中国全科医学 ›› 2021, Vol. 24 ›› Issue (36): 4580-4586.DOI: 10.12114/j.issn.1007-9572.2021.02.036
所属专题: 衰弱最新文章合集; 老年问题最新文章合集
李可欣1,吕静1*,于冰1,罗浩铭2
出版日期:
2021-12-20
发布日期:
2021-12-20
基金资助:
LI Kexin1,LYU Jing1*,YU Bing1,LUO Haoming2
Published:
2021-12-20
Online:
2021-12-20
摘要: 衰弱已被视为一个重大的公共卫生问题,相对于大规模筛查老年衰弱的量表类工具而言,生物标志物可以更早、更客观地识别衰弱高危人群。本文对与衰弱相关的炎症、内分泌、氧化应激标志物等传统生物标志物的新进展以及存在的局限性进行综述,并对蛋白质生物标志物、表观遗传标记、神经元标志物、细胞外水分率比值等新兴标志物的潜在性进行探讨,提出标志物与功能参数结合、建立衰弱核心标志物小组、针对衰弱的过程状态选择不同的标志物等评估衰弱的新方法,应探索有价值的衰弱生物标志物补充到已有的研究中,有利于阐明衰弱的发病机制,对衰弱的预防、诊断及预后具有重要作用。
LI Kexin,LYU Jing,YU Bing,LUO Haoming. Emerging Markers of Frailty in Older People: Recent Strides and Prospect [J]. Chinese General Practice, 2021, 24(36): 4580-4586.
[1] | 郝秋奎,李峻,董碧蓉,等. 老年患者衰弱评估与干预中国专家共识[J].中华老年医学杂志,2017,36(3):251-256. DOI:CNKI:SUN:ZHLN.0.2017-03-007. |
[2] | TANAKA S, ANDO K, KOBAYASHI K,et al. Higher extracellular water-to-total body water ratio more strongly reflects the locomotive syndrome risk and frailty than sarcopenia[J]. Arch Gerontol Geriatr,2020,88: 104042. DOI:10.1016/j.archger.2020.104042. |
[3] | 田鹏,杨宁,郝秋奎,等. 中国老年衰弱患病率的系统评价[J]. 中国循证医学杂志,2019,19(6): 656-664. |
[4] | 孙凯旋. 老年衰弱综合征影响因素分析及与血清25羟维生素D关系的研究[D]. 扬州: 扬州大学,2018. |
[5] | SÁNCHEZ-FLORES M, MARCOS-PÉREZ D, COSTA S,et al. Oxidative stress,genomic features and DNA repair in frail elderly: a systematic review[J]. Ageing Res Rev,2017,37: 1-15. DOI:10.1016/j.arr.2017.05.001. |
[6] | TEIXEIRA-GOMES A, LAGE B, ESTEVES F,et al. Frailty syndrome,biomarkers and environmental factors-a pilot study[J]. Toxicol Lett,2020,330: 14-22. DOI:10.1016/j.toxlet.2020.04.023. |
[7] | 杨逸辉,廖力,邓祺丹. FRAIL量表和Tilburg量表在社区老年糖尿病患者衰弱评估中的应用比较[J]. 中西医结合护理:中英文,2020,6(1): 1-4. |
[8] | KANE A E, SINCLAIR D A. Frailty biomarkers in humans and rodents: current approaches and future advances[J]. Mech Ageing Dev,2019,180: 117-128. DOI:10.1016/j.mad.2019.03.007. |
[9] | SAEDI A A, FEEHAN J, PHU S,et al. Current and emerging biomarkers of frailty in the elderly[J]. Clin Interv Aging,2019,14: 389-398. DOI:10.2147/CIA.S168687. |
[10] | CARDOSO A L, FERNANDES A, AGUILAR-PIMENTEL J A,et al. Towards frailty biomarkers: candidates from genes and pathways regulated in aging and age-related diseases[J]. Ageing Res Rev,2018,47: 214-277. DOI:10.1016/j.arr.2018.07.004. |
[11] | MAILLIEZ A, GUILBAUD A, PUISIEUX F,et al. Circulating biomarkers characterizing physical frailty: CRP,hemoglobin,albumin,25OHD and free testosterone as best biomarkers. Results of a meta-analysis[J]. Exp Gerontol,2020,139: 111014. DOI:10.1016/j.exger.2020.111014. |
[12] | SADJAPONG U, YODKEEREE S, SUNGKARAT S,et al. Multicomponent exercise program reduces frailty and inflammatory biomarkers and improves physical performance in community-dwelling older adults: a randomized controlled trial[J]. Int J Environ Res Public Health,2020,17(11): E3760. DOI:10.3390/ijerph17113760. |
[13] | PANSARASA O, PISTONO C, DAVIN A,et al. Altered immune system in frailty: genetics and diet may influence inflammation[J]. Ageing Res Rev,2019,54: 100935. DOI:10.1016/j.arr.2019.100935. |
[14] | FURTADO G E, UBA CHUPEL M, MINUZZI L,et al. Exploring the potential of salivary and blood immune biomarkers to elucidate physical frailty in institutionalized older women[J]. Exp Gerontol,2020,129: 110759. DOI:10.1016/j.exger.2019.110759. |
[15] | 青颖. 靶向筛选精神分裂症潜在血液诊断生物标志物的研究[D]. 上海:上海交通大学,2016. |
[16] | QU T, YANG H L, WALSTON J D,et al. Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty[J]. Cytokine,2009,46(3): 319-324. DOI:10.1016/j.cyto.2009.02.015. |
[17] | SOYSAL P, STUBBS B, LUCATO P,et al. Inflammation and frailty in the elderly: a systematic review and meta-analysis[J]. Ageing Res Rev,2016,31: 1-8. DOI:10.1016/j.arr.2016.08.006. |
[18] | NASCIMENTO C M, INGLES M, SALVADOR-PASCUAL A,et al. Sarcopenia,frailty and their prevention by exercise[J]. Free Radic Biol Med,2019,132: 42-49. DOI:10.1016/j.freeradbiomed.2018.08.035. |
[19] | VERSCHOOR C P, JOHNSTONE J, MILLAR J,et al. Alterations to the frequency and function of peripheral blood monocytes and associations with chronic disease in the advanced-age,frail elderly[J]. PLoS One,2014,9(8): e104522. DOI:10.1371/journal.pone.0104522. |
[20] | HSU B, HIRANI V, CUMMING R G,et al. Cross-sectional and longitudinal relationships between inflammatory biomarkers and frailty in community-dwelling older men: the concord health and ageing in men project[J]. J Gerontol A Biol Sci Med Sci,2019,74(6): 835-841. DOI:10.1093/gerona/glx142. |
[21] | ARAÚJO CARVALHO A C, TAVARES MENDES M L, SANTOS V S,et al. Association between human Herpes virus seropositivity and frailty in the elderly: a systematic review and meta-analysis[J]. Ageing Res Rev,2018,48: 145-152. DOI:10.1016/j.arr.2018.10.009. |
[22] | VATIC M, VON HAEHLING S, EBNER N. Inflammatory biomarkers of frailty[J]. Exp Gerontol,2020,133: 110858. DOI:10.1016/j.exger.2020.110858. |
[23] | ALBERRO A, IRIBARREN-LOPEZ A, SÁENZ-CUESTA M,et al. Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency[J]. Sci Rep,2021,11(1): 4358. DOI:10.1038/s41598-021-83991-7. |
[24] | WANG J J, MAXWELL C A, YU F. Biological processes and biomarkers related to frailty in older adults: a state-of-the-science literature review[J]. Biol Res Nurs,2019,21(1): 80-106. DOI:10.1177/1099800418798047. |
[25] | ZAMPINO M, FERRUCCI L, SEMBA R D. Biomarkers in the path from cellular senescence to frailty[J]. Exp Gerontol,2020,129: 110750. DOI:10.1016/j.exger.2019.110750. |
[26] | CLEGG A, HASSAN-SMITH Z. Frailty and the endocrine system[J]. Lancet Diabetes Endocrinol,2018,6(9): 743-752. DOI:10.1016/S2213-8587(18)30110-4. |
[27] | 孙凯旋,吴琳凤,刘永兵,等. 老年衰弱综合征与维生素D的关系[J]. 中国老年学杂志,2019,39(5): 1124-1127. |
[28] | 潘一鸣,马丽娜,李耘. 老年人衰弱综合征相关炎症标记物的研究进展[J]. 实用老年医学,2021,35(4): 427-430. |
[29] | KANG M G, KIM S W, YOON S J,et al. Association between frailty and hypertension prevalence,treatment,and control in the elderly Korean population[J]. Sci Rep,2017,7(1): 7542. DOI:10.1038/s41598-017-07449-5. |
[30] | BERTOLI A, VALENTINI A, CIANFARANI M A,et al. Low FT3: a possible marker of frailty in the elderly[J]. Clin Interv Aging,2017,12: 335-341. DOI:10.2147/CIA.S125934. |
[31] | BANO A, CHAKER L, SCHOUFOUR J,et al. High circulating free thyroxine levels may increase the risk of frailty: the Rotterdam study[J]. J Clin Endocrinol Metab,2018,103(1): 328-335. DOI:10.1210/jc.2017-01854. |
[32] | JIANG S, KANG L, ZHU M L,et al. A potential urinary biomarker to determine frailty status among older adults[J]. Arch Gerontol Geriatr,2020,88: 104038. DOI:10.1016/j.archger.2020.104038. |
[33] | 姜珊. 衰弱的生物标志物:从功能到炎症及氧化应激指标[D]. 北京: 北京协和医学院,2020. |
[34] | NGUYEN A D, MALMSTROM T K, NIEHOFF M L,et al. Serum progranulin levels are associated with frailty in middle-aged individuals[J]. PLoS One,2020,15(9): e0238877. DOI:10.1371/journal.pone.0238877. |
[35] | PÉREZ-ZEPEDA M U, GARCÍA-PEÑA C, CARRILLO-VEGA M F. Individual and cumulative association of commonly used biomarkers on frailty: a cross-sectional analysis of the Mexican Health and Aging Study[J]. Aging Clin Exp Res,2019,31(10): 1429-1434. DOI:10.1007/s40520-019-01127-4. |
[36] | JANG I Y, PARK J H, KIM J H,et al. The association of circulating kynurenine,a tryptophan metabolite,with frailty in older adults[J]. Aging (Albany NY),2020,12(21): 22253-22265. DOI:10.18632/aging.104179. |
[37] | VALENTINI A, CIANFARANI M A, TARANTINO U,et al. Osteoprotegerin as a biomarker of geriatric frailty syndrome[J]. Aging (Albany NY),2019,11(14): 4900-4909. DOI:10.18632/aging.102083. |
[38] | COELHO-JUNIOR H J, PICCA A, CALVANI R,et al. If my muscle could talk: myokines as a biomarker of frailty[J]. Exp Gerontol,2019,127: 110715. DOI:10.1016/j.exger.2019.110715. |
[39] | BORESKIE K F, OLDFIELD C J, HAY J L,et al. Myokines as biomarkers of frailty and cardiovascular disease risk in females[J]. Exp Gerontol,2020,133: 110859. DOI:10.1016/j.exger.2020.110859. |
[40] | 彭和香,高文静,曹卫华,等. DNA甲基化年龄研究进展[J]. 预防医学情报杂志,2020,36(7): 896-902. |
[41] | HE X, LIU J J, LIU B,et al. The use of DNA methylation clock in aging research[J]. Exp Biol Med (Maywood),2021,246(4): 436-446. DOI:10.1177/1535370220968802. |
[42] | MUTHUPPALANIAPPAN V, MCCAFFERTY K, YAQOOB M. p0070are biomarkers of ageing in the form of telomere length and/or the DNA methylation status associated with frailty phenotype in patients with end stage kidney disease on dialysis?[J]. Nephrol Dial Transplant,2020,35(): gfaa142.P0070. DOI:10.1093/ndt/gfaa142.P0070. |
[43] | VETTER V M, SPIRA D, BANSZERUS V L,et al. Epigenetic clock and leukocyte telomere length are associated with vitamin D status but not with functional assessments and frailty in the berlin aging study II[J]. J Gerontol A Biol Sci Med Sci,2020,75(11): 2056-2063. DOI:10.1093/gerona/glaa101. |
[44] | RUSANOVA I, FERNÁNDEZ-MARTÍNEZ J, FERNÁNDEZ-ORTIZ M,et al. Involvement of plasma miRNAs,muscle miRNAs and mitochondrial miRNAs in the pathophysiology of frailty[J]. Exp Gerontol,2019,124: 110637. DOI:10.1016/j.exger.2019.110637. |
[45] | KAMEDA M, TERUYA T, YANAGIDA M,et al. Frailty markers comprise blood metabolites involved in antioxidation,cognition,and mobility[J]. PNAS,2020,117(17): 9483-9489. DOI:10.1073/pnas.1920795117. |
[46] | DENT E, HOOGENDIJK E O, MOLDOVAN M. Frailty index from routine laboratory measurements correlates with leukocyte telomere length[J]. Geriatr Gerontol Int,2018,18(4): 654-655. DOI:10.1111/ggi.13257. |
[47] | 刘欣艺,乔晓霞,金雅茹,等. 营养不良在社区老年人抑郁和衰弱之间的中介作用[J].中国老年学杂志,2019,39(18):4592-4595. DOI:10.3969/j.issn.1005-9202.2019.18.068. |
[48] | POLAT Y, YALCIN A, YAZIHAN N,et al. The relationship between frailty and serum alpha klotho levels in geriatric patients[J]. Arch Gerontol Geriatr,2020,91:104225. DOI:10.1016/j.archger.2020.104225. |
[49] | HONG X F, YAN J, XU L Y,et al. Relationship between nutritional status and frailty in hospitalized older patients[J]. Clin Interv Aging,2019,14: 105-111. DOI:10.2147/CIA.S189040. |
[50] | EL ASSAR M, ANGULO J, CARNICERO J A,et al. Frailty is associated with lower expression of genes involved in cellular response to stress: results from the Toledo study for healthy aging[J]. J Am Med Dir Assoc,2017,18(8): 734.e1-734.e7. DOI:10.1016/j.jamda.2017.04.019. |
[51] | NG T K S, KOVALIK J P, CHING J,et al. Novel metabolomics markers are associated with pre-clinical decline in hand grip strength in community-dwelling older adults[J]. Mech Ageing Dev,2021,193: 111405. DOI:10.1016/j.mad.2020.111405. |
[52] | 薛梦婷,姜荣荣,徐桂华,等. 老年人衰弱的研究进展[J]. 中国老年学杂志,2021,41(8): 1761-1765. |
[53] | FURTADO G E, CARVALHO H M, LOUREIRO M,et al. Chair-based exercise programs in institutionalized older women: Salivary steroid hormones,disabilities and frailty changes[J]. Exp Gerontol,2020,130: 110790. DOI:10.1016/j.exger.2019.110790. |
[54] | YIN M J, XIONG Y Z, XU X J,et al. Tfh cell subset biomarkers and inflammatory markers are associated with frailty status and frailty subtypes in the community-dwelling older population: a cross-sectional study[J]. Aging (Albany NY),2020,12(3): 2952-2973. DOI:10.18632/aging.102789. |
[55] | LAURETANI F, SEMBA R D, BANDINELLI S,et al. Association of low plasma selenium concentrations with poor muscle strength in older community-dwelling adults: the InCHIANTI Study[J]. Am J Clin Nutr,2007,86(2): 347-352. DOI:10.1093/ajcn/86.2.347. |
[56] | BRONAS U G, PUZANTIAN H, HANNAN M. Cognitive impairment in chronic kidney disease: vascular milieu and the potential therapeutic role of exercise[J]. Biomed Res Int,2017,2017: 2726369. DOI:10.1155/2017/2726369. |
[57] | SANCHIS J, NÚÑEZ E, RUIZ V,et al. Usefulness of clinical data and biomarkers for the identification of frailty after acute coronary syndromes[J]. Can J Cardiol,2015,31(12): 1462-1468. DOI:10.1016/j.cjca.2015.07.737. |
[58] | 张仲迎,高歌,李莹,等. 同型半胱氨酸与老年衰弱综合征的研究进展[J]. 北京医学,2020,42(5): 439-443. DOI:10.15932/j.0253-9713.2020.05.022. |
[59] | 王丽娜,姜春燕,李虹伟. 老年衰弱合并急性冠脉综合征的研究进展[J]. 中国全科医学,2020,23(19): 2467-2471.DOI:10.12114/j.issn.1007-9572.2020.00.079. |
[60] | 张方芳,雷向仰,章可霞,等. 心脏超声联合血清N末端脑钠肽前体水平对慢性心力衰竭的诊断价值[J]. 实用心脑肺血管病杂志,2021,29(2):130-132. DOI:10.12114/j.issn.1008-5971.2021.00.018. |
[61] | BESSEMS S A M, KONSTEN J L M, VOGELAAR J F J,et al. Frailty screening by Geriatric-8 and 4-meter gait speed test is feasible and predicts postoperative complications in elderly colorectal cancer patients[J]. J Geriatr Oncol,2021,12(4): 592-598. DOI:10.1016/j.jgo.2020.10.012. |
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