关键词: 认知障碍, 铜稳态, 铜代谢, 铜死亡, 综述

Abstract: Cognitive impairment is often manifested as a series of brain function deficits such as learning，memory， intellectual，emotional，and executive deficits. It often occurs in neurological disorders，aging，and the postoperative period. Currently，the pathogenesis of the disease is unclear，and the blood-brain barrier，oxidative stress，autophagy， inflammation，mitochondria，and neurotransmitters have all been implicated in cognitive dysfunction. Recent studies have found that copper homeostasis associated with copper metabolism and copper death has a regulatory role in cognitive function， which may be a key mechanism in the development of cognitive impairment. In this paper，we systematically introduce the role of copper homeostasis regulatory mechanisms in cognitive impairment from the perspectives of mitochondria，glial cells，oxidative reactions，inflammatory factors，neurotransmitters，etc.（when copper homeostasis is imbalanced，copper ion levels are disturbed，electrolyte metabolism is abnormal，and a series of reactions，such as oxidative stress，inflammatory aggregation， mitochondrial disorders，and glial cell damage，occur，and even induce neuronal copper death）and summarise the role of copper homeostasis in cognitive impairment. The role of copper homeostasis in cognitive disorders is summarised， to provide new insights into the pathogenesis of cognitive disorders，as well as bringing new solutions to the treatment of the disease.

Key words: Cognitive impairment, Copper steady state, Copper metabolism, Copper death, Review