关键词: 轻度认知障碍, 老年人, 老年综合评估, 简明精神病状态评定量表, 痴呆, 阿尔茨海默病

Abstract: Background　Cognitive function is an important factor affecting people's function and quality of life.In the process of aging，cognitive function will decline.Some people may have mild cognitive impairment（MCI），even dementia.Rationalizing Comprehensive Geriatric Assessment （CGA），screening MCI and multidimensional analysis of the disease are conducive to treat the disease timely，slow down the progress of the disease and reduce dementia.Objective　To take rational comprehensive geriatric assessment screening for mild cognitive impairment，and multidimensional analysis condition.Methods　We enrolled 225 inpatients aged >60 years in Chengdu Fifth People's Hospital from November 2015 to May 2016.According to 2018 Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Impairment in China （V）：Diagnosis and Treatment of Mild Cognitive Impairment，the study subjects were divided into 65 cases of normal cognitive function group and 108 cases of MCI group （the other 52 cases did not exclude the possibility of dementia and were not included）．The basic data of patients were collected，including sex，age，educational level，smoking and alcohol consumption．They were surveyed by a suit of scales of comprehensive geriatric assessment，including Geriatric Depression Scale（GDS），Geriatric Anxiety Inventory（GAI），Mini Nutrition Assessment（MNA），Activities of Daily Living（ADL）〔including Physical Self-maintenance Scale（PSMS）Instrumental Activities of Daily Living（IADL）〕，Frail Scale（FRAIL），Berg Balance Scale（BBS），Fall Risk Assessment，Family APGAR Index （APGAR），Pittsburgh Sleep Quality Index（PSQI），and the Short-Form Health Survey Questionnaire（SF-36）．The correlation between the scores of Mini-Mental State Exam（MMSE） and the basic data was analyzed and comprehensive geriatric assessment scales were compared between the two groups.Results　Multipe linear regression analysis showed that there was no line correlation between gender，age，educational level，daily smoking，daily drinking and cognitive function（P>0.05）．The scores of MNA and Berg balance scale in MCI group were lower than those in normal cognitive function group，while the scores of ADL，IADL and FRAIL in MCI group were higher than those in normal cognitive function group（P<0.05）．Conclusion　Patients over 60 years should take rational CGA，screen MCI，and multidimensionally analyse the condition，identify and reduce reversible factors，help MCI transform into normal cognitive function，and reduce the incidence of dementia.

Key words: Mild cognitive impairment, Aged, Comprehensive geriatric assessment, Brief psychiatric rating scale, Dementia, Alzheimer disease