基于肠道干细胞探讨肠神经系统调节肠道炎症的机制研究进展

doi:10.12114/j.issn.1007-9572.2023.0245

摘要/Abstract

摘要： 肠道干细胞受到肠神经系统调控，肠道干细胞与肠神经系统均与肠道炎症存在密切联系。相关研究表明肠道炎症中存在肠神经功能障碍，本文通过总结肠道干细胞、肠神经系统与肠道炎症三者之间的关系，探讨肠道炎症相关的肠神经系统损伤可能是肠道功能持续改变的基础，而肠神经元等为改善肠道炎症性疾病中出现的肠神经功能障碍提供了可行靶点，以期将多种类型干细胞用于改善肠道炎症中出现的肠神经功能障碍。

关键词: 肠道炎症, 炎性肠疾病, 干细胞, 肠神经系统, 治疗, 综述

Abstract:

Intestinal stem cells are regulated by the intestinal nervous system, and both of them are closely related to intestinal inflammation. Relevant studies have shown the existence of intestinal nerve dysfunction in intestinal inflammation. By summarizing the relationship among intestinal stem cells, intestinal nervous system and intestinal inflammation, this paper discusses that intestinal nervous system injury related to intestinal inflammation may be the basis for persistent alteration of intestinal function, while enteric neurons provide feasible targets for improving intestinal nerve dysfunction in inflammatory bowel diseases, so as to apply various types of stem cells to the improvement of intestinal nerve dysfunction in intestinal inflammation.

Key words: Intestinal inflammation, Inflammatory bowel diseases, Stem cell, Enteric nervous system, Therapy, Review

中图分类号:

R 574

陈思琪,肖瑾,田思雨,等. 基于肠道干细胞探讨肠神经系统调节肠道炎症的机制研究进展[J]. 中国全科医学, 2024, 27(23): 2858-2863. DOI: 10.12114/j.issn.1007-9572.2023.0245.
CHEN Siqi,XIAO Jin,TIAN Siyu, et al. Progress of Research on Mechanism of Intestinal Nervous System Regulating Intestinal Inflammation Based on Intestinal Stem Cells[J]. Chinese General Practice, 2024, 27(23): 2858-2863. DOI: 10.12114/j.issn.1007-9572.2023.0245.

图/表 2

图1 ISC与肠道炎症相关性注：ISC=肠道干细胞，AHR=环境传感器芳香烃受体，WFDC2=WAP四二硫化物核心域蛋白2，ERVs=内源性逆转录病毒，SETDB1=组蛋白赖氨酸甲基转移酶，ZBP1=Z-DNA结合蛋白1，RIP3=受体相互作用蛋白激酶3，MLKL=混合谱系激酶结构域样蛋白。

Figure 1 Correlation between ISC and intestinal inflammation

图2 ENS与肠道炎症相关性注：ENS=肠神经系统，EGC=肠神经胶质细胞，IEB=肠上皮屏障，VNS=迷走神经刺激，NK-1=神经激肽1，VIP=血管活性肠肽，Ang Ⅱ=血管紧张素Ⅱ，AT1受体=血管紧张素Ⅱ受体。

Figure 2 Correlation between ENS and intestinal inflammation

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