关键词: 糖尿病, 2型, 糖尿病神经病变, 痛性糖尿病神经病变, 糖尿病并发症, 影响因素分析

Abstract: Background　As a common complication of type 2 diabetes mellitus （T2DM），painful diabetic neuropathy（PDN） is often overlooked or misdiagnosed，particularly in physicians with lack of sufficient understanding of related risk factors，which may delay appropriate treatment.Objective　To explore the influencing factors of PDN in T2DM，providing countermeasures for early clinical intervention and active prevention of this disease.Methods　273 eligible T2DM patients who were hospitalized in Department of Endocrinology，Anqing Municipal Hospital were enrolled from January 2016 to December 2019，including 88 with PDN（PDN group），and 185 without（NPDN group）.The demographic information and laboratory test results were compared between the two groups.Multivariate unconditional Logistic regression analysis was used to explore the influencing factors of PDN.Results　PDN group showed greater average age，BMI，FPG，2 hPG，HbA1c，and longer average course of T2DM，higher prevalence of diabetic retinopathy and diabetic kidney disease，as well as lower average 1-hour and 2-hour postprandial C-peptide levels（P<0.05）.Multivariate unconditional Logistic regression analysis showed that the course of T2DM 〔OR=1.079，95%CI（1.003，1.160）〕，diabetic retinopathy〔OR=7.524，95%CI（1.363，41.541）〕，diabetic kidney disease〔OR=3.547，95%CI（1.134，11.095）〕，FPG 〔OR=1.831，95%CI（1.384，2.422）〕，and HbA1c〔OR=2.468，95%CI（1.694，3.596）〕were associated with PDN in T2DM （P<0.05）.Conclusion　The course of T2DM，diabetic retinopathy，diabetic kidney disease，FPG and HbA1c may be influencing factors of PDN in T2DM.Clinical attention should be paid to these factors in T2DM patients to early prevent PDN or deliver interventions.

Key words: Diabetes mellitus, type 2；Diabetic neuropathies；Painful diabetic neuropathy；Diabetes complications；Root cause analysis