微生物-肠-脑轴在癫痫中的作用研究进展

doi:10.12114/j.issn.1007-9572.2025.0003

中国全科医学 ›› 2026, Vol. 29 ›› Issue (32): 4821-4826.DOI: 10.12114/j.issn.1007-9572.2025.0003

微生物-肠-脑轴在癫痫中的作用研究进展

李静¹^,², 刘子琦³^,⁴, 钱莉³^,⁴^,^*(), 姚瑞芹¹^,²^,^*()

1．221004　江苏省徐州市，徐州医科大学
2．221004　江苏省徐州市神经生物学重点实验室
3．225001　江苏省扬州市，扬州大学
4．225001　江苏省扬州市，扬州大学医学院核酸与细胞命运调控省高校重点实验室

收稿日期:2025-01-20 修回日期:2025-02-14 出版日期:2026-11-15 发布日期:2026-10-10
通讯作者: 钱莉, 姚瑞芹
作者贡献：
李静负责文献资料的收集与整理、文章整体构思设计以及撰写；刘子琦负责文章质量审校；钱莉和姚瑞芹负责论文指导和经费获取。
基金资助:
江苏省研究生科研创新计划(KYCX22_2869)

Research Progress on the Role of the Microbiota-gut-brain Axis in Epilepsy

LI Jing¹^,², LIU Ziqi³^,⁴, QIAN Li³^,⁴^,^*(), YAO Ruiqin¹^,²^,^*()

1. Xuzhou Medical University, Xuzhou 221004, China
2. Xuzhou Key Laboratory of Neurobiology, Xuzhou 221004, China
3. Yangzhou University, Yangzhou 225001, China
4. Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid & Cell Fate Regulation (Yangzhou University), Faculty of Medicine, Yangzhou University, Yangzhou 225001, China

Received:2025-01-20 Revised:2025-02-14 Published:2026-11-15 Online:2026-10-10
Contact: QIAN Li, YAO Ruiqin

摘要/Abstract

摘要： 癫痫是一种以反复发作、无端发作为特征的慢性神经系统疾病，影响着全世界5 000多万人的健康，近30%的癫痫患者无法用药物控制。值得注意的是，有炎症性肠病患者更容易患癫痫。肠脑轴是指肠道与大脑之间的双向交流，通过神经网络和神经内分泌、免疫、炎症等途径调节肠道内稳态和中枢神经系统。最近的研究表明，肠道功能障碍以及生态失调可能与癫痫的发病机制和易感性有关。此外，粪便微生物群移植、益生菌干预和生酮饮食等方式重建肠道微生物群在顽固性癫痫治疗中展现出良好的效果，进一步支持了肠道菌群与癫痫之间可能的联系。本文介绍了微生物-肠-脑轴，综合既往研究中已知的肠道微生物群在癫痫发病和治疗中的作用，为探讨基于肠道微生物群的癫痫治疗新方案提供参考。

关键词: 癫痫, 微生物-肠-脑轴, 肠道微生物群, 综述

Abstract:

Epilepsy is a chronic neurological disorder characterized by recurrent, unprovoked seizures, affecting over 50 million people's health worldwide, with nearly 30% of patients unable to achieve seizure control through medication. Notably, individuals with inflammatory bowel disease are at a higher risk of developing epilepsy. The gut-brain axis refers to the bidirectional communication between the gut and the brain, regulating intestinal homeostasis and central nervous system function through neural networks, neuroendocrine, immune, and inflammatory pathways. Recent studies suggested that gut dysfunction and dysbiosis might play a role in the pathogenesis and susceptibility of epilepsy. Additionally, interventions such as fecal microbiota transplantation, probiotic therapy, and ketogenic diets, which aim to restore gut microbiota balance, have shown promising effects in the treatment of refractory epilepsy, further supporting a potential link between the gut microbiota and epilepsy. This paper describes the microbial-gut-brain axis, synthesizing what is known from previous studies about the role of the gut microbiota in the pathogenesis and treatment of epilepsy, to inform the exploration of new gut microbiota-based therapeutic options for epilepsy.

Key words: Epilepsy, Microbial-gut-brain axis, Gut microbiota, Review

中图分类号:

R 742.1

李静,刘子琦,钱莉,等. 微生物-肠-脑轴在癫痫中的作用研究进展[J]. 中国全科医学, 2026, 29(32): 4821-4826. DOI: 10.12114/j.issn.1007-9572.2025.0003.
LI Jing,LIU Ziqi,QIAN Li, et al. Research Progress on the Role of the Microbiota-gut-brain Axis in Epilepsy[J]. Chinese General Practice, 2026, 29(32): 4821-4826. DOI: 10.12114/j.issn.1007-9572.2025.0003.

参考文献 68

[1]	Beghi E, Giussani G, Sander J W. The natural history and prognosis of epilepsy[J]. Epileptic Disord, 2015, 17(3): 243-253. DOI: 10.1684/epd.2015.0751.
[2]	Beghi E. The epidemiology of epilepsy[J]. Neuroepidemiology, 2020, 54(2): 185-191. DOI: 10.1159/000503831.
[3]	Golub V M, Reddy D S. Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions[J]. Pharmacol Rev, 2022, 74(2): 387-438. DOI: 10.1124/pharmrev.121.000375.
[4]	Engel J Jr. The current place of epilepsy surgery[J]. Curr Opin Neurol, 2018, 31(2): 192-197. DOI: 10.1097/WCO.0000000000000528.
[5]	Sheng J Y, Liu S, Qin H J, et al. Drug-resistant epilepsy and surgery[J]. Curr Neuropharmacol, 2018, 16(1): 17-28. DOI: 10.2174/1570159X15666170504123316.
[6]	De Caro C, Leo A, Nesci V, et al. Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy[J]. Sci Rep, 2019, 9(1): 13983. DOI: 10.1038/s41598-019-50542-0.
[7]	López González F J, Rodríguez Osorio X, Gil-nagel Rein A, et al. Drug-resistant epilepsy: definition and treatment alternatives[J]. Neurologia, 2015, 30(7): 439-446. DOI: 10.1016/j.nrl.2014.04.012.
[8]	Gong X, Liu X, Chen C, et al. Alteration of gut microbiota in patients with epilepsy and the potential index as a biomarker[J]. Front Microbiol, 2020, 11: 517797. DOI: 10.3389/fmicb.2020.517797.
[9]	Şafak B, Altunan B, Topçu B, et al. The gut microbiome in epilepsy[J]. Microb Pathog, 2020, 139: 103853. DOI: 10.1016/j.micpath.2019.103853.
[10]	Peng A J, Qiu X M, Lai W L, et al. Altered composition of the gut microbiome in patients with drug-resistant epilepsy[J]. Epilepsy Res, 2018, 147: 102-107. DOI: 10.1016/j.eplepsyres.2018.09.013.
[11]	Citraro R, Lembo F, De Caro C, et al. First evidence of altered microbiota and intestinal damage and their link to absence epilepsy in a genetic animal model, the WAG/Rij rat[J]. Epilepsia, 2021, 62(2): 529-541. DOI: 10.1111/epi.16813.
[12]	Mayer E A, Knight R, Mazmanian S K, et al. Gut microbes and the brain: paradigm shift in neuroscience[J]. J Neurosci, 2014, 34(46): 15490-15496. DOI: 10.1523/JNEUROSCI.3299-14.2014.
[13]	Claudino Dos Santos J C, Oliveira L F, Noleto F M, et al. Gut-microbiome-brain axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson's disease[J]. Neural Regen Res, 2023, 18(12): 2611-2614. DOI: 10.4103/1673-5374.373673.
[14]	Basiji K, Sendani A A, Ghavami S B, et al. The critical role of gut-brain axis microbiome in mental disorders[J]. Metab Brain Dis, 2023, 38(8): 2547-2561. DOI: 10.1007/s11011-023-01248-w.
[15]	Iannone L F, Preda A, Blottière H M, et al. Microbiota-gut brain axis involvement in neuropsychiatric disorders[J]. Expert Rev Neurother, 2019, 19(10): 1037-1050. DOI: 10.1080/14737175.2019.1638763.
[16]	Quigley E M M. Microbiota-brain-gut axis and neurodegenerative diseases[J]. Curr Neurol Neurosci Rep, 2017, 17(12): 94. DOI: 10.1007/s11910-017-0802-6.
[17]	Adak A, Khan M R. An insight into gut microbiota and its functionalities[J]. Cell Mol Life Sci, 2019, 76(3): 473-493. DOI: 10.1007/s00018-018-2943-4.
[18]	Bäckhed F, Roswall J, Peng Y Q, et al. Dynamics and stabilization of the human gut microbiome during the first year of life[J]. Cell Host Microbe, 2015, 17(5): 690-703. DOI: 10.1016/j.chom.2015.04.004.
[19]	Rinninella E, Raoul P, Cintoni M, et al. What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases[J]. Microorganisms, 2019, 7(1): 14. DOI: 10.3390/microorganisms7010014.
[20]	Yamashiro Y. Gut microbiota in health and disease[J]. Ann Nutr Metab, 2017, 71(3/4): 242-246. DOI: 10.1159/000481627.
[21]	Carabotti M, Scirocco A, Maselli M A, et al. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems[J]. Ann Gastroenterol, 2015, 28(2): 203-209.
[22]	Wang H X, Wang Y P. Gut microbiota-brain axis [J]. Chin Med J(Engl), 2016, 129(19): 2373-80.
[23]	Silva Y P, Bernardi A, Frozza R L. The role of short-chain fatty acids from gut microbiota in gut-brain communication[J]. Front Endocrinol, 2020, 11: 25. DOI: 10.3389/fendo.2020.00025.
[24]	Gareau M G. Microbiota-gut-brain axis and cognitive function[J]. Adv Exp Med Biol, 2014, 817: 357-371. DOI: 10.1007/978-1-4939-0897-4_16.
[25]	Dinan T G, Cryan J F. The microbiome-gut-brain axis in health and disease[J]. Gastroenterol Clin North Am, 2017, 46(1): 77-89. DOI: 10.1016/j.gtc.2016.09.007.
[26]	Lindefeldt M, Eng A, Darban H, et al. The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy[J]. NPJ Biofilms Microbiomes, 2019, 5(1): 5. DOI: 10.1038/s41522-018-0073-2.
[27]	Lum G R, Olson C A, Hsiao E Y. Emerging roles for the intestinal microbiome in epilepsy[J]. Neurobiol Dis, 2020, 135: 104576. DOI: 10.1016/j.nbd.2019.104576.
[28]	Molina-Torres G, Rodriguez-Arrastia M, Roman P, et al. Stress and the gut microbiota-brain axis[J]. Behav Pharmacol, 2019, 30(2 and 3-Spec Issue): 187-200. DOI: 10.1097/FBP.0000000000000478.
[29]	Yamanaka G, Morichi S, Takamatsu T, et al. Links between immune cells from the periphery and the brain in the pathogenesis of epilepsy: a narrative review[J]. Int J Mol Sci, 2021, 22(9): 4395. DOI: 10.3390/ijms22094395.
[30]	Khakh B S, Sofroniew M V. Diversity of astrocyte functions and phenotypes in neural circuits[J]. Nat Neurosci, 2015, 18(7): 942-952. DOI: 10.1038/nn.4043.
[31]	Ginhoux F, Lim S, Hoeffel G, et al. Origin and differentiation of microglia[J]. Front Cell Neurosci, 2013, 7: 45. DOI: 10.3389/fncel.2013.00045.
[32]	Ding X M, Zhou J, Zhao L, et al. Intestinal flora composition determines microglia activation and improves epileptic episode progress[J]. Front Cell Infect Microbiol, 2022, 12: 835217. DOI: 10.3389/fcimb.2022.835217.
[33]	Rothhammer V, Borucki D M, Tjon E C, et al. Microglial control of astrocytes in response to microbial metabolites[J]. Nature, 2018, 557(7707): 724-728. DOI: 10.1038/s41586-018-0119-x.
[34]	Djukic M, Mildner A, Schmidt H, et al. Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice[J]. Brain, 2006, 129(Pt 9): 2394-2403. DOI: 10.1093/brain/awl206.
[35]	Moradi K, Ashraf-Ganjouei A, Tavolinejad H, et al. The interplay between gut microbiota and autism spectrum disorders: a focus on immunological pathways[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2021, 106: 110091. DOI: 10.1016/j.pnpbp.2020.110091.
[36]	Gaman A, Kuo B. Neuromodulatory processes of the brain-gut axis[J]. Neuromodulation, 2008, 11(4): 249-259. DOI: 10.1111/j.1525-1403.2008.00172.x.
[37]	Kaelberer M M, Buchanan K L, Klein M E, et al. A gut-brain neural circuit for nutrient sensory transduction[J]. Science, 2018, 361(6408): eaat5236. DOI: 10.1126/science.aat5236.
[38]	Goehler L E, Gaykema R P A, Opitz N, et al. Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni[J]. Brain Behav Immun, 2005, 19(4): 334-344. DOI: 10.1016/j.bbi.2004.09.002.
[39]	Attenello F, Amar A P, Liu C, et al. Theoretical basis of vagus nerve stimulation[J]. Prog Neurol Surg, 2015, 29: 20-28. DOI: 10.1159/000434652.
[40]	Ressler K J, Mayberg H S. Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic[J]. Nat Neurosci, 2007, 10(9): 1116-1124. DOI: 10.1038/nn1944.
[41]	Werner F M, Coveñas R. Classical neurotransmitters and neuropeptides involved in generalized epilepsy in a multi-neurotransmitter system: how to improve the antiepileptic effect?[J]. Epilepsy Behav, 2017, 71(Pt B): 124-129. DOI: 10.1016/j.yebeh.2015.01.038.
[42]	Barrett E, Ross R P, O'toole P W, et al. γ-Aminobutyric acid production by culturable bacteria from the human intestine[J]. J Appl Microbiol, 2012, 113(2): 411-417. DOI: 10.1111/j.1365-2672.2012.05344.x.
[43]	Dinan T G, Stilling R M, Stanton C, et al. Collective unconscious: how gut microbes shape human behavior[J]. J Psychiatr Res, 2015, 63: 1-9. DOI: 10.1016/j.jpsychires.2015.02.021.
[44]	Wikoff W R, Anfora A T, Liu J, et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites[J]. Proc Natl Acad Sci USA, 2009, 106(10): 3698-3703. DOI: 10.1073/pnas.0812874106.
[45]	Reigstad C S, Salmonson C E, Rainey J F 3rd, et al. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells[J]. FASEB J, 2015, 29(4): 1395-1403. DOI: 10.1096/fj.14-259598.
[46]	Yano J M, Yu K, Donaldson G P, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis[J]. Cell, 2015, 161(2): 264-276. DOI: 10.1016/j.cell.2015.02.047.
[47]	Specchio L M, Iudice A, Specchio N, et al. Citalopram as treatment of depression in patients with epilepsy[J]. Clin Neuropharmacol, 2004, 27(3): 133-136. DOI: 10.1097/00002826-200405000-00009.
[48]	Den Besten G, Van Eunen K, Groen A K, et al. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism[J]. J Lipid Res, 2013, 54(9): 2325-2340. DOI: 10.1194/jlr.R036012.
[49]	Lu W, Wu Z Z, Zhang C, et al. Jujuboside A exhibits an antiepileptogenic effect in the rat model via protection against traumatic epilepsy-induced oxidative stress and inflammatory responses[J]. Evid Based Complement Alternat Med, 2022, 2022: 7792791. DOI: 10.1155/2022/7792791.
[50]	Cheng Y H, Mai Q T, Zeng X, et al. Propionate relieves pentylenetetrazol-induced seizures, consequent mitochondrial disruption, neuron necrosis and neurological deficits in mice[J]. Biochem Pharmacol, 2019, 169: 113607. DOI: 10.1016/j.bcp.2019.08.009.
[51]	Li D Y, Bai X Y, Jiang Y, et al. Butyrate alleviates PTZ-induced mitochondrial dysfunction, oxidative stress and neuron apoptosis in mice via Keap1/Nrf2/HO-1 pathway[J]. Brain Res Bull, 2021, 168: 25-35. DOI: 10.1016/j.brainresbull.2020.12.009.
[52]	Yeom J S, Park J S, Kim Y S, et al. Neonatal seizures and white matter injury: role of rotavirus infection and probiotics[J]. Brain Dev, 2019, 41(1): 19-28. DOI: 10.1016/j.braindev.2018.07.001.
[53]	Eor J Y, Son Y J, Kim J Y, et al. Neuroprotective effect of both synbiotics and ketogenic diet in a pentylenetetrazol-induced acute seizure murine model[J]. Epilepsy Res, 2021, 174: 106668. DOI: 10.1016/j.eplepsyres.2021.106668.
[54]	Buffington S A, Dooling S W, Sgritta M, et al. Dissecting the contribution of host genetics and the microbiome in complex behaviors[J]. Cell, 2021, 184(7): 1740-1756.e16. DOI: 10.1016/j.cell.2021.02.009.
[55]	Tahmasebi S, Oryan S, Mohajerani H R, et al. Probiotics and Nigella sativa extract supplementation improved behavioral and electrophysiological effects of PTZ-induced chemical kindling in rats[J]. Epilepsy Behav, 2020, 104(Pt A): 106897. DOI: 10.1016/j.yebeh.2019.106897.
[56]	Watanangura A, Meller S, Farhat N, et al. Behavioral comorbidities treatment by fecal microbiota transplantation in canine epilepsy: a pilot study of a novel therapeutic approach[J]. Front Vet Sci, 2024, 11: 1385469. DOI: 10.3389/fvets.2024.1385469.
[57]	Van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile[J]. N Engl J Med, 2013, 368(5): 407-415. DOI: 10.1056/NEJMoa1205037.
[58]	Fischer M, Sipe B, Cheng Y W, et al. Fecal microbiota transplant in severe and severe-complicated Clostridium difficile: a promising treatment approach[J]. Gut Microbes, 2017, 8(3): 289-302.
[59]	He Z, Cui B T, Zhang T, et al. Fecal microbiota transplantation cured epilepsy in a case with Crohn's disease: the first report[J]. World J Gastroenterol, 2017, 23(19): 3565-3568. DOI: 10.3748/wjg.v23.i19.3565.
[60]	Li X Y, Li J, Ji J, et al. Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy[J]. J Neurochem, 2024, 168(12): 3982-4000. DOI: 10.1111/jnc.16033.
[61]	Mengoli M, Conti G, Fabbrini M, et al. Microbiota-gut-brain axis and ketogenic diet: how close are we to tackling epilepsy?[J]. Microbiome Res Rep, 2023, 2(4): 32. DOI: 10.20517/mrr.2023.24.
[62]	Pluta R, Jabłoński M. The ketogenic diet for epilepsy therapy in children: quo vadis?[J]. Nutrition, 2011, 27(5): 615-616. DOI: 10.1016/j.nut.2010.12.015.
[63]	Fan Y Y, Wang H, Liu X Y, et al. Crosstalk between the ketogenic diet and epilepsy: from the perspective of gut microbiota[J]. Mediators Inflamm, 2019, 2019: 8373060. DOI: 10.1155/2019/8373060.
[64]	Barzegar M, Afghan M, Tarmahi V, et al. Ketogenic diet: overview, types, and possible anti-seizure mechanisms[J]. Nutr Neurosci, 2021, 24(4): 307-316. DOI: 10.1080/1028415X.2019.1627769.
[65]	Kwan P, Brodie M J. Early identification of refractory epilepsy[J]. N Engl J Med, 2000, 342(5): 314-319. DOI: 10.1056/NEJM200002033420503.
[66]	Freeman J M, Kossoff E H, Hartman A L. The ketogenic diet: one decade later[J]. Pediatrics, 2007, 119(3): 535-543. DOI: 10.1542/peds.2006-2447.
[67]	Melø T M, Nehlig A, Sonnewald U. Neuronal-glial interactions in rats fed a ketogenic diet[J]. Neurochem Int, 2006, 48(6/7): 498-507. DOI: 10.1016/j.neuint.2005.12.037.
[68]	Qiao Y N, Li L, Hu S H, et al. Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy[J]. Cell Discov, 2024, 10(1): 17. DOI: 10.1038/s41421-023-00636-x.

微生物-肠-脑轴在癫痫中的作用研究进展

Research Progress on the Role of the Microbiota-gut-brain Axis in Epilepsy

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[15]	李文萍, 陈建华, 许家培, 金雪, 潘子涵, 迟春花. 数智化健康管理平台赋能社区老年人健康服务的范围综述[J]. 中国全科医学, 2026, 29(21): 2938-2949.