关键词: 精神分裂症, 计算机辅助, 认知疗法, 认知功能, 自尊, 社会功能

Abstract: Objective　To investigate the effect of computer-assisted cognitive remediation therapy （CCRT） on the improvement of cognitive function，levels of self-esteem and social performance in schizophrenia patients during recovery period.Methods　Eighty-six schizophrenia patients during recovery period from Hangzhou Seventh People's Hospital，Zhejiang Province，were included during March to December 2016 and were randomized into the CCRT group and control group with 43 in each.The previous conventional drug treatment was continued for 8 weeks in both groups，but 8-week CCRT was given to the CCRT group additionally.Before treatment and at the end of 8-week treatment，Wisconsin Card Sorting Test （WCST），Trail Making Test（TMT） and digit span and coding subtests of the Wechsler Adult Intelligence Scale-Revised in China（WAIS-RC） were used to measure the cognitive function，Self Esteem Scale（SES） was employed to measure the level of self-esteem，and Personal and Social Performance Scale （PSP） was adopted to examine the social performance of the patients.Results　Cognitive function：There were no significant differences between the groups in terms of WCST performance （including the mean number of trials，correct classification，perseverative errors，non-perseverative errors，and categories achieved），TMT performance （mean time needed for completing parts A and B of TMT） and scores of digit span and coding subtests of WAIS-RC at baseline（P>0.05）．After 8-week treatment，the CCRT group demonstrated less mean number of trials，more number of correct classification，perseverative and non-perseverative errors，needed shorter mean time for completing parts A and B of TMT，and achieved higher mean score of digit span subtest（P<0.05）．However，both groups still showed similar mean number of categories achieved and mean score of coding （P>0.05）．The level of self-esteem and social performance：The scores of SES and PSP were similar in the two groups at baseline（P>0.05），but after 8-week treatment，both of them were significantly higher in the CCRT group compared with the control group （P<0.05）．Conclusion　CCRT can effectively improve the cognitive function，the level of self-esteem and social performance in schizophrenia patients during recovery period.

Key words: Schizophrenia, Computer-assisted, Cognitive therapy, Cognitive function, Self-esteem, Social performance