To perform a spatiotemporal analysis of cervical cancer prevalence in Guangdong from 2015 to 2019, providing a decision-making basis for relevant government departments to take targeted prevention and treatment measures for cervical cancer.

In May 2021, data of 5-year (2015—2019) cervical cancer prevalence in 20-64-year-old female Guangdongers living in Guangdong's 21 cities were collected for analysis at the provincial and municipal levels. Average annual growth rate for descriptive analysis. ArcGIS 10.6 was used for spatial visualization, spatial autocorrelation analysis and hot spot analysis (Getis-Ord Gi) .

During 2015—2019, cervical cancer prevalence in Guangdong declined from 50.28/100 000 to 49.84/100 000. The highest average annual growth rate of cervical cancer prevalence was in Meizhou (76.05%), and the lowest was in Chaozhou (-52.81%). In 2019, Jieyang (210.40/100 000) was found to have the highest cervical cancer prevalence, followed by Maoming (127.34/100 000) and Yangjiang (108.05/100 000). In 2018, global spatial correlation (Global Moran's I value=0.364, P<0.05) appeared in the prevalence of cervical cancer in 21 cities in Guangdong, showing the characteristic of aggregated distribution. The results of local spatial autocorrelation indicated that Guangzhou consistently showed the local characteristics of "low-value to low-value agglomeration" from 2015 to 2019, with an expanded scope with the local characteristics overall. Jieyang and Chaozhou were cervical cancer "hot spots" in 2015, 2018 and 2019.

From 2015 to 2019, although Guangdong saw a decrease in cervical cancer prevalence on the whole, it had a higher cervical cancer prevalence in 2019 (43.3/100 000) than the national level. Comparatively speaking, the overall cervical cancer prevalence in Pearl River Delta region was lower than that of eastern, western and northern Guangdong. And cervical cancer "hot spots" were mainly in eastern Guangdong.