关键词: 血浆致动脉硬化指数, 心力衰竭, 危险因素

Abstract: Background　Heart failure (HF) is the end stage of a variety of cardiovascular diseases, high incidence, poor prognosis, seriously affect the quality of life of patients. The atherogenic index of plasma (AIP) is closely related to atherosclerosis, coronary heart disease and other cardiovascular diseases, and atherosclerosis is an important risk factor for heart failure. Objective　To investigate the effect of the AIP index on the risk of new-onset HF. Methods　This is a prospective cohort study. 99 755 active and retired employees of Kailuan Group who participated in the health examination of the Kailuan Study from June 2006 to October 2007 were selected as the observation population, and the subjects were divided into 4 groups according to baseline AIP quartile. Follow-up will continue until 31 December 2021, during which the incidence of HF will be recorded once a year. The incidence density of HF in the 4 groups was calculated. The cumulative incidence of HF in the 4 groups was calculated using the Kaplan-Meier method. The effect of AIP on the risk of new-onset HF was analysed by Cox regression. Results　During a mean follow-up of 14.07 (13.79, 14.24) years, there were 3 337 (3.35%) cases of new HF. There were 675, 734, 940 and 988 cases in group Q1-Q4, respectively, and the incidence density was 1.95/1000, 2.13/1000, 2.73/1000 and 2.87/1000 years, respectively. With increasing AIP level, the cumulative incidence of new HF in the Q1-Q4 group was 2.47%, 2.68%, 3.48% and 3.63%, respectively. According to the log-rank test, the differences were statistically significant (P <0.001). In multivariate Cox regression analysis, after adjustment for age, sex, and traditional HF risk factors, compared with Q1, the HR (95%CI) for new-onset HF in Q3-Q4 was 1.16 (1.05-1.28) and 1.20 (1.08-1.33), respectively, and the differences were statistically significant (P <0.05). Conclusion　AIP is an independent risk factor for new HF. Early screening, evaluation and intervention of patients at high risk of HF can be achieved through AIP.

Key words: The Atherogenic Index of Plasma, Heart failure, Risk factor