血尿酸与非酒精性脂肪肝的相关性研究进展

doi:10.3969/j.issn.1007-9572.2018.00.232

摘要/Abstract

摘要： 近年来非酒精性脂肪肝（NAFLD）已经成为全球性慢性肝脏疾病常见的原因。随着研究的深入，人们对NAFLD的认识不再局限于肝脏本身，而是把其作为代谢综合征（MS）在肝脏的主要表现，与心血管疾病（CVD）、慢性肾脏疾病（CKD）等代谢性疾病密切相关，甚至可以作为全身性疾病的预测信号。越来越多的证据表明，血尿酸（SUA）的增加可以引起全身性代谢紊乱，包括MS、NAFLD等。本文结合SUA病理生理作用与NAFLD流行病学特点、机制等，综述了SUA与NAFLD的相关性，为NAFLD的早期发现、有效管理与监测提供理论支持。

关键词: 脂肪肝, 尿酸, 综述

Abstract: In recent years，nonalcoholic fatty liver disease（NAFLD）has been found to be a common cause of chronic liver disease all over the world.With the development of medical studies，NAFLD is no longer considered as a disorder only involves the liver，but main manifestations of the liver secondary to metabolic syndrome（MS）.NAFLD is closely associated with cardiovascular disease，chronic kidney disease and other metabolic diseases，and even can be used as a predictor for systemic disease.Increasing evidence show that elevated serum uric acid（SUA）may play a role in the development of MS，NAFLD and other systemic metabolic disorders.We reviewed the correlations between SUA and NAFLD based on analyzing the pathophysiology of SUA and epidemiological characteristics and mechanisms of NAFLD，with a view to providing theoretical support for early detection，effective management and monitoring of NAFLD.

Key words: Fatty liver, Uric acid, Review

王丽莹,李强. 血尿酸与非酒精性脂肪肝的相关性研究进展[J]. 中国全科医学, 2018, 21(27): 3397-3402. DOI: 10.3969/j.issn.1007-9572.2018.00.232.
WANG Li-ying,LI Qiang. Recent Advances in the Correlation between Serum Uric Acid and Nonalcoholic Fatty Liver Disease[J]. Chinese General Practice, 2018, 21(27): 3397-3402. DOI: 10.3969/j.issn.1007-9572.2018.00.232.

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