关键词: 有机磷化合物, 中毒, 认知障碍, 神经心理学

Abstract: Objective　To investigate the effect of acute moderately severe organophosphorus pesticides poisoning on cognitive function.Methods　29 patients with acute moderately severe organophosphorus pesticides poisoning,who had been hospitalized in Department of Emergency Internal Medicine of the Second Hospital of Anhui Medical University from November 2010 to October 2014 and met the inclusion criteria,were selected as the research group,and 29 healthy volunteers after physical examination in the same hospital during the same period were also enrolled as the control group.Patients in research group received corresponding treatment like timely gastric lavage.All patients’ cognitive function were evaluated by the Montreal Cognitive Assessment （MoCA）.The MoCA various dimensional score and total score of control group at the enrolling time and of research group 1 week,1 month and 6 months after treatment were compared in this study.Results　The MoCA total score of 1 month and 6 months after treatment was higher than that of 1 week after treatment in the research group （P<0.05）;the MoCA total score of 6 months after treatment was higher than that of 1 month after treatment in the research group （P<0.05）.The MoCA total score of the research group 1 week and 1 month after treatment was lower than that of the control group （P<0.05）;there was no significant difference in the MoCA total score between the research group 6 months after treatment and the control group （P>0.05）.In the research group,the scores of naming,attention,abstraction,delayed recall and orientation of 1 month and 6 months after treatment were higher than those 1 week after treatment,and the scores of visual space and executive function and language 6 months after treatment were higher than those 1 week after treatment （P<0.05）;the scores of visual space and executive function,attention,language,abstraction,delayed recall and orientation 6 months after treatment were higher than those 1 month after treatment （P<0.05）.The scores of visual space and executive function,naming,attention,language,abstraction,delayed recall and orientation in the control group were higher than those in the research group 1 week after treatment （P<0.05）;the scores of attention,language,delayed recall and orientation in the control group were higher than those in the research group 1 month after treatment （P<0.05）;the scores of attention and delayed recall of the control group were higher than those of the research group 6 months after treatment,while their score of language was lower than that of the research group 6 months after treatment （P<0.05）.Conclusion　The acute moderately severe organophosphorus pesticide poisoning will lead to cognitive function impairment.Although the MoCA total scores of 6 months after treatment return to normal state,their cognitive function of attention and delayed recall are still poor.

Key words: Organophosphorus compounds, Poisoning, Cognition disorder, Neuropsychology