关键词: 消化性溃疡出血, 胃镜检查, 奥美拉唑, 止血, 剂量, 治疗结果

Abstract: Objective　To explore the clinical effect of endoscopic hemostasis combined with intravenous administration of different doses of esomeprazole sodium on acute peptic ulcer bleeding（APUB）.Methods　We enrolled 160 inpatients with APUB from Department of Gastroenterology，General Hospital of Chinese People's Armed Police Force from January 2016 to January 2018 and equally divided them into standard-dose group（study group） and large-dose group（control group） by the random number table.Based on endoscopic hemostasis，the study group received 3-day management including intravenous injection of esomeprazole sodium 80 mg combined with intravenous drip of esomeprazole sodium 40 mg，once every 12 hours，and the control group received 3-day management consisting of intravenous injection of esomeprazole sodium 80 mg combined with continuous infusion of esomeprazole sodium 8 mg/h by the infusion pump.We compared the indicators for evaluating the treatment effectiveness such as mean time needed for bleeding to stop，mean amount of blood transfusion，rate of re-bleeding，mean length of stay，rate of having adverse events，and rate of receiving surgical intervention between the groups.Results　Both groups showed no significant differences in the aforementioned indicators for evaluating the treatment effectiveness（P>0.05）.Conclusion　Although both regimens achieved similar hemostatic effects，we recommend intravenous administration of standard dose of esomeprazole sodium in combination with endoscopic hemostasis，for it uses less medical resources.

Key words: Peptic ulcer hemorrhage, Gastroscopy, Omeprazole, Hemostasis, Dose, Treatment outcome