创伤性中枢神经系统损伤后肠道屏障变化及其可能机制的研究进展

doi:10.12114/j.issn.1007-9572.2023.0293

中国全科医学 ›› 2024, Vol. 27 ›› Issue (14): 1775-1781.DOI: 10.12114/j.issn.1007-9572.2023.0293

创伤性中枢神经系统损伤后肠道屏障变化及其可能机制的研究进展

王芳芳¹^,², 朱莉¹^,², 幸佳佳¹^,², 庞日朝², 苟翔², 张安仁³^,^*()

1．610075　四川省成都市，成都中医药大学养生康复学院
2．610083　四川省成都市，中国人民解放军西部战区总医院康复医学科
3．200434　上海市，同济大学附属上海市第四人民医院康复医学科

收稿日期:2023-03-05 修回日期:2023-06-18 出版日期:2024-05-15 发布日期:2024-03-22
通讯作者: 张安仁
作者贡献：
王芳芳提出研究选题方向，进行论文的构思与设计、文献及资料的整理，并撰写论文初稿；朱莉、幸佳佳负责检索和汇总文献及资料；苟翔对初稿进行修订；庞日朝、张安仁负责论文的质量控制及审校，对论文整体负责；所有作者确认了论文的最终稿。
基金资助:
国家自然科学基金面上项目(81973927); 四川省中医药管理局科学技术研究专项(2021MS257)

Research Progress on the Changes of Intestinal Barrier and Possible Mechanism after Traumatic Central Nervous System Injury

WANG Fangfang¹^,², ZHU Li¹^,², XING Jiajia¹^,², PANG Rizhao², GOU Xiang², ZHANG Anren³^,^*()

1. School of Health and Rehabilitation, Chengdu University of TCM, Chengdu 610075, China
2. Department of Rehabilitation Medicine, the General Hospital of Western Theater Command PLA, Chengdu 610083, China
3. Department of Rehabilitation Medicine, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai 200434, China

Received:2023-03-05 Revised:2023-06-18 Published:2024-05-15 Online:2024-03-22
Contact: ZHANG Anren

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摘要/Abstract

摘要： 创伤性中枢神经系统损伤可通过破坏肠道屏障功能进而引起肠道微环境稳态失衡，而紊乱的肠道微环境可反作用于中枢，加重中枢神经系统继发性损伤。大量研究提示，肠道屏障在创伤性中枢神经损伤的病理生理过程中起重要作用，可作为中枢神经损伤的重要作用靶点。本文综述了创伤性中枢神经系统损伤后肠道微生物、化学、机械和免疫屏障结构和功能的变化及其与中枢的双向作用，并总结了致使肠屏障破坏的可能机制，包括营养不良、缺血再灌注损伤、炎性反应及神经递质和激素释放等，为创伤性中枢神经损伤后肠道微环境的研究开展提供一定的理论依据和新思路。

关键词: 中枢神经系统疾病, 创伤性中枢神经系统损伤, 肠道屏障, 肠道微环境, 肠-脑轴, 综述

Abstract:

Traumatic central nervous system injury can cause imbalance in intestinal microenvironmental homeostasis by disrupting intestinal barrier function, while the disturbed intestinal microenvironment can react on the central nervous system and aggravate the secondary injury of it. A large number of studies suggest that the intestinal barrier plays an important role in the pathophysiological process of traumatic central nervous system injury and can be an important target for the action of central nervous system injury. This paper reviews the structural and functional changes of intestinal microbial, chemical, mechanical and immune barriers after traumatic central nervous system injury and their bidirectional interaction with the central nervous system, summarizes the possible mechanisms leading to the disruption of intestinal barrier, including malnutrition, ischemia-reperfusion injury, inflammatory response and the release of neurotransmitters and hormones, to provide theoretical basis and new ideas for the development of research on the intestinal microenvironment after traumatic central nervous injury.

Key words: Central nervous system diseases, Traumatic central nervous system injury, Intestinal barrier, Intestinal microenvironment, Gut-brain axis, Review

中图分类号:

R 742.89

王芳芳,朱莉,幸佳佳,等. 创伤性中枢神经系统损伤后肠道屏障变化及其可能机制的研究进展[J]. 中国全科医学, 2024, 27(14): 1775-1781. DOI: 10.12114/j.issn.1007-9572.2023.0293.
WANG Fangfang,ZHU Li,XING Jiajia, et al. Research Progress on the Changes of Intestinal Barrier and Possible Mechanism after Traumatic Central Nervous System Injury[J]. Chinese General Practice, 2024, 27(14): 1775-1781. DOI: 10.12114/j.issn.1007-9572.2023.0293.

图/表 1

参考文献 54

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创伤性中枢神经系统损伤后肠道屏障变化及其可能机制的研究进展

Research Progress on the Changes of Intestinal Barrier and Possible Mechanism after Traumatic Central Nervous System Injury

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