关键词: 动脉粥样硬化, NLRP3炎性小体, 炎症

Abstract: NLRP3 inflammasome is a polyprotein complex formed by the activation of pattern recognition receptor.Activated NLRP3 inflammasome can transform pro-caspase-1 into active caspase-1，which promotes the maturation and secretion of IL-1β and IL-18，and then triggers the inflammatory response of the body.Atherosclerosis is the basis of the pathogenesis of cardiocerebral vascular disease，which is a serious threat to human health.Recent studies show that atherosclerosis is a chronic inflammatory reactive disease，inflammasome plays a key role in the inflammatory response of atherosclerosis，and NLRP3 inflammasome is closely related to the formation of atherosclerosis.This article reviews the activation mechanism of NLRP3 inflammasome and its relationship with atherosclerosis.

Key words: Atherosclerosis, NLRP3 inflammasome, Inflammation