关键词: 膳食, 减重, 膳食, 低碳水化合物, 高营养密度食物

Abstract: Background　Practical，effective，and long-term adherence dietary interventions are urgently needed in overweight and obese patients in order to achieve long-term weight control.Objective　To evaluate the effect of the weight loss diet pattern of gradual transition from low-carbohydrate diet to high-nutrient-dense diet in 1-6 months.Methods　We enrolled 145 overweight and obese outpatients who received treatment from Department of Clinical Nutrition，the Second Affiliated Hospital of Guangzhou Medical University during June 2015 to January 2017.The interventions given to them were as follows：carbohydrate intake was limited to 50 g /d in the 1st month，and thereafter the carbohydrate intake gradually increased.Carbohydrate intake was increased to 110 g/d in the 3rd month.Energy intake level for the first 3 months was designed to be 500 kcal/d reduction based on recommended energy consumption calculated by initial resting metabolic rate and activities level.In the 1st and 2nd months of intervention，substitute food was provided instead of conventional staple food.From the 4th to 6th months of intervention，there was no limit for the intake of calories and carbohydrates and education of “high-nutrient-dense foods pagoda” was implemented based on low refined carbohydrate diet.Body weight was measured and recorded at the end of the 1st，3rd，6th months of intervention.Results　Of the participants，93.8%（136/145） completed the 1st month of intervention，their mean body weight decreased by （3.77±1.76） kg compared with before the intervention（tpaired=10.61，P< 0.01），with a success rate of weight loss of 38.2% （52/136）；the success rate of weight loss for all the participants was 35.8%（52/145）．Totaled 74.5%（108/145） of the participants completed the first 3 months of intervention，their mean body weight decreased by （6.67±3.50） kg compared with before the intervention （tpaired= 10.89，P<0.01），with a success rate of weight loss of 80.5%（87/108）；the success rate of weight loss for all the participants was 60.0%（87/145）．A total of 67.6%（98/145） of the participants completed the whole 6-month intervention，their mean body weight decreased by （7.85±4.12） kg compared with before the intervention （tpaired = 4.77，P<0.01），with a success rate of weight loss of 85.7%（84/98）；the success rate of weight loss for all the participants was 57.9%（84/145）．Conclusion　The pattern of gradual transition from low-carbohydrate diet to high-nutrient-dense diet is effective and feasible，which deserves further clinical application.

Key words: Diet, reducing；Diet, low-carbohydrate；High-nutrient-dense foods