关键词: 乳腺肿瘤, 复发, 中性粒细胞/淋巴细胞比值, 血小板/淋巴细胞比值, 预后

Abstract: Objective　To evaluate the clinical value of neutrophil-to-lymphocyte ratio （NLR） and platelet-to-lymphocyte ratio （PLR） in predicting the recurrence and metastasis of breast cancer,and to explore influencing factors of the prognosis of patients with breast cancer.Methods　The clinical data of 154 patients with primary invasive breast cancer （patients group） who underwent surgery in Yangpu Hospital,Tongji University from 2007 to 2010 were retrospectively analyzed,and the relationship between PLR,NLR and different clinical features before surgery was analyzed,and the ROC curve of NLR and PLR in predicting recurrence and metastasis of breast cancer was drawn,Kaplan-Meier method was used to draw survival curves,and Cox regression model was used to analyze influencing factors of the prognosis of patients with breast cancer.45 patients who underwent benign breast surgery at the same period were selected as the control group.Results　During the median follow-up of 80 months of patients in patients group,a total of 15 patients died,19 patients had recurrence and metastasis.NLR and PLR of peripheral blood before surgery in patients group were higher than those in control group （P<0.05）.There was significant difference in NLR among patients with different pathological types and with or without lymphatic metastasis in patients group （P<0.05）.There was significant difference in PLR among patients with different ages and with or without lymphatic metastasis in patients group （P<0.05）.The critical value of NLR predicting recurrence and metastasis of breast cancer was 2.56,the sensitivity and specificity were 55.4% and 86.5% respectively,and area under the curve of ROC was 0.738〔95%CI（0.657,0.818）〕;the critical value of PLR predicting recurrence and metastasis of breast cancer was 123.85,the sensitivity and specificity were 67.7% and 58.4% respectively,and area under the curve of ROC was 0.651〔95%CI（0.563,0.738）〕.There was significant difference in disease free survival curve and overall survival curve between patients with or without lymphatic metastasis （P<0.05）.Cox regression model analysis presented that recurrence and metastasis,survival condition of patients with breast cancer were not significantly influenced by and NLR and PLR （P>0.05）,lymphatic metastasis found during the operation was the independent influencing factor of breast cancer patients’ survival condition.Conclusion　Preoperative NLR and PLR can predict recurrence metastasis status,but they cannot be the effective index for predicting recurrence and metastasis and prognosis of breast cancer.

Key words: Breast neoplasms, Recurrence, Neutrophil-lymphocyte ratio, Platelet-lymphocyte ratio, Prognosis