关键词: 甲状腺肿瘤, 病理学, 性别分布, 年龄分布, 人口统计学

Abstract: Objective　To examine the status and changes of clinicopathological characteristics of thyroid cancer patients with surgical treatment in Peking University Cancer Hospital between 1996 and 2015，providing support for the prevention and treatment of this kind of disease.Methods　The data stemmed from the electronic medical record statistics system of Peking University Cancer Hospital，involving a sample of eligible 3 703 thyroid cancer patients receiving surgical treatment between 1996 and 2015.Descriptive analyses of the data were performed by sex，age，type of thyroid cancer，status of lymphatic metastasis，concomitant diseases，and geographical settings（urban-rural location and regions defined mainly according to the socioeconomic status）.Results　During this period，the annual number of patients undergoing thyroid cancer surgery showed an increasing trend（P<0.05）.Moreover，both male and female patients increased across the period generally（P<0.05）.However，the male-to-female ratio changed a little during the period（P>0.05）.Furthermore，the year-over-year increase rate did not differ significantly by sex（P>0.05）.The number of patients undergoing thyroid cancer surgery increased significantly from the age of 25，peaked at 35 to 54（56.37%），and gradually declined after 55.The male-to-female ratio varied significantly by age group（P<0.05）.The distribution of age group in all participants differed significantly by year（P<0.05），but the average age did not（P>0.05）.Furthermore，the average age of both male and female participants did not varied notably by year（P>0.05）.In terms of type of thyroid cancer，papillary thyroid cancer patients and their occupied proportion of the total participants increased over the period（P<0.05）.Females were more likely to have papillary thyroid cancer compared with males（P<0.05）.With regard to lymphatic metastasis，patients with medullary thyroid cancer had higher rate of lymphatic metastasis than those with papillary thyroid cancer or follicular thyroid cancer（P<0.05）.Compared with males，female papillary thyroid cancer patients demonstrated lower rate of lymphatic metastasis but higher rate of accompanying nodular goiter（P<0.05）.The proportion of rural patients showed an increasing trend（P<0.05），but the distribution of patients by region did not change significantly（P>0.05）.Conclusion　The number of thyroid cancer patients receiving surgical treatment is increasing year by year，coexisting gender and age differences.The main pathological type is papillary carcinoma，and many patients have lymph node metastasis or nodular goiter.Most of them are from north China，in particular，urban patients outnumber rural patients.

Key words: Thyroid neoplasms, Pathology, Sex distribution, Age distribution, Demography