关键词: POEMS综合征, 体征和症状, 诊断

Abstract: Objective　To analyze the clinical features of POEMS syndrome for improving early diagnostic rate of POEMS syndrome and to reduce misdiagnosis.Methods　17 patients with POEMS syndrome admitted to the First Affiliated Hospital of Nanchang University from 2008 to 2015 were selected and their clinical features were analyzed,and related literatures were also reviewed.Results　The initial symptoms of 10 patients were numbness,weakness and pain,and 7 patients were bloating.16 patients had polyneuropathy,15 patients electromyography showed slowed motor nerve conduction,normal proximal amplitude and obviously lowered distal amplitude；increased protein could be found through lumbar puncture examination of 5 patients.14 patients had swelled organs,and swelled lymphadenopathy biopsy presented chronic inflammatory reaction or Castleman’ s disease of plasmocyte types.14 patients had endocrine abnormality with manifestation of gonad axis,thyroid axis,hypothalamic pituit-aryadvenal axis and glucose metabolism.4 patients had positive M-protein;12 patients underwent bone marrow aspiration,and the proportion of plasmocyte in bone marrow smears increased with 4 cases.16 patients had skin changes,manifested by skin blackening and redness,tough skin hardening,and pale fingernails.16 patients had increased water-loading with peripheral edema,pleural effusion,ascites and hydropericardium.3 patients had sclerotic bone lesion.ConclusionPOEMS syndrome has complicated clinical features with high misdiagnosis rate.Clinical doctors should raise awareness of the disease and perform careful examinations for suspected patients so as to avoid misdiagnosis.

Key words: POEMS syndrome, Signs and symptoms, Diagnosis