关键词: 脓毒症, 休克, 脓毒性, 心房颤动, 抗心律失常药

Abstract: Sepsis and septic shock often lead to life-threatening multiple organ dysfunction.Atrial fibrillation is one of the most common clinical manifestations in patients with sepsis and septic shock，whose occurrence may be related to factors such as inflammation，autonomic dysfunction，underlying diseases，endotoxin，cardiac dysfunction，and electrolytes，but the internal mechanism is not yet clear，and although there are many medications available for this disease，the particular effective ones are rarely reported in studies.Therefore，new challenges are posed by the pathogenesis of new-onset atrial fibrillation and antiarrhythmic therapy in patients with sepsis and septic shock.

Key words: Sepsis；Shock, septic；Atrial fibrillation；Anti-arrhythmia agents