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                                                                                                 ·论著·


           西藏地区消化性溃疡出血的临床特征研究



               1
           许颖 ,次仁央金        2*                                                                扫描二维码
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               【摘要】 背景 西藏地处高原,消化性溃疡出血高发,但目前对西藏地区消化性溃疡出血的临床特点以及溃疡
           出血与再出血的危险因素报道较少见。目的 探讨西藏地区消化性溃疡出血的临床特点,以及高危溃疡出血及再出血
           可能的危险因素。方法 选取 2017—2020 年在西藏自治区人民医院因上消化道出血就诊,且经胃镜检查明确诊断为
           消化性溃疡出血的住院患者 212 例。根据胃镜下病变 Forrest 分级将患者分为高危组(Ⅰ a~ Ⅱ b 级)和低危组(Ⅱ c
           级和Ⅲ级)。高危组患者根据是否发生再出血分为再出血亚组和无再出血亚组。分析患者的一般资料和临床特点,并
           采用多因素 Logistic 回归分析探究消化性溃疡出血高危情况的影响因素。结果 212 例患者中,男女比例为 5.42∶1;
           胃溃疡出血 125 例(59.0%),十二指肠溃疡出血 87 例(41.0%);高危组 86 例(40.6%),低危组 126 例(59.4%);
           再出血亚组 12 例(14.0%),无再出血亚组 74 例(86.0%)。高危组血红蛋白(HGB)、尿素氮(BUN)、再出血发
           生率、住院天数高于低危组(P<0.05)。多因素 Logistic 回归分析结果显示,HGB〔OR=1.007,95%CI(1.001,1.014),
           P=0.028〕和 BUN〔OR=1.061,95%CI(1.003,1.121),P=0.037〕是消化性溃疡出血高危的独立影响因素。再出血亚
           组血小板计数(PLT)、白蛋白(ALB)水平低于无再出血亚组(P<0.05)。结论 西藏地区消化性溃疡出血患者中,
           男性多于女性,胃溃疡多于十二指肠溃疡。入院时 HGB、BUN 水平是高危消化性溃疡出血的独立影响因素。入院时
           PLT、ALB 水平可能是高危消化性溃疡再出血的影响因素。
               【关键词】 消化性溃疡出血;危险因素;疾病特征;西藏[自治区];高原
               【中图分类号】 R 573.2 【文献标识码】 A DOI:10.12114/j.issn.1007-9572.2021.02.059
               许颖,次仁央金 .  西藏地区消化性溃疡出血的临床特征研究[J].  中国全科医学,2022,25(6):724-
           728.[www.chinagp.net]
               XU Y,Cirenyangjin. Clinical analysis of peptic ulcer bleeding in Tibet[J]. Chinese General Practice,2022,25(6):
           724-728.

                                                         1
           Clinical Analysis of Peptic Ulcer Bleeding in Tibet XU Ying ,Cirenyangjin 2*
           1.Department of Gastroenterology,Peking University First Hospital,Beijing 100034,China
           2.Department of Gastroenterology,Tibet Autonomous Region People's Hospital,Lhasa 850000,China
           *
           Corresponding author:Cirenyangjin,Associate chief physician;E-mail:cirenyangjin6666@163.com
               【Abstract】 Background Tibet is located on the plateau with a high incidence of peptic ulcer bleeding,but there
           are few reports about the clinical characteristics of peptic ulcer bleeding,as well as the risk factors of bleeding and rebleeding
           associated with peptic ulcer in Tibet. Objective To explore the clinical characteristics of peptic ulcer bleeding,and the potential
           risk factors of bleeding and rebleeding associated with high-risk peptic ulcer in Tibet. Methods A total of 212 hospitalized
           patients who visited the Tibet Autonomous Region People's Hospital for upper gastrointestinal bleeding and were clearly diagnosed
           as peptic ulcer bleeding by gastroscopy from 2017 to 2020 were selected. Patients were divided into two groups according to the
           Forrest classification under endoscopy: high-risk group (Ⅰ a- Ⅱ b) and low-risk group (Ⅱ c and Ⅲ). The high-risk group
           was further divided into rebleeding subgroup and non-rebleeding subgroup according to the occurrence of rebleeding. The general
           data and clinical characteristics of the patients were analyzed,and multivariate Logistic regression analysis was used to explore the
           influencing factors of the high risk of peptic ulcer bleeding. Results Among 212 patients with peptic ulcer bleeding,the male-
           to-female ratio was 5.42∶1;including 125 cases (59.0%) with gastric ulcer bleeding,87 cases (41.0%) with duodenal
           ulcer bleeding;86(40.6%) patients in the high-risk group,and 126(59.4%) in the low-risk group. There were 12(14.0%)
           patients in the rebleeding subgroup,and 74(86.0%)in the non-rebleeding subgroup. The hemoglobin level(HGB),urea
           nitrogen (BUN),the rebleeding rate and the length of hospital stay in high-risk group were higher than low-risk group (P<0.05).
           Multivariate Logistic regression analysis showed that HGB〔OR=1.007,95%CI(1.001,1.014),P=0.028〕 and BUN〔OR=1.061,


               1.100034 北京市,北京大学第一医院消化内科 2.850000 西藏自治区拉萨市,西藏自治区人民医院消化内科
               *
               通信作者:次仁央金,副主任医师;E-mail:cirenyangjin6666@163.com
               本文数字出版日期:2021-09-30
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