Page 95 - 2022-23-中国全科医学
P. 95

·2908· http://www.chinagp.net   E-mail:zgqkyx@chinagp.net.cn


               5374.285005.                                         Acta Neuropathol，2018，135（3）：311-336. DOI：10.1007/
           ［14］SHEN J，LI Y Q，QU C J，et al. The enriched environment   s00401-018-1815-1.
               ameliorates chronic unpredictable mild stress-induced depressive-  ［25］NATION D A，SWEENEY M D，MONTAGNE A，et al. Blood-
               like  behaviors  and  cognitive  impairment  by  activating  the   brain barrier breakdown is an early biomarker of human cognitive
               SIRT1/miR-134 signaling pathway in Hippocampus［J］. J Affect   dysfunction［J］. Nat Med，2019，25（2）：270-276. DOI：
               Disord，2019，248：81-90. DOI：10.1016/j.jad.2019.01.031.  10.1038/s41591-018-0297-y.
           ［15］QIAN Y，SONG J L，OUYANG Y M，et al. Advances in roles of   ［26］QU C H，XU L L，SHEN J，et al. Protection of blood-brain
               miR-132 in the nervous system［J］. Front Pharmacol，2017，8：  barrier as a potential mechanism for enriched environments
               770. DOI：10.3389/fphar.2017.00770.                   to improve cognitive impairment caused by chronic cerebral
           ［16］HANSEN K F，SAKAMOTO K，ATEN S，et al. Targeted deletion   hypoperfusion［J］. Behav Brain Res，2020，379：112385.
               of miR-132 /-212 impairs memory and alters the hippocampal   DOI：10.1016/j.bbr.2019.112385.
               transcriptome［J］. Learn Mem，2016，23（2）：61-71. DOI：  ［27］QU C H，SONG H，SHEN J，et al. Mfsd2a reverses spatial
               10.1101/lm.039578.115.                               learning and memory impairment caused by chronic cerebral
                                                                    hypoperfusion via protection of the blood–brain barrier［J］. Front
           ［17］WEI Z Y，MENG X J，EL FATIMY R，et al. Environmental
                                                                    Neurosci，2020，14：461. DOI：10.3389/fnins.2020.00461.
               enrichment prevents Aβ oligomer-induced synaptic dysfunction
                                                               ［28］ZHAN Y，LI M Z，YANG L，et al. The three-phase enriched
               through mirna-132 and hdac3 signaling pathways［J］. Neurobiol
                                                                    environment paradigm promotes neurovascular restorative and
               Dis，2020，134：104617. DOI：10.1016/j.nbd.2019.104617.
                                                                    prevents learning impairment after ischemic stroke in rats［J］.
           ［18］KUBOTA K，NAKANO M，KOBAYASHI E，et al. An enriched
                                                                    Neurobiol  Dis，2020，146：105091.  DOI：10.1016/j.
               environment prevents diabetes-induced cognitive impairment in rats
                                                                    nbd.2020.105091.
               by enhancing exosomal miR-146a secretion from endogenous bone
                                                               ［29］MA Q，REITER R J，CHEN Y D. Role of melatonin in controlling
               marrow-derived mesenchymal stem cells［J］. PLoS One，2018，
                                                                    angiogenesis under physiological and pathological conditions［J］.
               13（9）：e0204252. DOI：10.1371/journal.pone.0204252.
                                                                    Angiogenesis，2020，23（2）：91-104. DOI：10.1007/s10456-
           ［19］ERGEN F B，COSAN D T，KANDEMIR T，et al. An enriched
                                                                    019-09689-7.
               environment leads to increased synaptic plasticity-associated miRNA
                                                               ［30］GUO D X，ZHU Z B，ZHONG C K，et al. Increased serum
               levels after experimental subarachnoid hemorrhage［J］. J Stroke
                                                                    netrin-1 is associated with improved prognosis of ischemic
               Cerebrovasc Dis，2021，30（6）：105766. DOI：10.1016/j.jstro
                                                                    stroke［J］.  Stroke，2019，50（4）：845-852.  DOI：
               kecerebrovasdis.2021.105766.
                                                                    10.1161/STROKEAHA.118.024631.
           ［20］SIES H，JONES D P. Reactive oxygen species （ROS） as
                                                               ［31］RUST R，GRÖNNERT L，WEBER R Z，et al. Refueling the
               pleiotropic physiological signalling agents［J］. Nat Rev Mol Cell
                                                                    ischemic CNS：guidance molecules for vascular repair［J］.
               Biol，2020，21（7）：363-383. DOI：10.1038/s41580-020-
                                                                    Trends Neurosci，2019，42（9）：644-656. DOI：10.1016/j.
               0230-3.
                                                                    tins.2019.05.006.
           ［21］NORMANN M C，MCNEAL N，DAGNER A，et al. The influence
                                                               ［32］XIE Q F，CHENG J Y，PAN G Y，et al. Treadmill exercise
               of environmental enrichment on cardiovascular and behavioral
                                                                    ameliorates  focal  cerebral  ischemia/reperfusion-induced
               responses to social stress［J］. Psychosom Med，2018，80（3）：
                                                                    neurological deficit by promoting dendritic modification and
               271-277. DOI：10.1097/PSY.0000000000000558.
                                                                    synaptic plasticity via upregulating caveolin-1/VEGF signaling
           ［22］ZHANG  X  X，YUAN  M，YANG  S  B，et  al.  Enriched
                                                                    pathways［J］. Exp Neurol，2019，313：60-78. DOI：10.1016/j.
               environment improves post-stroke cognitive impairment and inhibits
                                                                    expneurol.2018.12.005.
               neuroinflammation and oxidative stress by activating Nrf2-ARE
                                                               ［33］HAYASHI  Y，JINNOU  H，SAWAMOTO  K，et  al.  Adult
               pathway［J］. Int J Neurosci，2021，131（7）：641-649. DOI：  neurogenesis  and  its  role  in  brain  injury  and  psychiatric
               10.1080/00207454.2020.1797722.                       diseases［J］. J Neurochem，2018，147（5）：584-594. DOI：
           ［23］牛磊，罗诗诗，李威，等 .  丰富环境通过抑制 NOD 样受体                      10.1111/jnc.14557.
               蛋白 3 炎性小体活化缓解脂多糖小鼠的认知障碍［J］. 解剖                  ［34］LU J，XU S W，HUO Y Q，et al. Sorting nexin 3 induces heart
               学   报，2020，51（2）：172-177. DOI：10.16098/j.issn.0529-  failure via promoting retromer-dependent nuclear trafficking of
               1356.2020.02.004.                                    STAT3［J］. Cell Death Differ，2021，28（10）：2871-2887.
               NIU L，LUO S S，LI W，et al. Environmental enrichment   DOI：10.1038/s41418-021-00789-w.
               ameliorates lipopolysaccharide-induced cognitive impairment by   ［35］WU X Y，LIU S Q，HU Z H，et al. Enriched housing promotes
               inhibiting NOD-like recepter protein 3 in fla mmasome activation in   post-stroke neurogenesis through calpain 1-STAT3/HIF-1α/VEGF
               mice［J］. Acta Anatomica Sinica，2020，51（2）：172-177.   signaling［J］. Brain Res Bull，2018，139：133-143. DOI：
               DOI：10.16098/j.issn.0529-1356.2020.02.004.           10.1016/j.brainresbull.2018.02.018.
           ［24］LIEBNER S，DIJKHUIZEN R M，REISS Y，et al. Functional   ［36］OLDE ENGBERINK A，HERNANDEZ R，DE GRAAN P，et al.
               morphology of the blood-brain barrier in health and disease［J］.   Rapamycin-sensitive late-LTP is enhanced in the Hippocampus of
   90   91   92   93   94   95   96   97   98   99   100