主义学院教研科
  • 收稿日期:2022-08-24 修回日期:2022-11-06 出版日期:2023-09-20 发布日期:2022-11-21
  • 通讯作者: 王睿

  • 作者贡献:梁雪梅负责提出概念、文章框架构思与撰写;王睿负责文章质量控制与审校,对文章负责;赵玉环负责技术与材料支持;徐天娇负责资料收集与整理;王伟、孙伟东负责文章修订。
  • 基金资助:
    齐齐哈尔医学科学院临床科研基金项目(QMSI2020L-05); 黑龙江省自然科学基金面上项目(H2015068)

Transcranial Low-level Laser Therapy: a Novel Treatment for Depression

LIANG Xuemei1, WANG Rui2,*(), ZHAO Yuhuan1, XU Tianjiao2, WANG Wei3, SUN Weidong1   

  1. 1. Department of Psychiatry, the Fourth Affiliated Hospital of Qiqihar Medical University, Qiqihar 161006, China
    2. Postdoctoral Research Station, Qiqihar Institute of Medical and Pharmaceutical Sciences, Qiqihar 161006, China
    3. Department of Teaching and Research, School of Marxism, Mudanjiang Medical University, Mudanjiang 157000, China
  • Received:2022-08-24 Revised:2022-11-06 Published:2023-09-20 Online:2022-11-21
  • Contact: WANG Rui

摘要: 抑郁症作为全球第二大疾病,其病因及发病机制尚未完全明确,现多采用药物治疗、心理治疗和物理治疗等方法,但因药物治疗不良反应大、易复发,心理治疗存在对临床医生专业水平要求较高和物理治疗设备昂贵、定向障碍等缺陷,致使其治疗面临瓶颈。经颅低水平激光在科研实验及临床抗抑郁治疗中均被证明具有疗效。尽管该治疗方法分子及细胞机制尚未确切,但其以非侵入性方式通过颅骨,不对生物体产生损伤,具有光生物学调节效应,对神经元具有保护作用,可以作为一种创新的非药物疗法,为抗抑郁治疗提供新方向。

关键词: 抑郁症, 低强度光疗法, 低水平激光, 线粒体, 神经递质, 神经可塑性, 神经炎症, 综述, 治疗

Abstract:

As the second most serious disease worldwide, the etiology and pathogenesis of depression have not been clearly defined. Depression treatment faces a bottleneck, due to limitations of common therapies, such as side effects associated with drug therapy and high risk of recurrence after drug therapy, high requirements for clinicians to perform psychotherapy, and high cost of modalities and disorientation in physical therapy. Transcranial low-level laser, a new therapy has recently proven to be effective in scientific research and clinical antidepressant treatment, utilizes low-level laser non-invasively passing through the skull without causing damage to regulate biological tissues and protect neurons. Even though the molecular and cellular mechanisms underlying the therapy for depression are not yet clear, this non-drug therapy could be highly promising for depression treatment.

Key words: Depressive disorder, Low-level light therapy, Low-level laser, Mitochondrial, Neurotransmitter, Neuronal plasticity, Neruroinflammation, Review, Therapy