关键词: 胃底腺息肉, 胃息肉, 胃镜, 幽门螺杆菌, 质子泵抑制剂

Abstract: Objective　To investigate the epidemiological，and endoscopic features as well as pathogenesis-related factors of fundic gland polyps（FGPs）．Methods　This study was carried out following a retrospective design.Participants were recruited from Gastroscopy Center，Huadong Hospital Affiliated to Fudan University during October 2014 to June 2016.All of them were initially found with gastric polyps by gastroscopy，and were diagnosed with FGPs by pathologic results of biopsies or resection specimens.Clinical，endoscopic and pathological data were collected.Some of the patients were selected by a random number table，and were given a telephone follow-up.Treatment with proton pump inhibitors （PPIs） was surveyed via the telephone，including the name and dose of the PPI，as well as the course of treatment （≤3 months，4-6 months，7-12 months，>12 months）．Results　Altogether，1 909 of the 29 309 cases undergoing gastroscopy were found with gastric polyp，including 1 200 cases of FGPs，the prevalence of FGPs was 4.09%（1 200/29 309）．In FGPs cases，male-to-female ratio was 1∶1.91.FGPs mainly grew in the stomach body 〔692 cases （57.7%） 〕 and fundus 〔464 cases （38.6%）〕 with diameters ranging from 1 to 5 mm 〔1 082 cases （90.1%）〕.Single FGP was found in 797 cases （66.4%），and multiple FGPs were found in 403 cases （33.6%）．The prevalence of FGPs with reflux esophagitis，FGPs with active gastroduodenal ulcer，FGPs with bile reflux，FGPs with intestinal metaplasia in gastric antral mucosa，and FGPs with atrophy in the antral mucosa was 15.2%（183 cases），5.6%（67 cases），4.1%（49 cases），19.3%（232 cases），and 14.8%（178 cases），respectively.A total of 322 cases received the telephone follow-up，among whom 179 （55.6%） received PPIs treatment，and the duration of PPIs treatment was ≤3 months for 97 cases （54.2%），4-6 months for 31 cases （17.3%），7-12 months for 28 cases （15.7%），and longer than 12 months for 23 cases （12.8%）．61 cases（34.1%） were treated with omeprazole，85（47.5%） with rabeprazole，20（11.2%） with pantoprazole，4（2.2%） with lansoprazole，and 9（5.0%） with esomeprazole.The type of PPIs used in the patients differed significantly by the duration of PPIs treatment （χ2=35.083，P<0.05） as well as age group （χ2=31.829，P<0.05）．Conclusion　FGPs are common intragastinal lesions，which are more common in women clinically.Most FGPs occur in the fundus and the body of the stomach，mainly single，with a diameter of 1-5 mm.Endoscopic examination shows that FGPs are often associated with reflux esophagitis，peptic ulcer，bile reflux，etc.For FGPs patients applying PPIs，the choice of PPIs should be determined by the patient's age and duration of treatment.

Key words: Fundic gland polyp, Gastric polyps, Upper endoscopy, Helicobacter pylori, Proton pump inhibitors