中国全科医学 ›› 2026, Vol. 29 ›› Issue (10): 1246-1249.DOI: 10.12114/j.issn.1007-9572.2025.0433

• 世界全科医学工作研究 • 上一篇    下一篇

澳大利亚全科医生学会《全科医学的预防活动指南》解读和讨论:乳糜泻筛查和病例发现的双重策略及对我国全科实践的启示

邱珊娇1, 陈章2, 李安春3, 何智光4, 黄文静5,*()   

  1. 1.518000 广东省深圳市,罗湖医院集团黄贝岭社区健康服务中心
    2.518000 广东省深圳市,罗湖医院集团南湖街道社区健康服务中心
    3.518000 广东省深圳市,罗湖医院集团笋岗街道社区健康服务中心
    4.518000 广东省深圳市,罗湖医院集团金鹏社区健康服务中心
    5.518000 广东省深圳市,罗湖医院集团居民健康管理中心(社管中心)
  • 收稿日期:2025-11-15 修回日期:2026-01-12 出版日期:2026-04-05 发布日期:2026-03-25
  • 通讯作者: 黄文静

  • 作者贡献:

    邱珊娇负责研究的整体构思及设计、文献检索、资料整理与论文初稿撰写及修订;陈章、李安春、何智光参与研究思路讨论,协助文献检索与资料整理,对论文形成提供支持与修订意见;黄文静负责内容把关,对文章的学术质量和完整性负责。作者均已阅读并批准提交的最终稿,并对研究内容的真实性和可靠性负责。

Screening and Case Finding for Coeliac Disease: Lessons for Chinese General Practice from the RACGP Guidelines of Preventive Activities

QIU Shanjiao1, CHEN Zhang2, LI Anchun3, HE Zhiguang4, HUANG Wenjing5,*()   

  1. 1. Huangbeiling Community Health Centre of Luohu Hospital Group, Shenzhen 518000, Chnia
    2. Nanhu Subdistrict Community Health Centre of Luohu Hospital Group, Shenzhen 518000, Chnia
    3. Sungang Subdistrict Community Health Centre of Luohu Hospital Group, Shenzhen 518000, Chnia
    4. Jinpeng Community Health Centre of Luohu Hospital Group, Shenzhen 518000, Chnia
    5. Resident Health Management Center, Luohu Hospital Group, Shenzhen 518000, Chnia
  • Received:2025-11-15 Revised:2026-01-12 Published:2026-04-05 Online:2026-03-25
  • Contact: HUANG Wenjing

摘要: 乳糜泻是一种由麸质诱发的自身免疫性疾病,在我国存在认知度低、流行病学数据缺乏、漏诊率高的现状,在基层医疗卫生机构中缺乏相应的培训及诊疗路径。澳大利亚全科医生学会(RACGP)指南首次加入乳糜泻专题,并提出"不推荐普通人群筛查,但重视高危个体的病例发现"双重策略,为我国乳糜泻防控困境提供重要参考。参考国际指南的循证依据,强调对患有不明原因胃肠道症状、儿童生长迟缓、自身免疫性疾病等的个体进行针对性检查,血清学标志物抗组织转谷氨酰胺酶抗体敏感性高,十二指肠黏膜活检是"金标准",终身无麸质饮食可有效改善生活质量及长期预后。基于中国现状,在全科门诊建立高危人群识别与病例发现路径,提升中国全科医生对乳糜泻的警觉性和诊断能力,可改善患者生活质量及预后。

关键词: 乳糜泻, 筛查, 全科医生, 诊断, 无麸质饮食

Abstract:

Celiac disease is an autoimmune disorder triggered by gluten ingestion. In China, it remains underrecognized, with limited epidemiological data, a high rate of missed diagnosis, and a lack of standardized training and clinical pathways in primary care. The Royal Australian College of General Practitioners (RACGP) guidelines have recently incorporated a dedicated section on celiac disease, proposing a dual strategy that advises against general population screening while emphasizing active case-finding in high-risk individuals. This approach provides a relevant evidence-based reference for addressing diagnostic gaps in the Chinese context. Supported by international guidelines, targeted testing is recommended for individuals with unexplained gastrointestinal symptoms, impaired growth in children, or associated autoimmune conditions. Initial screening with the highly sensitive serological marker anti-tissue transglutaminase antibody is widely advised, followed by duodenal biopsy as the diagnostic gold standard. A lifelong strict gluten-free diet is effective in improving quality of life and long-term prognosis. In light of the current situation in China, implementing a structured pathway for risk-based identification and case-finding in general practice is of urgent practical importance. Enhancing awareness and diagnostic competency among Chinese general practitioners can facilitate earlier detection, improve patient outcomes, and strengthen primary care support for the systematic management of celiac disease.

Key words: Celiac disease, Mass screening, General practitioners, Diagnosis, Gluten-free diet