关键词: 肺疾病, 慢性阻塞性, 肺奴卡菌病, 诺卡尔菌感染, 临床特征, 影像特点, 诊断, 治疗, 预后

Abstract: Objective　To investigate the clinical and radiological characteristics of chronic obstructive pulmonary disease（COPD） complicated with pulmonary nocardiosis infection and its diagnosis and treatment and prognosis.Methods 　The clinical data of three patients with COPD complicated with pulmonary nocardiosis infection who were admitted to Zhejiang Quhua Hospital from March 2017 to September 2018 were analyzed and reported retrospectively and the literature were reviewed.Results　Cardinal symptoms of three patients included fever，cough，and coughing up yellow mucus.Computer tomography scan of chest showed nodules or masses，cavities，pleural effusion and consolidation.The most precise diagnosis method is mainly sputum culture.On the basis of Compound Sulphamethoxazole，the patients were treated with other antibiotics.All three patients were cured or in the improved condition.Conclusion　Structural pulmonary disease is the basis of pulmonary nocardia infection with non-specific clinical and radiological manifestations.The positive culture of nocardia pathogen is the mainly way of diagnosing the disease.Compound Sulphamethoxazole is the basic choice of treatment in combination with other drugs according to patient's condition.

Key words: Pulmonary disease, chronic obstructive；Pulmonary nocardia infection；Nocardia infections；Clinical characteristics；Radiological manifestations；Diagnosis；Therapy；Prognosis