关键词: 帕金森病, 氧化性应激, 生物学标记

Abstract: Objective　To investigate the level of oxidative stress biomarkers in plasma and the severity of Parkinson's disease（PD）.Methods　The participants enrolled were all from Fujian Provincial Hospital between December 2016 and June 2017，including 40 outpatients and inpatients with idiopathic PD from Department of Neurology〔23 with mild PD （mild PD subgroup） and 17 with moderate-to-severe PD（moderate-to-severe PD subgroup）classified by Hoehn and Yahr Scale〕，and 40 health individuals without biological relatives with PD undergoing physical examination （control group）.The levels of malondialdehyd（MDA），8-hydroxy-2-deoxyguanosine（8-OHdG）and DJ-1 protein were compared between the mild，moderate-to-severe PD patients and controls.Results　（1）The average levels of MDA and 8-OHdG differed significantly between mild，moderate-to-severe PD patients and controls（P<0.05）.To be specific，compared with the controls，mild and moderate-to-severe PD patients demonstrated much higher average MDA levels，and mild PD patients presented significantly higher average 8-OHdG levels（P<0.05）.（2）The average DJ-1 protein levels were similar in the controls and the PD patients（P>0.05）.Conclusion　Elevated MDA can be found in PD patients.Moreover，increased 8-OHdG can also be found in mild PD patients.

Key words: Parkinson's disease, Oxidative stress, Biomarkers