中国全科医学 ›› 2026, Vol. 29 ›› Issue (06): 693-698.DOI: 10.12114/j.issn.1007-9572.2024.0391

所属专题: 心血管最新文章合辑 肥胖最新文章合辑

• 论著 • 上一篇    下一篇

≥60岁人群中国内脏肥胖指数与心血管代谢性共病关系的横断面研究

韩正1,2, 傅方琳1,2, 孙梦1,2, 潘姚佳1,2, 王为强1,*()   

  1. 1.234000 安徽省宿州市,安徽医科大学附属宿州医院(安徽省宿州市立医院)全科医学科
    2.230000 安徽省合肥市,安徽医科大学
  • 收稿日期:2025-01-10 修回日期:2025-04-15 出版日期:2026-02-20 发布日期:2026-01-05
  • 通讯作者: 王为强

  • 作者贡献:

    韩正确定研究目标,并负责研究的设计、实施及论文撰写;韩正、傅方琳负责数据收集、整理、统计分析以及图表绘制;孙梦、潘姚佳参与论文修订;王为强负责文章的质量把控、审查及整体监督管理。

  • 基金资助:
    安徽省科技创新战略与软科学研究专项计划项目(202106f01050042)

A Cross-sectional Study on the Relationship between the Chinese Visceral Adiposity Index and Cardiometabolic Multimorbidity in Individuals Aged 60 and Above

HAN Zheng1,2, FU Fanglin1,2, SUN Meng1,2, PAN Yaojia1,2, WANG Weiqiang1,*()   

  1. 1. Department of General Medicine, Suzhou Hospital Affiliated to Anhui Medical University (Suzhou Municipal Hospital of Anhui Province), Suzhou 234000, China
    2. Anhui Medical University, Hefei 230000, China
  • Received:2025-01-10 Revised:2025-04-15 Published:2026-02-20 Online:2026-01-05
  • Contact: WANG Weiqiang

摘要: 背景 随着中国人口老龄化的加剧及多病共存现象的日益普遍,心血管代谢性共病(CMM)的高风险特征已成为研究的重要领域。中国内脏肥胖指数(CVAI)作为预测心血管疾病的新指标,与CMM的关系目前尚不明确。 目的 探讨≥60岁人群CVAI与CMM风险之间的关系,并评估CVAI在CMM防治中的潜在作用。 方法 基于2017—2021年安徽省心血管疾病高危人群早期筛查与综合干预项目的60 029例受试者数据,分析其人口学信息、心血管健康状况、体格检查及实验室检查指标,计算CVAI。根据CVAI四分位数将不同性别受试者分为4组(男性:T1~T4组;女性F1~F4组),比较不同性别受试者4组基线特征,并采用多因素Logistic回归分析探讨不同性别人群中CVAI与CMM高危风险的关系。通过限制性立方样条(RCS)曲线评估不同性别间CVAI与CMM的关系,确定OR=1为阈值。 结果 60 029例受试者中男27 203例(45.32%)、女32 826例(54.68%)。在不同性别CVAI四分位数组中,年龄、吸烟、饮酒、农村、高中学历、BMI、平均动脉压(MAP)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)及糖尿病、卒中、高血压、缺血性心脏病比例比较,差异均有统计学意义(P<0.05)。在女性中,CVAI四分位数组高血压用药史比例比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,与T1(F1)组相比,T2~T4(F2~F4)组CMM风险增加(P<0.05)。在完全调整混杂因素后,T4组男性(OR=2.335,95%CI=1.741~3.180,P<0.001)和F4组女性(OR=2.075,95%CI=1.678~2.686,P<0.001)均表现出最高的CMM风险。各组不同性别间CMM风险比较,差异均无统计学意义(P>0.05)。控制不同的混杂因素后,RCS曲线显示,男性CVAI与CMM风险呈非线性关系,且OR=1的阈值为94.75;女性CVAI与CMM风险呈线性关系,且OR=1的阈值为114.87。 结论 高水平CVAI可能与CMM风险密切相关,且在不同性别中CVAI预测CMM的效能一致。应特别关注CVAI超过94.75的男性和超过114.87的女性以降低CMM风险。

关键词: 心血管代谢性共病, 中国内脏肥胖指数, 内脏肥胖指标, 肥胖症, 安徽省, 横截面研究

Abstract:

Background

With the aging of the population and the increasing prevalence of multimorbidity in China, the high-risk characteristics of cardio-metabolic multimorbidity (CMM) have become an important research field. The exact nature of the relationship between the Chinese visceral adiposity index (CVAI) and CMM remains to be elucidated.

Objective

This study aims to investigate the relationship between the CVAI and the high risk of CMM, and to evaluate the potential role of CVAI in the prevention and treatment of CMM in the elderly in China.

Methods

This study was based on the data of 60 029 subjects from the Early Screening and Comprehensive Intervention of High-risk Populations of Cardiovascular Disease in Anhui Province from 2017 to 2021. The demographic information, cardiovascular health status, physical examination and biochemical indicators were analyzed, and the CVAI index was calculated. The subjects were grouped according to the quartile of CVAI (male: T1-T4 group, female: F1-F4 group), and the differences in baseline characteristics were compared. Multtivariate Logistic regression analysis was used to explore the relationship between CVAI and the high risk of CMM. The nonlinear relationship between CVAI and CMM between different genders was assessed by restricted cubic spline (RCS) curves, and a threshold of OR=1 was determined.

Results

There were 60 029 subjects, including 27 203 males (45.32%) and 32 826 females (54.68%). There were statistically significant differences in age, smoking, drinking, rural area, high school education, BMI, mean arterial pressure (MAP), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), fasting plasma glucose (FPG), diabetes, stroke, hypertension, and ischemic heart disease in CVAI quartiles between different genders (P<0.05). There was no significant difference in the history of hypertension medication among males. In women, the difference in medication history of hypertension was statistically significant multivariate. Multtivariate Logistic regression analysis showed that compared with T1 (F1) group, the risk of CMM was significantly increased in T2 toT4 (F2 to F4 ) group. After fully adjusting for confounding factors, the T4 (F4) group showed the highest risk of CMM in both sexes, male (OR=2.335, 95%CI=1.741-3.180, P<0.001), and female (OR=2.735, 95%CI=1.778-2.686, P<0.001). There was no significant difference in the odds ratio between different genders. There was no significant difference in the risk of CMM between males in T4 group and females in F4 group (P>0.05). After controlling for different confounding factors, RCS curve suggested that there was a nonlinear relationship between CVAI index and CMM risk in men, and the threshold of OR=1 was 94.75. There was a linear relationship between CVAI index and CMM risk in women, and the threshold of OR=1 was 114.87.

Conclusion

High level of CVAI may be closely related to the risk of CMM, and the predictive power is consistent in different genders. Special attention should be paid to men with CVAI over 94.75 and women with CVAI over 114.87 to reduce the risk of CMM.

Key words: Cardiometabolic multimorbidity, Chinese visceral adiposity index, Visceral obesity indicator, Obesity, Anhui Province, Cross-sectional study

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