关键词: 人体质量指数, 脂肪肝, 危险因素

Abstract: Objective　To investigate risk factors of nonalcoholic fatty liver disease （NAFLD） of non-overweight people.Methods　Among 1 337 workers of a company who had taken physical examination in Beijing Shijitan Hospital,Capital Medical University,747 non-overweight people were selected.According to whether people suffered from NAFLD or not,they were divided into NAFLD group （n=210） and control group （n=537）.Blood routine,fasting plasma glucose （FPG）,blood lipids,liver function and serum uric acid （SUA） of all the subjects were detected,and 20 subjects in the two groups were randomly selected to test the levels of plasma interleukin-6 （IL-6）,tumor necrosis factor-α （TNF-α）,granulocyte-macrophage colony stimulating factor （GM-CSF）.Results　There was no significant difference in gender and age between two groups （P>0.05）;while there was significant difference in BMI,waist,white blood cell count （WBC）,direct bilirubin （DBIL）,FPG,triglyceride （TG）,high density lipoprotein cholesterol （HDL-C）,ALT,AST,alkaline phosphatase （ALP） and SUA （P<0.05）.Multivariate Logistic regression analysis showed that waist,DBIL,HDL-C and SUA were the influencing factors of non-overweight people suffering from NAFLD （P<0.05）.Levels of plasma IL-6,TNF-α and GM-CSF in NAFLD group were significantly higher than those in control group （P<0.05）.Conclusion　The risk factors of people suffering from NAFLD are increased waist,elevated level of SUA and lowered level of DBIL and HDL-C;in the meanwhile,multiple inflammatory cytokines may involve in the occurrence and development of the disease.

Key words: Body mass index, Fatty liver, Risk factors