Acute mastitis is a common clinical acute suppurative infection of the breast, which is more common in lactating women 3-4 weeks after delivery. Without timely intervention, it can develop into abscess and even sepsis, which seriously affects the physical and mental health of mothers and children. In recent years, simple Western medicine treatment had a certain effect, but there were problems of drug resistance and high recurrence rate. Integrated traditional Chinese and Western medicine can effectively relieve symptoms, shorten the course of disease and reduce the risk of complications through syndrome differentiation and treatment combined with modern medical means, reflecting significant therapeutic advantages. This guideline was based on evidence-based medicine, the latest diagnosis and treatment standards at home and abroad, combined with expert recommendations and opinions, condensed clinical problems, and systematically sorted out the etiology, pathogenesis, diagnostic criteria, integrated traditional Chinese and Western medicine key points of acute mastitis, so as to provide reference for the clinical diagnosis and treatment of acute mastitis with integrated traditional Chinese and Western medicine.