中国全科医学 ›› 2019, Vol. 22 ›› Issue (21): 2557-2563.DOI: 10.12114/j.issn.1007-9572.2019.00.070

所属专题: 精神卫生最新文章合集

• 专题研究 • 上一篇    下一篇

北京市2型糖尿病患者抑郁情况及其影响因素分析

武钰翔1,程玉霞2,李丽君2,贾军宏3,王闻博4,郭晓蕙5,吴艳巧6,李玉凤7,刘彦君2,王爱红1,2*   

  1. 1.100101北京市,安徽医科大学中国人民解放军第306医院临床学院 2.100101北京市,中国人民解放军第306医院内分泌科 3.100853北京市,中国人民解放军总医院第四医学中心内分泌科 4.100144北京市,北京大学首钢医院内分泌科 5.100034北京市,北京大学第一医院内分泌科 6.100083北京市,中国石油勘探开发研究院 7.101200北京市平谷区医院内分泌科
    *通信作者:王爱红,副教授,副主任医师;E-mail:13671365441@139.com
  • 出版日期:2019-07-20 发布日期:2019-07-20
  • 基金资助:
    基金项目:首都临床特色应用研究与成果推广(Z161100000516010)

Prevalence of Depression and Influencing Factors in Patients with Type 2 Diabetes:a Multi-center Study in Beijing,China 

WU Yuxiang1,CHENG Yuxia2,LI Lijun2,JIA Junhong3,WANG Wenbo4,GUO Xiaohui5,WU Yanqiao6,LI Yufeng7,LIU Yanjun2,WANG Aihong1,2*   

  1. 1.Clinical Medicine College of 306th Hospital of PLA,Anhui Medical University,Beijing 100101,China
    2.Department of Endocrinology,306th Hospital of PLA,Beijing 100101,China
    3.Department of Endocrinology,Fourth Medical Center of PLA General Hospital,Beijing 100853,China
    4.Department of Endocrinology,Peking University Shougang Hospital,Beijing 100144,China
    5.Department of Endocrinology,Peking University First Hospital,Beijing 100034,China
    6.Research Institute of Petroleum Exploration & Development,Beijing 100083,China
    7.Department of Endocrinology,Beijing Pinggu Hospital,Beijing 101200,China
    *Corresponding author:WANG Aihong,Associate professor,Associate chief physician;E-mail:13671365441@139.com
  • Published:2019-07-20 Online:2019-07-20

摘要: 背景 随着糖尿病患病率的逐年增加,糖尿病合并抑郁患者也在逐渐增加,抑郁不仅影响患者的生活质量,同时不利于糖尿病病情控制。目的 调查北京市2型糖尿病患者抑郁发生情况,并分析其影响因素。方法 2016—2017年,选取随机工作日于北京市6家医院(中国人民解放军第306医院、中国人民解放军总医院第四医学中心、北京大学首钢医院、北京大学第一医院、中国石油勘探开发研究院、北京市平谷区医院)门诊就诊及住院的2型糖尿病患者进行问卷调查。调查问卷包括一般资料调查表〔包括社会人口学特征、就诊方式、每年就诊次数、近3年住院次数、生活满意度、糖尿病病程、体质指数(BMI)、血压、空腹血糖、糖化血红蛋白(HbA1c)、降糖治疗情况、合并症、糖尿病并发症〕和抑郁调查表〔病人健康问卷抑郁量表(PHQ-9)联合汉密尔顿抑郁量表(HAMD-17)〕。 计算患者抑郁患病率,并采用单因素、多因素Logistic回归分析研究2型糖尿病患者发生抑郁的影响因素。结果 共发放调查问卷635份,回收有效问卷615份,有效回收率为96.85%。615例患者中抑郁151例(24.55%),非抑郁464例(75.45%)。抑郁患者与非抑郁患者性别、文化程度、职业、家庭人均月收入、就诊方式、近3年住院次数、生活满意度、收缩压、降糖治疗情况、心血管病史合并情况、脑血管病史合并情况、糖尿病视网膜病变并发情况、糖尿病周围神经病变并发情况、糖尿病肾病并发情况、糖尿病下肢血管病变并发情况、糖尿病足并发情况比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,性别〔女性:OR=2.072,95%CI(1.316,3.262),P<0.05〕、家庭人均月收入〔>1 500~3 000元:OR=0.201,95%CI(0.077,0.522),P<0.05;>3 000~5 000元:OR=0.172,95%CI(0.072,0.413),P<0.05;>5 000~10 000元:OR=0.365,95%CI(0.160,0.835),P<0.05;>10 000元:OR=0.154,95%CI(0.055,0.429),P<0.05〕、就诊方式〔住院:OR=2.592,95%CI(1.613,4.166),P<0.05〕、生活满意度〔OR=0.980,95%CI(0.968,0.993),P<0.05〕、空腹血糖〔OR=1.084,95%CI(1.018,1.154),P<0.05〕、心血管病史〔OR=1.642,95%CI(1.006,2.682),P<0.05〕、糖尿病周围神经病变〔OR=3.758,95%CI(2.246,6.287),P<0.05〕是2型糖尿病患者发生抑郁的独立影响因素。结论 北京市2型糖尿病患者抑郁患病率为24.55%,应积极对2型糖尿病患者进行心理筛查,特别是女性、低收入、住院、生活满意度低、空腹血糖控制不达标、有心血管病史和发生糖尿病周围神经病变的2型糖尿病患者。

关键词: 糖尿病, 2型;抑郁;多中心研究;影响因素分析;北京市

Abstract: Background The prevalence of depression is increasing in the growing diabetic patients.Depression is a mental disorder that not only affects the quality of life,but also is not conducive to the control of diabetes mellitus.Objective To investigate the prevalence and influencing factors of depression in type 2 diabetes mellitus (T2DM) patients in Beijing.Methods From the year 2016 to 2017,we conducted surveys among T2DM outpatients and inpatients in 6 hospitals in Beijing (306th Hospital of PLA,Fourth Medical Center of PLA General Hospital,Peking University Shougang Hospital,Peking University First Hospital,Research Institute of Petroleum Exploration & Development and Beijing Pinggu Hospital).We used questionnaires in the surveys,which include a general personal information form 〔sociodemographic characteristics,visiting method,number of annual visits,number of hospitalizations in the past 3 years,satisfaction with life quality,duration of T2DM,body mass index (BMI),blood pressure,fasting blood glucose(FBG),glycosylated hemoglobin (HbA1c),hypoglycemic treatment,comorbidities,diabetic complications〕 and two depression scales〔Patient Health Questionnaire Depression Scale (PHQ-9) combined with Hamilton Depression Rating Scale (HAMD-17)〕.The prevalence of depression was evaluated,and the influencing factors were analyzed by univariate and multivariate Logistic regression analysis.Results A total of 635 patients participated in the survey,and 615 of them responded effectively,achieving a response rate of 96.85%.Among the respondents,151(24.55%) were found with depression,and other 464 without(75.45%).There were significant differences between the depressed and non-depressed respondents in gender ratio,education level,occupation,average monthly household income per person,visiting method,number of hospitalizations in the past 3 years,satisfaction with life quality,systolic blood pressure,hypoglycemic treatment,prevalence of coexistence of cardiovascular disease history,and cerebrovascular disease history,prevalence of diabetic retinopathy,diabetic peripheral neuropathy(DPN),diabetic nephropathy,diabetic angiopathy of lower extremities,and diabetic foot(P<0.05).Multivariate Logistic regression analysis showed that gender 〔female:OR=2.072,95%CI (1.316,3.262),P<0.05〕,average monthly household income per person 〔>1 500-3 000 yuan:OR=0.201,95%CI (0.077,0.522),P<0.05;>3 000-5 000 yuan:OR=0.172,95%CI (0.072,0.413),P<0.05;>5 000-10 000 yuan:OR=0.365,95%CI(0.160,0.835),P<0.05;>10 000 yuan:OR=0.154,95%CI (0.055,0.429),P<0.05〕,visiting method 〔hospitalization:OR=2.592,95%CI (1.613,4.166),P<0.05 〕,satisfaction with life quality〔OR=0.980,95%CI (0.968,0.993),P<0.05〕,FBG〔OR=1.084,95%CI (1.018,1.154),P<0.05〕,history of cardiovascular disease 〔OR=1.642,95%CI (1.006,2.682),P<0.05〕,DPN 〔OR=3.758,95%CI (2.246,6.287),P<0.05〕,were independent influencing factors of depression in T2DM.Conclusion The prevalence of depression in T2DM patients was 24.55% in Beijing.So psychological screening should be actively conducted in this population,especially those who are women,have low income,a hospitalization,poor level of satisfaction with life quality,poor glycemic control,a history of cardiovascular disease or DPN.

Key words: Diabetes mellitus, type 2;Depression;Multicenter study;Root cause analysis;Beijing