关键词: 冠心病, 大蒜辣素, 老年人, 治疗结果, Meta分析

Abstract: Objective　To perform a meta analysis to evaluate the influence of allicin on the clinical effect for coronary heart disease （CHD） in elderly patients.Methods　We searched the following databases：PubMed，EMBase，Cochrane Library，Science Direct，Google Scholar，CNKI，VIP network and the Wanfang Data Knowledge Service Platform.The search cutoff publication date was October 2017.Randomized controlled trials （RCTs） involving the use of allicin in treating elderly individuals with CHD were searched.The included studies underwent quality assessment and data extraction.Stata 11.0 was used for the meta analysis.The evaluated indices included angina remission，total cholesterol （TC），triglyceride （TG），low-density lipoprotein cholesterol （LDL-C），apolipoprotein B （Apo-B），plasma nitric oxide （NO） and blood pressure （BP）.Results　 A total of nine studies involving 574 patients were included.Meta analysis showed no significant difference in angina remission between the two groups〔RR=1.03，95%CI （0.94，1.13），P=0.559〕.The allicin group had a lower TC level than the control group〔SMD=-1.16，95%CI （-2.23，-0.09），P=0.033〕.There was no significant difference in TG level between the two groups〔SMD=0.70，95%CI （-0.74，2.15），P=0.34〕.The level of LDL-C in the allicin group was lower than that in the control group〔SMD=-0.84，95%CI （-1.66，-0.02），P=0.04〕.The level of Apo-B in the allicin group was lower than that in the control group〔SMD=-0.80，95%CI （-1.06，-0.54），P<0.001〕.The allicin group had a higher plasma NO level than did the control group〔SMD=0.71，95%CI （0，1.43），P=0.049〕.The SBP in both groups was not significantly different〔SMD=-1.04，95%CI （-2.64，0.55），P=0.20）〕，nor was the DBP〔SMD=-1.32，95%CI （-2.81，0.16），P=0.08〕.Conclusion　Allicin improves dyslipidemia and increases plasma NO concentrations in elderly patients with CHD.

Key words: Coronary disease, Allicin, Aged, Treatment outcome, Meta-analysis