中国全科医学 ›› 2022, Vol. 25 ›› Issue (09): 1047-1053.DOI: 10.12114/j.issn.1007-9572.2021.02.096

所属专题: 胰腺炎最新文章合集

• 最佳证据 • 上一篇    下一篇

胰腺切除患者围术期血糖管理的最佳证据总结

崔蕾1, 刘玲珑2, 王剑剑1, 俞惠萍1, 孙青美1, 苗毅1, 方小萍1,*   

  1. 1210009 江苏省南京市,南京医科大学第一附属医院胰腺中心
    2210009 江苏省南京市,南京医科大学护理学院
  • 收稿日期:2021-08-15 修回日期:2021-10-20 出版日期:2022-03-20 发布日期:2022-03-01
  • 通讯作者: 方小萍
  • 基金资助:
    国家自然科学基金资助项目(81672449)

Best Evidence Summary for Perioperative Blood Glucose Management in Patients Undergoing Pancreatectomy

CUI Lei1LIU Linglong2WANG Jianjian1YU Huiping1SUN Qingmei1MIAO Yi1FANG Xiaoping1*   

  1. 1.Pancreas Centerthe First Affiliated Hospital with Nanjing Medical UniversityNanjing 210009China

    2.School of NursingNanjing Medical UniversityNanjing 210009China

    *Corresponding authorFANG XiaopingChief superintendent nurseE-mailfxp84284@163.com

  • Received:2021-08-15 Revised:2021-10-20 Published:2022-03-20 Online:2022-03-01

摘要: 背景血糖紊乱是胰腺切除患者围术期常见问题。然而,目前国内开展的胰腺切除患者围术期血糖管理实践多以经验为指导,缺乏循证依据。目的总结胰腺切除患者围术期血糖管理的最佳证据。方法系统检索BMJ最佳临床实践、Up to Date、国际指南协作组、国际糖尿病联盟(IDF)、世界卫生组织(WHO)、美国国立指南数据库(NGC)、美国糖尿病协会、英国国家临床优化研究所(NICE)、新西兰指南研究组、加拿大糖尿病协会、澳大利亚糖尿病协会、苏格兰校际指南网络(SIGN)、PubMed、Web of Science、EMBase、CINHAL数据库、Cochrane图书馆、乔安娜布里格斯研究所(JBI)循证卫生保健中心、医脉通、万方数据知识服务平台、中国知网(CNKI)、生物医学数据库(CBM),筛选关于胰腺切除患者围术期血糖管理的文献。检索时间为建库至2020年12月。指南的质量评价采用国际AGREE协作组织2009年更新的AGREE Ⅱ量表。专家共识的质量评价采用澳大利亚JBI循证卫生保健中心专家共识评价标准2017版。随机对照试验的评价采用Jadad评分量表。结果通过初步检索筛选出文献6 637篇,最终纳入文献13篇,其中7篇为临床实践指南,4篇为专家共识,2篇为随机对照试验。评价结果显示,7篇临床实践指南中3篇总体质量评价为A级,剩下4篇为B级;4篇专家共识的质量评价在"观点与其他文献不一致的地方是否有合理解释?"条目的评价结果为"不清楚",其余条目的评价结果均为"是"。2篇随机对照试验均为高质量文献。共汇总了62条最佳证据,主要涉及围术期组织管理、入院评估及处理、血糖控制目标、血糖监测、术前血糖管理策略、术中血糖管理策略、术后血糖管理策略、危急状况处理以及出院指导9个方面。结论临床医务人员应根据总结的9个方面最佳证据(包括围术期组织管理、入院评估及处理、血糖控制目标、血糖监测、术前血糖管理策略、术中血糖管理策略、术后血糖管理策略、危急状况处理以及出院指导)为胰腺切除患者制定个体化、全程化的围术期血糖管理方案。

关键词: 胰腺肿瘤, 胰腺切除术, 围手术期, 血糖, 循证医学, 围手术期护理

Abstract: Background

Blood glucose disorder is a common perioperative problem in patients with pancreatectomy. However, current perioperative blood glucose management for pancreatic resection patients in China is mostly based on experience and lack of evidence-based basis.

Objective

To summarize the best evidence for perioperative blood glucose management in patients undergoing pancreatectomy.

Methods

A systematic literature search of BMJ Best Practice, Up to Date, Guideline International Network, International Diabetes Federation, World Health Organization, National Guideline Clearinghouse, American Diabetes Association, the National Institute for Health and Care Excellence, New Zealand Guidelines Group, Canadian Diabetes Association, Australian Diabetes Society, Scottish Intercollegiate Guidelines Network, PubMed, Web of Science, EMBase, CINAHL Database, Cochrane Library, the Joanna Briggs Institute Evidence-based Health Care Center, Medlive.cn, Wanfang Data, CNKI, and Chinese Biomedical Database was conducted to screen the literature on perioperative blood glucose management in patients with pancreatectomy published from inception to December 2020. The AGREE Ⅱ scale updated in 2009 by the International AGREE Collaboration Organization was used to assess the quality of guidelines. The quality assessment of the expert consensus used the 2017 version of the expert consensus evaluation standard of the Australian JBI Evidence-based Health Care Center. The Jadad scale was used to assess the quality of randomized controlled trials (RCTs) .

Results

A total of 6 637 studies were retrieved, and 13 of them were finally included, of which 7 were clinical practice guidelines, 4 were expert consensus, and 2 were RCTs. The results of quality assessment showed that 3 of the 7 clinical practice guidelines were rated grade A, and the remaining 4 were rated grade B. In assessing the quality of the 4 expert consensuses, the answers of raters for all items were "yes" , except that their answers for the item "Is there a reasonable explanation for the point of view inconsistent with other literature?" were "unclear" . Both the two RCTs were rated high. A total of 62 pieces of best evidence were collected, mainly related to perioperative organization and management, admission evaluation and treatment, blood glucose control goals, blood glucose monitoring, preoperative, intraoperative and postoperative blood glucose management strategies, management of emergency conditions, and discharge guidance.

Conclusion

Clinical medical workers can develop individualized and holistic perioperative blood glucose management plans for patients with pancreatectomy, based on the above-mentioned 9 aspects of best evidence.

Key words: Pancreatic neoplasms, Pancreatectomy, Perioperative period, Blood glucose, Evidence-based medicine, Perioperative nursing

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