中国全科医学 ›› 2020, Vol. 23 ›› Issue (19): 2472-2478.DOI: 10.12114/j.issn.1007-9572.2020.00.119
所属专题: 神经系统疾病最新文章合辑; 女性健康最新文章合辑; 脑健康最新研究合辑
• 专题研究 • 上一篇
白雪洁,周宏珍*,李牧玲,胡瑞丹,侯佳坤,刘杨杨
出版日期:
2020-07-05
发布日期:
2020-07-05
基金资助:
BAI Xuejie,ZHOU Hongzhen*,LI Muling,HU Ruidan,HOU Jiakun,LIU Yangyang
Published:
2020-07-05
Online:
2020-07-05
摘要: 脑卒中在其流行病学、危险因素等方面存在明显的性别差异,研究证实女性一生中经历的不可逆事件如妊娠、分娩等生殖因素会对女性终生的脑卒中发病风险产生较大影响,国外已对此进行了较全面的研究,并提出将对女性脑卒中风险的干预提前到妊娠期,相比较而言国内临床对此关注偏少。本研究综述了国内外关于女性生殖相关因素与脑卒中的研究,旨在完善医务人员对女性特有危险因素的病史采集,加强生殖相关因素的筛查、治疗及健康宣教,从而降低其终生脑卒中风险;同时或将弥补女性在此方面的防治知识空白,赋予女性及其家属更多的理解及应对自身风险的能力。
[1]王陇得,刘建民,彭斌,等.《中国脑卒中防治报告2017》概要[J].中国脑血管病杂志,2018,15(11):611-617.DOI:10.3969/j.issn.1672-5921.2018.11.010. [2]PETERS S A,WOODWARD M.Women's reproductive factors and incident cardiovascular disease in the UK Biobank[J].Heart,2018,104(13):1069-1075.DOI:10.1136/heartjnl-2017-312289. [3]SCOTT C A,BEWLEY S,RUDD A,et al.Incidence,risk factors,management,and outcomes of stroke in pregnancy[J].Obstet Gynecol,2013,33(1):318-324.DOI:10.1097/AOG.0b013e31825f287c. [4]BERENDS A L,DE GROOT C J,SIJBRANDS E J,et al.Shared constitutional risks for maternal vascular-related pregnancy complications and future cardiovascular disease[J].Hypertension,2008,51(4):1034-1041.DOI:10.1161/HYPERTENSIONAHA.107.101873. [5]MOSCA L,BENJAMIN E J,BERRA K,et al.Effectiveness-based guidelines for the prevention of cardiovascular disease in women:2011 update[J].Circulation,2011,123(11):1243-1262.DOI:10.1161/CIR.0b013e31820faaf8. [6]PIEPOLI M F,HOES A W,AGEWALL S,et al.2016 European guidelines on cardiovascular disease prevention in clinical practice:the sixth joint task force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice(constituted by representatives of 10 societies and by invited experts) developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation(EACPR)[J].Atherosclerosis,2016,23(11):1-96. [7]BUSHNELL C,MCCULLOUGH L D,AWAD I A,et al.Guidelines for the prevention of stroke in women:a statement for healthcare professionals from the american heart association American stroke association[J].Stroke,2014,45(5):1545-1588.DOI:10.1161/01.str.0000442009.06663.48. [8]CAROLAN M.Maternal age≥45 years and maternal and perinatal outcomes:a review of the evidence[J].Midwifery,2013,29(5):479-489.DOI:10.1016/j.midw.2012.04.001. [9]BIRO M A,DAVEY M A,CAROLAN M,et al.Advanced maternal age and obstetric morbidity for women giving birth in Victoria,Australia:apopulation-based study[J].Aust N Z J Obstet Gynaecol,2012,52(3):229-234.DOI:10.1111/j.1479-828X.2012.01427.x. [10]JAMES A H,BUSHNELL C D,JAMISON M G,et al.Incidence and risk factors for stroke in pregnancy and the puerperium[J].Obstet Gynecol,2005,106(3):509-516.DOI:10.1097/01.AOG.0000172428.78411.b0. [11]QURESHI A I,SAEED O,MALIK A A,et al.Pregnancy in advanced age and the risk of stroke in postmenopausal women:analysis of women's health initiative study[J].American Journal of Obstetrics and Gynecology,2017,216(4):401-409.DOI:10.1016/j.ajog.2016.12.004. [12]CHARACH R,WOLAK T,SHOHAM-VARDI I,et al.Can slight glucose intolerance during pregnancy predict future maternal atherosclerotic morbidity?[J].Diabetic Medicine,2016,33(7):920-925.DOI:10.1111/dme.13036. [13]JANET W R,ABIGAIL F,DEBORAH A L,et al.Pregnancy characteristics and women' s future cardiovascular health:an underused opportunity to improve women' s health?[J].Epidemiologic Reviews,2014,36(1):57-70.DOI:10.1093/epirev/mxt006. [14]RICH-EDWARDS J W.The predictive pregnancy what complicated pregnancies tell us about mother' s future cardiovascular risk[J].Circulation,2012,125(11):1336-1338.DOI:10.1161/CIRCULATIONAHA.112.093872. [15]LAO T T.The mother:the long-term implications on metabolic and cardiovascular complications[J].Best Practice & Research Clinical Obstetrics & Gynaecology,2015,29(2):244-255.DOI:10.1016/j.bpobgyn.2014.06.010. [16]CROVETTO F,SOMIGLIANA E,PEGUERO A,et al.Stroke during pregnancy and pre-eclampsia[J].Curr Opin Obstet Gynecol,2013,25(6):425-432.DOI:10.1097/GCO.0000000000000024. [17]MCDONALD S D,MALINOWSKI A,ZHOU Q,et al.Cardiovascular sequelae of preeclampsiaeclampsia:a systematic review and meta-analyses[J].Am Heart J,2008,156(5):918-930.DOI:10.1016/j.ahj.2008.06.042. [18]BROWN M C,BEST K E,PEARCE M S,et al.Cardiovascular disease risk in women with pre-eclampsia:systematic review and meta-analysis[J].European Journal of Epidemiology,2013,28(1):1-19.DOI:10.1007/s10654-013-9762-6. [19]LYKKE J A,LANGHOFF-ROOS J,SIBAI B M,et al.Hypertensive pregnancy disorders and subsequent cardiovascular morbidity and type 2 diabetes mellitus in the mother[J].Hypertension,2009,53(6):944-951.DOI:10.1161/HYPERTENSIONAHA.109.130765. [20]FRASER A,NELSON S M,MACDONALD-WALLIS C,et al.Associations of pregnancy complications with calculated cardiovascular disease risk and cardiovascular risk factors in middle age:the avon longitudinal study of parents and children[J].Circulation,2012,125(11):1367-1380.DOI:10.1161/CIRCULATIONAHA.111.044784. [21]METZGER B E,BUCHANAN T A,COUSTAN D R,et al.Summary and recommendations of the fifth international workshop-conference on gestational diabetes mellitus[J].Diabetes Care,2007,30(s2):251-260.DOI:10.2337/dc07-s225. [22]SONG C,LYU Y,LI C,et al.Long-term risk of diabetes in women at varying durations after gestational diabetes:a systematic review and meta-analysis with more than 2 million women[J].Obesity Reviews,2018,19(3):421-429.DOI:10.1111/obr.12645. [23]TOBIAS D K,HU F B,FORMAN J P,et al.Increased risk of hypertension after gestational diabetes mellitus:findings from a large prospective cohort study[J].Diabetes Care,2011,34(7):1582-1584.DOI:10.2337/dc11-0268. [24]GUNDERSON E P,CHIANG V,PLETCHER M J,et al.History of gestational diabetes mellitus and future risk of atherosclerosis in mid-life:the coronary artery risk development in young adults study[J].J Am Heart Assoc,2014,3(2):4901-4909.DOI:10.1161/JAHA.113.000490. [25]AJALA O,JENSEN L A,RYAN E,et al.Women with a history of gestational diabetes on long-term follow up have normal vascular function despite more dysglycemia,dyslipidemia and adiposity[J].Diabetes Res Clin Pract,2015,110(3):309-314.DOI:10.1016/j.diabres.2015.10.004. [26]LI J W,HE S Y,LIU P,et al.Association of gestational diabetes mellitus(GDM) with subclinical atherosclerosis:a systemic review and meta-analysis[J].BMC Cardiovasc Disord,2014,14(132):1-9.DOI:10.1186/1471-2261-14-132. [27]TOBIAS D K,STUART J J,LI S,et al.Association of history of gestational diabetes with long-term cardiovascular disease risk in a large prospective cohort of US women[J].JAMA Intern Med,2017,177(12):1735-1742.DOI:10.1001/jamainternmed.2017.2790. [28]SCOTT C A,BEWLEY S,RUDD A,et al.Incidence,risk factors,management,and outcomes of stroke in pregnancy[J].Obstet Gynecol,2012,120(1):318-324.DOI:10.1097/AOG.0b013e31825f287c. [29]GOUESLARD K,COTTENET J,MARIET A S,et al.Early cardiovascular events in women with a history of gestational diabetes mellitus[J].Cardiovasc Diabetol,2016,15(15):1-7.DOI:10.1186/s12933-016-0338-0. [30]RETNAKARAN R,SHAH B R.Glucose screening in pregnancy and future risk of cardiovascular disease in women:a retrospective,population-based cohort study[J].Lancet Diabetes Endocrinol,2019,7(5):378-384.DOI:10.1016/S2213-8587(19)30 077-4. [31]SEDGH G,BEARAK J,SINGH S,et al.Abortion incidence between 1990 and 2014:global,regional,and subregional levels and trends[J].Lancet,2016,388(10041):258-267.DOI:10.1016/S0140-6736(16)30380-4. [32]PETERS S A E,YANG L,GUO Y,et al.Pregnancy,pregnancy loss,and the risk of cardiovascular disease in Chinese women:findings from the China Kadoorie Biobank[J].BMC Medicine,2017,15(1):1-10.DOI:10.1186/s12916-017-0912-7. [33]KHARAZMI E,DOSSUS L,ROHRMANN S,et al.Pregnancy loss and risk of cardiovascular disease:a prospective population-based cohort study(EPIC-Heidelberg)[J].Heart,2010,97(1):49-54.DOI:10.1136/hrt.2010.202226. [34]MAINO A,SIEGERINK B,ALGRA A,et al.Pregnancy loss and risk of ischaemic stroke and myocardial infarction[J].Br J Haematol,2016,174(2):302-309.DOI:10.1111/bjh.14043. [35]RANTHE M F,ANDERSEN E A,WOHLFAHRT J,et al.Pregnancy loss and later risk of atherosclerotic disease[J].Circulation,2013,127(17):1775-1782.DOI:10.1161/CIRCULATIONAHA.112.000285. [36]MATTHIESEN L,KALKUNTE S,SHARMA S.Multiple pregnancy failures:an immunological paradigm[J].Am J Reprod Immunol,2012,67(4):334-340.DOI:10.1111/j.1600-0897.2012.01121.x. [37]SHETTY S,GHOSH K.Anti-phospholipid antibodies and other immunological causes of recurrent foetal loss:a review of literature of various therapeutic protocols[J].Am J Reprod Immunol,2009,62(1):9-24.DOI:10.1111/j.1600-0897.2009.00714.x. [38]GERMAIN A M,ROMANIK M C,GUERRA I,et al.Endothelial dysfunction:a link among preeclampsia,recurrent pregnancy loss,and future cardiovascular events?[J].Hypertension,2007,49(1):90-95.DOI:10.1161/01.HYP.0000251522.18094.d4. [39]SHEN L,WU J,XU G,et al.Parity and risk of coronary heart disease in middle-aged and older Chinese women.[J].Scientific Reports,2015,5(1):1-6.DOI:10.1038/srep16834. [40]QURESHI A I,GILES W H,CROFT J B,et al.Number of pregnancies and risk for stroke and stroke subtypes[J].Arch Neurol,1997,54(2):203-206.DOI:10.1001/archneur.1997.00550140073015. [41]ZHANG X,SHU X O,GAO Y T,et al.Pregnancy,childrearing,and risk of stroke in Chinese women[J].Stroke,2009,40(8):2680-2684.DOI:10.1161/STROKEAHA.109.547554. [42]ZHANG Y,SHEN L,WU J,et al.Parity and risk of stroke among chinese women:cross-sectional evidence from the dongfeng-tongji cohort study[J].Scientific Reports,2015,5(1):1-8.DOI:10.1038/srep16834. [43]WANG W P,CHEN F F,MI J,et al.Gestational weight gain and its relationship with the birthweight of offspring[J].Zhonghua Fu Chan Ke Za Zhi,2013,48(5):321-325. [44]WONG W,TANG N L,LAU T K,et al.A new recommendation for maternal weight gain in Chinese women[J].J Am Diet Assoc,2000,100(7):791-796.DOI:10.1016/S0002-8223(00)00230-3, [45]JUNTUNEN K,KIRKINEN P,KAUPPILA A.The clinical outcome in pregnancies of grand grand multiparous women[J].Acta Obstet Gynecol Scand,1997,76(8):755-759.DOI:10.3109/00016349709024342. [46]LAWLOR D A,EMBERSON J R,EBRAHIM S,et al.Is the association between parity and coronary heart disease due to biological effects of pregnancy or adverse lifestyle risk factors associated with child-rearing?Findings from the British women's heart and health study and the British regional heart study[J].Circulation,2003,107(9):1260-1264.DOI:10.1161/01.cir.0000053441.43495.1a. [47]UNAR-MUNGUIA M,TORRES-MEJIA G,COLCHERO M A,et al.Breastfeeding mode and risk of breast cancer:a dose-response meta-analysis[J].J Hum Lact,2017,33(2):422-434.DOI:10.1177/0890334416683676. [48]JORDAN S J,CUSHING-HAUGEN K L,WICKLUND K G,et al.Breast-feeding and risk of epithelial ovarian cancer[J].Cancer Causes Control,2012,23(6):919-927.DOI:10.1007/s10552-012-9963-4. [49]GALLAGHER L G,DAVIS L B,RAY R M,et al.Reproductive history and mortality from cardiovascular disease among women textile workers in Shanghai,China[J].Int J Epidemiol,2011,40(6):1510-1518.DOI:10.1093/ije/dyr134. [50]JACOBSON L T,HADE E M,COLLINS T C,et al.Breastfeeding history and risk of stroke among parous postmenopausal women in the women's health initiative[J].J Am Heart Assoc,2018,7(17):1-11.DOI:10.1161/JAHA.118.008739. [51]SCHWARZ E B,RAY R M,STUEBE A M,et al.Duration of lactation and risk factors for maternal cardiovascular disease[J].Obstet Gynecol,2009,113(5):974-982.DOI:10.1097/01.AOG.0000346884.67796.ca. [52]KIRKEGAARD H,STOVRING H,RASMUSSEN K M,et al.How do pregnancy-related weight changes and breastfeeding relate to maternal weight and BMI-adjusted waist circumference 7 y after delivery? Results from a path analysis[J].Am J Clin Nutr,2014,99(2):312-319.DOI:10.3945/ajcn.113.067405. [53]MCCLURE C K,CATOV J M,NESS R B,et al.Lactation and maternal subclinical cardiovascular disease among premenopausal women[J].Am J Obstet Gynecol,2012,207(1):41-46.DOI:10.1016/j.ajog.2012.04.030. [54]MENDELSOHN M E,KARAS R H.The protective effects of estrogen on the cardiovascular system[J].N Engl J Med,1999,340(23):1801-1811.DOI:10.1056/NEJM199906103402306. [55]ELKS C E,ONG K K,SCOTT R A,et al.Age at menarche and type 2 diabetes risk:the EPIC-InterAct study[J].Diabetes Care,2013,36(11):3526-3534.DOI:10.2337/dc13-0446. [56]CHARALAMPOPOULOS D,MCLOUGHLIN A,ELKS C E,et al.Age at menarche and risks of all-cause and cardiovascular death:a systematic review and meta-analysis[J].American Journal of Epidemiology,2014,180(1):29-40.DOI:10.1093/aje/kwu113. [57]DAY F R,ELKS C E,MURRAY A,et al.Puberty timing associated with diabetes,cardiovascular disease and also diverse health outcomes in men and women:the UK Biobank study[J].Scientific Reports,2015,5(1):1-12.DOI:10.1038/srep11208. [58]JACOBSEN B K,ODA K,KNUTSEN S F,et al.Age at menarche,total mortality and mortality from ischaemic heart disease and stroke:the adventist health study,1976-1988[J].International Journal of Epidemiology,2009,38(1):245-252.DOI:10.1093/ije/dyn251. [59]CANOY D,BERAL V,BALKWILL A,et al.Age at menarche and risks of coronary heart and other vascular diseases in a large UK cohort[J].Circulation,2015,131(3):237-244.DOI:10.1161/CIRCULATIONAHA.114.010070. [60]YANG L,LI L,MILLWOOD I Y,et al.Age at menarche and risk of major cardiovascular diseases:evidence of birth cohort effects from a prospective study of 300 000 Chinese women[J].International Journal of Cardiology,2017,227:497-502.DOI:10.1016/j.ijcard.2016.10.115. [61]WU X,CAI H,KALLIANPUR A,et al.Age at menarche and natural menopause and number of reproductive years in association with mortality:results from a median follow-up of 11.2 years among 31 955 naturally menopausal Chinese women[J].PLoS One,2014,9(8):1-10.DOI:10.1371/journal.pone.0103673. [62]PRENTICE P,VINER R M.Pubertal timing and adult obesity and cardiometabolic risk in women and men:a systematic review and meta-analysis[J].Int J Obes(Lond),2013,37(8):1036-1043.DOI:10.1038/ijo.2012.177. [63]LISABETH L,BUSHNELL C.Stroke risk in women:the role of menopause and hormone therapy[J].The Lancet Neurology,2012,11(1):82-91.DOI:10.1016/S1474-4422(11)70 269-1. [64]MATTHEWS K A,KULLER L H,SUTTON-TYRRELL K, et al.Changes in cardiovascular risk factors during the perimenopause and postmenopause and carotid artery atherosclerosis in healthy women[J].Stroke,2001,32(5):1104-1111.DOI:10.1161/01.str.32.5.1104. [65]YANG L,LIN L,KARTSONAKI C,et al.Menopause characteristics,total reproductive years,and risk of cardiovascular disease among chinese women[J].Circulation:Cardiovascular Quality and Outcomes,2017,10(11):1-9.DOI:10.1161/CIRCOUTCOMES.117.004235. [66]MUKA T,OLIVER-WILLIAMS C,KUNUTSOR S,et al.Association of age at onset of menopause and time since onset of menopause with cardiovascular outcomes,intermediate vascular traits,and all-cause mortality:a systematic review and meta-analysis[J].JAMA Cardiol,2016,1(7):767-776.DOI:10.1001/jamacardio.2016.2415. [67]ZHU D,CHUNG H F,PANDEYA N,et al.Premenopausal cardiovascular disease and age at natural menopause:a pooled analysis of over 170 000 women[J].Eur J Epidemiol,2019,34(3):235-246.DOI:10.1007/s10654-019-00490-w. [68]HU F B,GRODSTEIN F,HENNEKENS C H,et al.Age at natural menopause and risk of cardiovascular disease[J].Arch Intern Med,1999,159(10):1061-1066.DOI:10.1001/archinte.159.10.1061. [69]BABA Y,ISHIKAWA S,AMAGI Y,et al.Premature menopause is associated with increased risk of cerebral infarction in Japanese women[J].Menopause,2010,17(3):506-510.DOI:10.1097/gme.0b013e3181c7dd41. [70]INGELSSON E,LUNDHOLM C,JOHANSSON A L,et al.Hysterectomy and risk of cardiovascular disease:a population-based cohort study[J].Eur Heart J,2011,32(6):745-750.DOI:10.1093/eurheartj/ehq477. [71]PARKER W H,BRODER M S,CHANG E,et al.Ovarian conservation at the time of hysterectomy and long-term health outcomes in the nurses' health study[J].Obstet Gynecol,2009,113(5):1027-1037.DOI:10.1097/AOG.0b013e3181a11c64. [72]VESSEY M P,DOLL R.Investigation of relation between use of oral contraceptives and thromboembolic disease.A further report[J].Br Med J,1969,2(5658):651-657.DOI:10.1136/bmj.2.5658.651. [73]POULTER N R,CHANG C L,FARLEY T M M,et al.Ischaemic stroke and combined oral contraceptives:results of an international,multicentre,case-control study WHO collaborative study of cardiovascular disease and steroid hormone contraception[J].Lancet,1996,348(9026):498-505. [74]GILLUM L A,MAMIDIPUDI S K,JOHNSTON S C.Ischemic stroke risk with oral contraceptives:a meta-analysis[J].JAMA,2000,284(1):72-78.DOI:10.1001/jama.284.1.72. [75]POULTER N R,CHANG C L,FARLEY T M M,et al.Haemorrhagic stroke,overall stroke risk,and combined oral contraceptives:results of an international,multicentre,case-control study.[J].The Lancet,1996,348(9026):505-510. [76]WANG C,LI Y,LI H,et al.Increased risk of stroke in oral contraceptive users carried replicated genetic variants:a population-based case-control study in China[J].Human Genetics,2012,131(8):1337-1344.DOI:10.1007/s00439-012-1161-1167. [77]LI Y,ZHOU L,COULTER D,et al.Prospective cohort study of the association between use of low-dose oral contraceptives and stroke in Chinese women[J].Pharmacoepidemiology and Drug Safety,2006,15(10):726-734.DOI:10.1002/pds.1266. [78]TEPPER N K,WHITEMAN M K,ZAPATA L B,et al.Safety of hormonal contraceptives among women with migraine:a systematic review[J].Contraception,2016,94(6):630-640.DOI:10.1016/j.contraception.2016.04.016. [79]PERAGALLO U R,COEYTAUX R R,MCBROOM A J,et al. Risk of acute thromboembolic events with oral contraceptive use:a systematic review and meta-analysis[J].Obstet Gynecol,2013,122(1):380-389.DOI:10.1097/AOG.0b013e3182994c43. [80]BASSUK S S,MANSON J E.Oral contraceptives and menopausal hormone therapy:relative and attributable risks of cardiovascular disease,cancer,and other health outcomes[J].Ann Epidemiol,2015,25(3):193-200.DOI:10.1016/j.annepidem.2014.11.004. [81]STAMPFER M J,WILLETT W C,COLDITZ G A,et al.Past use of oral contraceptives and cardiovascular disease:a meta-analysis in the context of the nurses' health study[J].Am J Obstet Gynecol,1990,163(1):285-291.DOI:10.1016/0002-9378(90)90569-s. [82]STAMPFER M J,COLDITZ G A.Estrogen replacement therapy and coronary heart disease:a quantitative assessment of the epidemiologic evidence[J].Prev Med,1991,20(1):47-63.DOI:10.1016/0091-7435(91)90006-p. [83]FERRUCCI L,BENVENUTI E,BARTALI B,et al.Preventive health care for older women:life-style recommendations and new directions[J].Aging(Milano),2000,12(2):113-131. [84]NELSON H D,HUMPHREY L L,NYGREN P,et al.Postmenopausal hormone replacement therapy:scientific review[J].JAMA,2002,288(7):872-881.DOI:10.1001/jama.288.7.872. [85]PAGANINIHILL A.Hormone replacement therapy and stroke:risk,protection or no effect?[J].Maturitas,2001,38(3):243-261.DOI:10.1016/s0378-5122(01)00167-0. [86]SIMON J A,HSIA J,CAULEY J A,et al.Postmenopausal hormone therapy and risk of stroke:the heart and estrogen-progestin replacement study(HERS)[J].Circulation,2001,103(5):638-642. [87]STEERING T W H I.Effects of conjugated equine estrogen in postmenopausal women with hysterectomythe women's health initiative randomized controlled trial[J].JAMA,2004,291(14):1701-1712.DOI:10.1001/jama.291.14.1701. [88]GROSSMAN D C,CURRY S J,OWENS D K,et al.Hormone therapy for the primary prevention of chronic conditions in postmenopausal women[J].JAMA,2017,318(22):2224-2233.DOI:10.1001/jama.2017.18261. |
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