中国全科医学

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慢病管理创新实践:糖肝全-专管理新模式

白雪, 陈倩倩, 李婕*   

  1. 南京大学医学院附属鼓楼医院感染性疾病科
    南京中医药大学鼓楼临床医学院感染性疾病科
  • 收稿日期:2025-02-13 接受日期:2025-04-01
  • 通讯作者: 李婕
  • 基金资助:
    国家自然科学基金面上项目(82170609); 国家自然科学基金面上项目(81970545); 国家自然科学基金国际(地区)合作与交流项目(82411560273); 国家科技创新2030重大专项(2023ZD0508802); 江苏省自然科学基金面上项目(BK20231118)

Innovative Practices in Chronic Disease Management: A New Model for Total-Specialized Management of Diabetes and Metabolic Dysfunction-Associated Fatty Liver Disease

BAI Xue, CHEN Qianqian,LI Jie1*   

  • Received:2025-02-13 Accepted:2025-04-01
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摘要: 由非酒精性脂肪性肝病(NAFLD)到如今的代谢相关脂肪性肝病(MAFLD),诊断名词的不断规范,意在突出“代谢紊乱”在脂肪性肝病的发生发展中的重要作用,而2型糖尿病作为全球最常见的代谢性疾病之一,目前也被认为是MAFLD的最常见的合并症,两者之间相互影响,加速疾病进展,导致肝内肝外不良结局。面对此状况,亟需充分发挥“整体医学观”,探索基于糖尿病的脂肪肝全周期、全方位管理新模式对于改善糖尿病和脂肪肝患者的预后具有重要意义。本文总结MAFLD和T2DM共病的流行病学和发病机制、分享基于“糖肝共管”理念提出的全-专管理新模式的创新实践。

关键词: 代谢相关脂肪性肝病, 2型糖尿病, 临床管理

Abstract: The evolution of diagnostic term from non-alcoholic fatty liver disease (NAFLD) to the metabolic dysfunction-associated fatty liver disease (MAFLD) aims to highlight the critical role of "metabolic dysfunction" in the development and progression of fatty liver diseases. As one of the most common metabolic disorders globally, type 2 diabetes mellitus (T2DM) is now considered as the most common complication of MAFLD. The two diseases interact in ways that adversely affect various systems within the body In addressing this situation, we urgently need to leverage a "holistic medical perspective", targeting comprehensive health outcomes for patients by integrating interdisciplinary management strategies for the joint administration of MAFLD and T2DM. This approach facilitates the exploration of a new model for the full-cycle, all-dimensional management of fatty liver disease based on diabetes.

Key words: Metabolic dysfunction-associated fatty liver disease, Type 2 diabetes mellitus, Clinical management