中国全科医学 ›› 2022, Vol. 25 ›› Issue (08): 1021-1026.DOI: 10.12114/j.issn.1007-9572.2021.01.045
所属专题: 儿科最新文章合集
• 前沿进展 • 上一篇
崔天怡1,2, 刘佳蕊1,2, 吕彬1,2, 高秀梅1,2, 赵鑫1,2,*
收稿日期:
2021-09-11
修回日期:
2021-11-25
出版日期:
2022-03-15
发布日期:
2022-03-02
通讯作者:
赵鑫
基金资助:
Novel Developments in the Relationship of Gut Microbiota and Immune Regulation with Childhood Asthma
CUI Tianyi1,2,LIU Jiarui1,2,LYU Bin1,2,GAO Xiumei1,2,ZHAO Xin1,2*
1. Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China
2. Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China
*Corresponding author:ZHAO Xin,Assistant professor;E-mail:xinaw26@tju.edu.cn
Received:
2021-09-11
Revised:
2021-11-25
Published:
2022-03-15
Online:
2022-03-02
摘要: 支气管哮喘(以下简称哮喘)是一种常见的慢性呼吸系统疾病,严重威胁人类健康。迄今为止,全球约有3亿多人患有哮喘,其中儿童居多。流行病学调查研究显示,我国0~14岁儿童哮喘患病率为2.32%,且呈明显上升趋势。对于儿童而言,免疫系统发育不全且肠道菌群正处于生理性演替过程,极容易发生肠道菌群失调,导致肠黏膜屏障的破坏以及局部免疫失调,进而严重影响儿童哮喘的发生发展。本文将论述儿童哮喘发生、发展的免疫调节作用机制与肠道微生物的关系,并基于肠道菌群探讨干预措施,为哮喘的治疗提供新思路。
中图分类号:
CUI Tianyi, LIU Jiarui, LYU Bin, GAO Xiumei, ZHAO Xin.
Novel Developments in the Relationship of Gut Microbiota and Immune Regulation with Childhood Asthma [J]. Chinese General Practice, 2022, 25(08): 1021-1026.
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