关键词: 癌, 非小细胞肺；中药注射剂；临床疗效；网状Meta分析；治疗结果

Abstract: Background　Non-small-cell lung cancer（NSCLC） is a common lethal malignancy that places great stress and burden on society and patients.Chinese medicine injection（CMI） combined with paclitaxel and cisplatin chemotherapy has been widely used in the treatment of NSCLC，and has made great progress in synergistic and attenuating，but there is still a lack of direct or indirect comparison between proprietary Chinese medicines.Objective　To systematically evaluate the efficacy and safety of CMI-assisted paclitaxel and cisplatin chemotherapy in the treatment of NSCLC.Methods　The PubMed，Cochrane Library，CNKI，CBM，Wanfang Data Knowledge Service Platform and VIP databases were searched from inception to March 2019 for RCTs about paclitaxel and cisplatin chemotherapy assisted by 8 kinds of CMIs commonly used in clinical practice（Brucea Javanica Oil Emulsion Injection，Aidi Injection，Matrine Injection，Cinobufacini Injection，Delisheng Injection，Xiaoaiping Injection，Kang'ai Injection，Shenqi Fuzheng Injection） in the treatment of NSCLC.Quality evaluation and data extraction were performed on the included RCTs.Mesh analysis was performed using the GeMTC and Stata 14.Results　Finally，10 RCTs and 49 semi-RCTs were included.Network meta-analysis showed that by directly comparing，the case groups treated with either of 5 CMIs（Aidi Injection，Matrine Injection，Xiaoaiping Injection，Kang'ai Injection，and Shenqi Fuzheng Injection） showed better short-term efficacy than the controls（P<0.05）.Moreover，the case groups treated with either of 8 CMIs demonstrated lower incidence of leukopenia（P<0.05）.By indirectly comparing，the case groups treated with either of the CMIs except Brucea Javanica Oil Emulsion Injection and Xiaoaiping Injection showed lower incidence of nausea and vomiting（P<0.05）.And the quality of life impaired by chemotherapy improved more significantly in all CMI-treated groups（P<0.05）.In terms of the probability of improving the short-term effect of chemotherapy，Cinobufacini Injection had highest probability，followed by Xiaoaiping Injection，Kang'ai Injection，Aidi Injection，Shenqi Fuzheng Injection，Matrine Injection，Delisheng Injection，and Brucea Javanica Oil Emulsion Injection.In terms of reducing the possibility of developing chemotherapy-induced leucopenia，Cinobufacini Injection also showed highest probability，followed by Xiaoaiping Injection，Shenqi Fuzheng Injection，Delisheng Injection，Aidi Injection，Brucea Javanica Oil Emulsion Injection，Matrine Injection，and Kang'ai Injection.With regards to reducing the possibility of developing chemotherapy-induced nausea and vomiting，Shenqi Fuzheng Injection demonstrated highest possibility，followed by Delisheng Injection，Xiaoaiping Injection，Cinobufacini Injection，Matrine Injection，Brucea Javanica Oil Emulsion Injection，Kang'ai Injection，and Aidi Injection.In respect of the possibility of improving health-related quality of life impaired by chemotherapy，Kang'ai Injection showed highest possibility，followed by Brucea Javanica Oil Emulsion Injection，Xiaoaiping Injection，Delisheng Injection，Cinobufacini Injection，Aidi Injection，Shenqi Fuzheng Injection，and Matrine Injection.Conclusion　This analysis shows that，in enhancing the clinical effect of anticancer，Cinobufacini Injection and Kang'ai Injection are more effective；Shenqi Fuzheng Injection and Cinobufacini Injection show better effects on reducing the toxic side effects of chemotherapy.And Cinobufacini Injection is recommended as the first choice for adjuvant therapy for paclitaxel and cisplatin chemotherapy for NSCLC for all concerned.

Key words: Carcinoma, non-small cell lung；Clinical efficacy；Traditional Chinese medicine injection；Network meta-analysis；Treatment outcome