关键词: 糖尿病, 2型；肥胖症；心肺耐力；心肺运动试验

Abstract: Background　Cardiorespiratory fitness（CRF） is closely related to the incidence rate and mortality of type 2 diabetes mellitus （T2DM）. Overweight and obesity are prevalent in a large proportion of patients with T2DM，but it is not clear whether they deteriorate the damage of CRF. Objective　To investigate the characteristics of CRF and its association with overweight and obesity in patients with T2DM. Methods　We enrolled 87 T2DM inpatients and outpatients from Department of Endocrinology，Beijing Boai Hospital，China Rehabilitation Research Center from December 2018 to December 2019. They all completed symptom-limited cardiopulmonary exercise testing（CPET），and parameters such as peakVO2，peakVO2/kg，resting VO2，peak-METs，peakVO2%P，and Peak-WR were compared among normal weight group（n=22），overweight group（n=27）and obesity group （n=38）stratified by BMI to evaluate the association of BMI with CRF parameters. Results　We noted that the level of peakVO2/kg in 59 patients （67.8%） was lower than 20 ml•kg-1•min-1，and the peakVO2%P in 70 patients （80.5%） was lower than 84%. There were significant differences in the peakVO2，peakVO2/kg，resting VO2，and peak-METs among the three groups （P<0.01）. The resting VO2 of overweight group was higher than that of normal weight group（P<0.05）. The peakVO2 of obesity group was higher than that of normal weight group（P<0.05）. The obesity group had lower peakVO2/kg and peak-METs and higher resting VO2 than other two groups（P<0.05）. There were no significant differences in Peak-WR and peakVO2%P across the groups（P>0.05）. Pearson correlation analysis showed BMI was positively correlated with peakVO2，resting VO2，and Peak-WR（r=0.525，0.405，0.222，P<0.05），and was negatively correlated with peakVO2/kg，and peakMETs（r=-0.402，-0.402，P<0.01）. Conclusion　It is suggested that the CRF in most T2DM decreased and the impaired CRF is further aggravated by obesity.

Key words: Diabetes mellitus, type 2；Obesity；Cardiorespiratory fitness；Cardiopulmonary exercise testing