经血源性干细胞联合补肾活血类中药治疗子宫内膜功能减退类疾病的研究进展

doi:10.12114/j.issn.1007-9572.2024.0413

中国全科医学 ›› 2026, Vol. 29 ›› Issue (11): 1481-1487.DOI: 10.12114/j.issn.1007-9572.2024.0413

所属专题：女性健康最新文章合辑

经血源性干细胞联合补肾活血类中药治疗子宫内膜功能减退类疾病的研究进展

孙宇辰¹, 石雅馨¹, 师伟²^,^*()

1．250014　山东省济南市，山东中医药大学第一临床医学院
2．250014　山东省济南市，山东中医药大学附属医院妇科

收稿日期:2024-06-13 修回日期:2024-11-02 出版日期:2026-04-15 发布日期:2026-03-12
通讯作者: 师伟
作者贡献：
孙宇辰负责拟定写作思路及撰写论文；石雅馨负责收集资料以及修改论文；师伟负责指导撰写论文并最后定稿。
基金资助:
山东省自然科学基金创新发展联合基金项目(ZR202306250028); 泰山学者青年专家(NO.tsqn201909185); 山东省自然科学基金面上项目(ZR2021MH198); 山东省中医药科技面上项目(M-2023259)

Advancements in the Treatment of Endometrial Hypofunction Diseases Using Menstrual Blood-derived Endometrium Stem Cells Combined with Traditional Chinese Medicine for Tonifying Kidney and Activating Blood in Regenerative Medicine

SUN Yuchen¹, SHI Yaxin¹, SHI Wei²^,^*()

1. The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
2. Gynecology Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China

Received:2024-06-13 Revised:2024-11-02 Published:2026-04-15 Online:2026-03-12
Contact: SHI Wei

摘要/Abstract

摘要： 在传统治疗策略对子宫内膜功能减退类疾病治疗效果受限的环境下，细胞疗法尤其是干细胞技术在创新性与疗效上展示着显著潜力。本综述深入讨论了经血源性干细胞（MenSCs）的研究进展以及其与补肾活血类中药联合治疗的成果与前景，从方药和MenSCs角度探讨二者治疗子宫内膜功能减退类疾病的机制，进而对MenSCs与补肾活血类中药在创新性领域应用治疗该病症进行可行性探讨。本文旨在通过综述干细胞疗法的疗效，以推动再生医学与中医药学、材料学的深度融合，从而开辟更为全面且个性化的治疗新策略。

关键词: 子宫内膜功能减退类疾病, 经血源性干细胞, 补肾活血类中药, 综述

Abstract:

In an environment where conventional therapeutic methods have limited effectiveness in treating endometrial hypoplasia, cellular therapies, especially stem cell technology, have demonstrated significant potential for innovation and efficacy. This review explored the advancements in menstrual stem cell (MenSC) research and examined the outcomes and future prospects of combining MenSCs with Chinese medicine for tonifying kidney and activating blood. We investigated the mechanisms of endometrial hypoplasia from the perspectives of pharmacological prescriptions and MenSCs, and subsequently discussed the potential of MenSCs, along with Chinese medicine for tonifying kidney and activating blood, within the innovative field of treating this condition. The purpose of this review was to promote the deep integration of regenerative medicine with Chinese medicine and materials science through summarizing the effectiveness of stem cell therapy, thereby revealing new strategies for more comprehensive and personalized treatment approaches.

Key words: Endometrial dysfunction, Menstrual blood-derived stem cells, Traditional Chinese medicine for tonifying kidney and activating blood, Review

中图分类号:

R 711.74

孙宇辰,石雅馨,师伟. 经血源性干细胞联合补肾活血类中药治疗子宫内膜功能减退类疾病的研究进展[J]. 中国全科医学, 2026, 29(11): 1481-1487. DOI: 10.12114/j.issn.1007-9572.2024.0413.
SUN Yuchen,SHI Yaxin,SHI Wei. Advancements in the Treatment of Endometrial Hypofunction Diseases Using Menstrual Blood-derived Endometrium Stem Cells Combined with Traditional Chinese Medicine for Tonifying Kidney and Activating Blood in Regenerative Medicine[J]. Chinese General Practice, 2026, 29(11): 1481-1487. DOI: 10.12114/j.issn.1007-9572.2024.0413.

图/表 1

参考文献 73

[1]	师伟，张芳，李盼盼, 等. 子宫内膜病变的疾病分类特征和"异病同治"共性发病机制的思考[J]. 世界科学技术-中医药现代化, 2020, 22(12): 4345-4351. DOI: 10.11842/wst.20200307009.
[2]	石雅馨，师伟，葛晓晨, 等. 基于"异病同治"刍议子宫内膜功能减退类疾病[J]. 辽宁中医药大学学报, 2020, 22(11): 150-153. DOI: 10.13194/j.issn.1673-842x.2020.11.035.
[3]	王艺绚，庞聪慧，吴海萃, 等. 中药联合腔内理疗治疗薄型子宫内膜经验撷菁[J]. 中华中医药杂志, 2024, 39(2): 784-787.
[4]	KASIUS A, SMIT J G, TORRANCE H L, et al. Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis[J]. Hum Reprod Update, 2014, 20(4): 530-541. DOI: 10.1093/humupd/dmu011.
[5]	GHARIBEH N, AGHEBATI-MALEKI L, MADANI J, et al. Cell-based therapy in thin endometrium and Asherman syndrome[J]. Stem Cell Res Ther, 2022, 13(1): 33. DOI: 10.1186/s13287-021-02698-8.
[6]	LV H N, ZHAO G F, JIANG P P, et al. Deciphering the endometrial niche of human thin endometrium at single-cell resolution[J]. Proc Natl Acad Sci USA, 2022, 119(8): e2115912119. DOI: 10.1073/pnas.2115912119.
[7]	MIWA I, TAMURA H, TAKASAKI A, et al. Pathophysiologic features of "thin" endometrium[J]. Fertil Steril, 2009, 91(4): 998-1004. DOI: 10.1016/j.fertnstert.2008.01.029.
[8]	TAKASAKI A, TAMURA H, MIWA I, et al. Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium[J]. Fertil Steril, 2010, 93(6): 1851-1858. DOI: 10.1016/j.fertnstert.2008.12.062.
[9]	SALAZAR C A, ISAACSON K, MORRIS S. A comprehensive review of asherman's syndrome: causes, symptoms and treatment options[J]. Curr Opin Obstet Gynecol, 2017, 29(4): 249-256. DOI: 10.1097/GCO.0000000000000378.
[10]	LI J, PAN Y, YANG J, et al. Tumor necrosis factor-α-primed mesenchymal stem cell-derived exosomes promote M2 macrophage polarization via Galectin-1 and modify intrauterine adhesion on a novel murine model[J]. Front Immunol, 2022, 13: 945234. DOI: 10.3389/fimmu.2022.945234.
[11]	WANG Y, TANG Z, TENG X. New advances in the treatment of thin endometrium[J]. Front Endocrinol(Lausanne), 2024, 15: 1269382. DOI: 10.3389/fendo.2024.1269382.
[12]	YANG X, LIU Y H, LI T C, et al. Durations of intrauterine balloon therapy and adhesion reformation after hysteroscopic adhesiolysis: a randomized controlled trial[J]. Reprod Biomed Online, 2020, 40(4): 539-546. DOI: 10.1016/j.rbmo.2019.11.017.
[13]	DEANS R, ABBOTT J. Review of intrauterine adhesions[J]. J Minim Invasive Gynecol, 2010, 17(5): 555-569. DOI: 10.1016/j.jmig.2010.04.016.
[14]	YU D, WONG Y M, CHEONG Y, et al. Asherman syndrome—one century later[J]. Fertil Steril, 2008, 89(4): 759-779. DOI: 10.1016/j.fertnstert.2008.02.096.
[15]	MCCOMB P F, WAGNER B L. Simplified therapy for asherman's syndrome[J]. Fertil Steril, 1997, 68(6): 1047-1050. DOI: 10.1016/s0015-0282(97)00413-5.
[16]	DARZI S, ZARNANI A H, JEDDI-TEHRANI M, et al. Osteogenic differentiation of stem cells derived from menstrual blood versus bone marrow in the presence of human platelet releasate[J]. Tissue Eng Part A, 2012, 18(15/16): 1720-1728. DOI: 10.1089/ten.TEA.2011.0386.
[17]	BUZHOR E, LESHANSKY L, BLUMENTHAL J, et al. Cell-based therapy approaches: the hope for incurable diseases[J]. Regen Med, 2014, 9(5): 649-672. DOI: 10.2217/rme.14.35.
[18]	BACAKOVA L, ZARUBOVA J, TRAVNICKOVA M, et al. Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells-a review[J]. Biotechnol Adv, 2018, 36(4): 1111-1126. DOI: 10.1016/j.biotechadv.2018.03.011.
[19]	KESHTKAR S, AZARPIRA N, GHAHREMANI M H. Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine[J]. Stem Cell Res Ther, 2018, 9(1): 63. DOI: 10.1186/s13287-018-0791-7.
[20]	LE BLANC K, MOUGIAKAKOS D. Multipotent mesenchymal stromal cells and the innate immune system[J]. Nat Rev Immunol, 2012, 12(5): 383-396. DOI: 10.1038/nri3209.
[21]	HAYNESWORTH S E, BABER M A, CAPLAN A I. Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1 alpha[J]. J Cell Physiol, 1996, 166(3): 585-592. DOI: 10.1002/(SICI)1097-4652(199603)166:3585:AID-JCP13>3.0.CO;2-6.
[22]	KHOURY M, ALCAYAGA-MIRANDA F, ILLANES S E, et al. The promising potential of menstrual stem cells for antenatal diagnosis and cell therapy[J]. Front Immunol, 2014, 5: 205. DOI: 10.3389/fimmu.2014.00205.
[23]	LIN J, XIANG D, ZHANG J L, et al. Plasticity of human menstrual blood stem cells derived from the endometrium[J]. J Zhejiang Univ Sci B, 2011, 12(5): 372-380. DOI: 10.1631/jzus.B1100015.
[24]	PERON J P S, JAZEDJE T, BRANDÃO W N, et al. Human endometrial-derived mesenchymal stem cells suppress inflammation in the central nervous system of EAE mice[J]. Stem Cell Rev Rep, 2012, 8(3): 940-952. DOI: 10.1007/s12015-011-9338-3.
[25]	PREVOSTO C, ZANCOLLI M, CANEVALI P, et al. Generation of CD₄⁺ or CD₈⁺ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction[J]. Haematologica, 2007, 92(7): 881-888. DOI: 10.3324/haematol.11240.
[26]	RUSSELL M W, MESTECKY J. Tolerance and protection against infection in the genital tract[J]. Immunol Invest, 2010, 39(4/5): 500-525. DOI: 10.3109/08820131003674834.
[27]	MENG X L, ICHIM T E, ZHONG J, et al. Endometrial regenerative cells: a novel stem cell population[J]. J Transl Med, 2007, 5(1): 57. DOI: 10.1186/1479-5876-5-57.
[28]	LUZ-CRAWFORD P, TORRES M J, NOËL D, et al. The immunosuppressive signature of menstrual blood mesenchymal stem cells entails opposite effects on experimental arthritis and graft versus host diseases[J]. Stem Cells, 2016, 34(2): 456-469. DOI: 10.1002/stem.2244.
[29]	蒲丽萍，叶秀英，付译漫, 等. 叶秀英运用通补二法辨治薄型子宫内膜经验[J]. 中医学报, 2024, 39(5): 1024-1028. DOI: 10.16368/j.issn.1674-8999.2024.05.174.
[30]	耿丹丹，魏绍斌. 宫腔粘连的中医药治疗方法[J]. 实用妇产科杂志, 2024, 40(4): 251-254.
[31]	李颢玥，王茜，郝蕾. 补肾活血方对肾虚血瘀型子宫内膜增生症大鼠的作用及机制研究[J]. 中药新药与临床药理, 2024, 35(5): 623-632. DOI: 10.19378/j.issn.1003-9783.2024.05.003.
[32]	贺艳，张乐乐，陈旭佳, 等. 菟丝子-桑寄生改善小鼠卵巢储备功能及子宫内膜容受性[J]. 中药与临床, 2022, 13(5): 48-51.
[33]	董冰峰，方肇勤，施建蓉, 等. 二仙汤及其拆方对大鼠卵泡颗粒细胞分泌功能的影响[J]. 中国中西医结合杂志, 2006, 26(S1): 122-125.
[34]	李彩云，肖青，李鑫辉, 等. 丹参通络解毒汤联合内皮祖细胞移植对心肌缺血再灌注损伤大鼠促血管新生作用的研究[J]. 中华中医药学刊, 2022, 40(1): 25-29, 260-262. DOI: 10.13193/j.issn.1673-7717.2022.01.007.
[35]	戴酉力，邓曦东，牛伯晖, 等. 三七总皂苷复合纳米囊泡对糖尿病足溃疡大鼠皮肤创面愈合及血管生成的影响[J]. 广西医科大学学报, 2024, 41(1): 51-57. DOI: 10.16190/j.cnki.45-1211/r.2024.01.008.
[36]	祁琳，韩鑫羽，祁璐, 等. 红景天苷对血管生成及骨血管偶联的影响[J]. 武警医学, 2024, 35(1): 1-5. DOI: 10.14010/j.cnki.wjyx.2024.01.002.
[37]	郭琰，杨庆，李琦, 等. 全三七片对血管内皮细胞损伤的保护作用研究[J]. 中国中医基础医学杂志, 2023, 29(8): 1352-1357. DOI: 10.19945/j.cnki.issn.1006-3250.2023.08.009.
[38]	李姣，林洁，易星星, 等. 基于TGF-β1/Smad通路探究补肾化瘀方对宫腔粘连大鼠子宫内膜纤维化的作用及机制[J]. 中医药导报, 2021, 27(11): 7-11, 17. DOI: 10.13862/j.cnki.cn43-1446/r.2021.11.002.
[39]	QIU S J, SUN G L, ZHANG Y X, et al. Involvement of the NF-κB signaling pathway in the renoprotective effects of isorhamnetin in a type 2 diabetic rat model[J]. Biomed Rep, 2016, 4(5): 628-634. DOI: 10.3892/br.2016.636.
[40]	朴金花，欧芹，王昭, 等. 生菟丝子、盐制菟丝子对D-半乳糖所致衰老模型小鼠免疫功能影响[J]. 中国老年学杂志, 2005, 25(4): 452-453. DOI: 10.3969/j.issn.1005-9202.2005.04.046.
[41]	郭红艳，张鹏霞，欧芹, 等. 山茱萸对衰老大鼠蛋白质非酶糖化及DNA损伤的影响[J]. 中国临床康复, 2005, 9(19): 136-137. DOI: 10.3321/j.issn:1673-8225.2005.19.072.
[42]	CHOI Y H. Schisandrin A prevents oxidative stress-induced DNA damage and apoptosis by attenuating ROS generation in C2C12 cells[J]. Biomed Pharmacother, 2018, 106: 902-909. DOI: 10.1016/j.biopha.2018.07.035.
[43]	FENG J H, LIAO L, XU F F, et al. Combination of stem cells with Chinese herbs for secondary depression in neurodegenerative diseases based on traditional Chinese medicine theories[J]. Evid Based Complement Alternat Med, 2022, 2022: 6847917. DOI: 10.1155/2022/6847917.
[44]	YAMCHI N N, RAHBARGHAZI R, BEDATE A M, et al. Menstrual blood CD146⁺ mesenchymal stem cells reduced fibrosis rate in the rat model of premature ovarian failure[J]. Cell Biochem Funct, 2021, 39(8): 998-1008. DOI: 10.1002/cbf.3669.
[45]	ZAFARDOUST S, KAZEMNEJAD S, FATHI-KAZEROONI M, et al. The effects of intraovarian injection of autologous menstrual blood-derived mesenchymal stromal cells on pregnancy outcomes in women with poor ovarian response[J]. Stem Cell Res Ther, 2023, 14(1): 332. DOI: 10.1186/s13287-023-03568-1.
[46]	WANG Z, WANG Y L, YANG T, et al. Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice[J]. Stem Cell Res Ther, 2017, 8(1): 11. DOI: 10.1186/s13287-016-0458-1.
[47]	SHIBUYA M. Vascular endothelial growth factor(VEGF)and its receptor(VEGFR)signaling in angiogenesis: a crucial target for anti- and pro-angiogenic therapies[J]. Genes Cancer, 2011, 2(12): 1097-1105. DOI: 10.1177/1947601911423031.
[48]	SENGER D R, CLAFFEY K P, BENES J E, et al. Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins[J]. Proc Natl Acad Sci USA, 1997, 94(25): 13612-13617. DOI: 10.1073/pnas.94.25.13612.
[49]	CHEN L J, QU J J, CHENG T L, et al. Menstrual blood-derived stem cells: toward therapeutic mechanisms, novel strategies, and future perspectives in the treatment of diseases[J]. Stem Cell Res Ther, 2019, 10(1): 406. DOI: 10.1186/s13287-019-1503-7.
[50]	ZHANG X D, ZHANG S W, QI J R, et al. PDGFBB improved the biological function of menstrual blood-derived stromal cells and the anti-fibrotic properties of exosomes[J]. Stem Cell Res Ther, 2023, 14(1): 113. DOI: 10.1186/s13287-023-03339-y.
[51]	DE PEDRO M Á, GÓMEZ-SERRANO M, MARINARO F, et al. IFN-gamma and TNF-alpha as a priming strategy to enhance the immunomodulatory capacity of secretomes from menstrual blood-derived stromal cells[J]. Int J Mol Sci, 2021, 22(22): 12177. DOI: 10.3390/ijms222212177.
[52]	XU H, FU J, CHEN L, et al. TNF-α enhances the therapeutic effects of MenSC-derived small extracellular vesicles on inflammatory bowel disease through macrophage polarization by miR-24-3p[J]. Stem Cells Int, 2023: 2988907. DOI: 10.1155/2023/2988907.
[53]	王南丁，李哲，张晓萍, 等. 中医药参与干细胞研究特色及进展[J]. 现代生物医学进展, 2013, 13(36): 7157-7159, 7185. DOI: 10.13241/j.cnki.pmb.2013.36.010.
[54]	钱晓伟，潘丹岷，谭湘陵, 等. 中药血清对大鼠bMSCs体外成软骨分化中Col2a1和Acan表达的影响[J]. 时珍国医国药, 2012, 23(2): 340-343. DOI: 10.3969/j.issn.1008-0805.2012.02.039.
[55]	MA H L, LIU M T, LI Y F, et al. Intrauterine transplantation of autologous menstrual blood stem cells increases endometrial thickness and pregnancy potential in patients with refractory intrauterine adhesion[J]. J Obstet Gynaecol Res, 2020, 46(11): 2347-2355. DOI: 10.1111/jog.14449.
[56]	SUN Y L, REN Y K, YANG F, et al. High-yield isolation of menstrual blood-derived endometrial stem cells by direct red blood cell lysis treatment[J]. Biol Open, 2019, 8(5): bio038885. DOI: 10.1242/bio.038885.
[57]	HO A, NAKATSUJI N. Editorial: "crossing boundaries: stem cells, materials, and mesoscopic sciences"[J]. Biotechnol J, 2012, 7(6): 694-695. DOI: 10.1002/biot.201200156.
[58]	PANWAR A, TAN L P. Current status of bioinks for micro-extrusion-based 3D bioprinting[J]. Molecules, 2016, 21(6): 685. DOI: 10.3390/molecules21060685.
[59]	MATAI I, KAUR G, SEYEDSALEHI A, et al. Progress in 3D bioprinting technology for tissue/organ regenerative engineering[J]. Biomaterials, 2020, 226: 119536. DOI: 10.1016/j.biomaterials.2019.119536.
[60]	WANG L J, YU C H, CHANG T L, et al. In situ repair abilities of human umbilical cord-derived mesenchymal stem cells and autocrosslinked hyaluronic acid gel complex in Rhesus monkeys with intrauterine adhesion[J]. Sci Adv, 2020, 6(21): eaba6357. DOI: 10.1126/sciadv.aba6357.
[61]	CHEN T X, YANG Y, PENG H, et al. Cellulose nanocrystals reinforced highly stretchable thermal-sensitive hydrogel with ultra-high drug loading[J]. Carbohydr Polym, 2021, 266: 118122. DOI: 10.1016/j.carbpol.2021.118122.
[62]	NIE N F, GONG L, JIANG D M, et al. 3D bio-printed endometrial construct restores the full-thickness morphology and fertility of injured uterine endometrium[J]. Acta Biomater, 2023, 157: 187-199. DOI: 10.1016/j.actbio.2022.12.016.
[63]	高华. 经血源性间充质干细胞与温敏性水凝胶构建细胞支架复合物的体外研究[D]. 郑州: 郑州大学, 2022.
[64]	LI Z H, ZHAO Y L, OUYANG X X, et al. Biomimetic hybrid hydrogel for hemostasis, adhesion prevention and promoting regeneration after partial liver resection[J]. Bioact Mater, 2022, 11: 41-51. DOI: 10.1016/j.bioactmat.2021.10.001.
[65]	HE W, ZHANG X, LI X, et al. A decellularized spinal cord extracellular matrix-gel/GelMA hydrogel three-dimensional composite scaffold promotes recovery from spinal cord injury via synergism with human menstrual blood-derived stem cells[J]. J Mater Chem B, 2022, 10(30): 5753-5764. DOI: 10.1039/d2tb00792d
[66]	WU M, WU S, TAN S, et al. VitroGel-loaded human MenSCs promote endometrial regeneration and fertility restoration[J]. Front Bioeng Biotechnol, 2024, 11: 1310149. DOI: 10.3389/fbioe.2023.131014.
[67]	HAO X Y, ZHANG S W, LI P P, et al. Amniotic membrane extract-enriched hydrogel augments the therapeutic effect of menstrual blood-derived stromal cells in a rat model of intrauterine adhesion[J]. Biomater Adv, 2022, 142: 213165. DOI: 10.1016/j.bioadv.2022.213165.
[68]	李清音，李林华，张春乐, 等. 内皮祖细胞与间充质干细胞治疗血管支架相关疾病[J]. 中国组织工程研究, 2025, 29(19): 4091-4101.
[69]	MERDAN T, KOPECEK J, KISSEL T. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer[J]. Adv Drug Deliv Rev, 2002, 54(5): 715-758. DOI: 10.1016/s0169-409x(02)00046-7.
[70]	韩静，包纯洁，段嘉伦. 中药活性成分作为药物递送纳米载体的研究进展[J]. 中草药, 2024, 55(16): 5678-5691.
[71]	张建武. 葛根素水凝胶在MSCs移植治疗心肌梗死中的作用及机制研究[D]. 广州: 南方医科大学, 2016.
[72]	韩朝. 丝素蛋白水凝胶结合NSC对缺血缺氧脑损伤的修复及姜黄素的干预作用研究[D]. 大连: 大连医科大学, 2020.
[73]	吕妍. 归肾丸联合水凝胶-干细胞复合物治疗子宫内膜损伤的研究[D]. 广州: 广州中医药大学, 2022.

材料	特点	应用	参考文献
氧化透明质酸、乙二醇壳聚糖（GC）和MenSCs	通过动态席夫碱连接实现了快速原位形成，并具有自愈合能力	肝切除术后肝细胞的增殖和组织再生	[64]
DSCG与GelMA水凝胶混合并搭载MenSCs	减轻炎症，还可以促进轴突再生和神经元发育，抑制胶质瘢痕形成	减轻脊髓损伤创面炎症反应，促进神经元分化	[65]
VitroGel MMP水凝胶系统与MenSCs	增强生物相容性和可生物降解性，为细胞生长提供优化的环境，支持各种生物活性	子宫内膜容受性降低导致的生育功能障碍	[66]
富含羊膜提取物精氨酰-甘氨酰-天冬氨酸水凝胶联合MenSCs	富含多种生长因子和细胞因子，抗炎和伤口愈合能力出色	子宫内膜再生，减少纤维化，提高生育能力	[67]

材料	特点	应用	参考文献
氧化透明质酸、乙二醇壳聚糖（GC）和MenSCs	通过动态席夫碱连接实现了快速原位形成，并具有自愈合能力	肝切除术后肝细胞的增殖和组织再生	[64]
DSCG与GelMA水凝胶混合并搭载MenSCs	减轻炎症，还可以促进轴突再生和神经元发育，抑制胶质瘢痕形成	减轻脊髓损伤创面炎症反应，促进神经元分化	[65]
VitroGel MMP水凝胶系统与MenSCs	增强生物相容性和可生物降解性，为细胞生长提供优化的环境，支持各种生物活性	子宫内膜容受性降低导致的生育功能障碍	[66]
富含羊膜提取物精氨酰-甘氨酰-天冬氨酸水凝胶联合MenSCs	富含多种生长因子和细胞因子，抗炎和伤口愈合能力出色	子宫内膜再生，减少纤维化，提高生育能力	[67]

经血源性干细胞联合补肾活血类中药治疗子宫内膜功能减退类疾病的研究进展

Advancements in the Treatment of Endometrial Hypofunction Diseases Using Menstrual Blood-derived Endometrium Stem Cells Combined with Traditional Chinese Medicine for Tonifying Kidney and Activating Blood in Regenerative Medicine

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