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           多囊卵巢综合征患者听损伤特点及影响因素研究



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           解志佳 ,张蕾 ,陈昕 ,常涛              3                                                    扫描二维码
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               【摘要】 背景 已有研究证实多囊卵巢综合征(PCOS)患者存在听损伤,但关于 PCOS 患者听损伤的影响因素
           未得到充分阐释。目的 探究 PCOS 患者听损伤特点并分析其影响因素。方法 选取2018年3月至2021年2月苏州
           市第九人民医院妇科确诊的 PCOS 患者 203 例(406 耳)为 PCOS 组,选取同期本院 30 例体检健康女性(60 耳)为对
           照组。比较两组的听力学检查结果。采用多因素 Logistic 回归分析探讨 PCOS 患者听损伤影响因素。结果 PCOS 组中
           低频(0.25~2.00 kHz)听阈值与对照组比较,差异无统计学意义(P>0.05);PCOS 组高频(4.00 kHz、8.00 kHz)和
           扩展高频(10.00~20.00 kHz)听阈值均高于对照组(P<0.05)。203 例 PCOS 患者听阈测试中听损伤者占 25.62%(52/203)。
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           PCOS 患者病程越长,其听损伤发生率越高、损伤程度越重(χ 趋势 =42.475,P<0.001)。PCOS 患者中伴有听损伤患
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           者胰岛素抵抗发生率低于非听损伤患者(χ =12.765,P<0.001);伴有听损伤 PCOS 患者的 C 反应蛋白(CRP)、
           同型半胱氨酸(Hcy)、空腹血糖(FBG)、三酰甘油(TG)均高于非听损伤患者(t=2.490、2.819、2.419、4.436,
           P<0.05)。多因素 Logistic 回归分析显示,病程和胰岛素抵抗、CRP、Hcy、FBG、TG 是 PCOS 患者听损伤的影响因素
           (P<0.001)。结论 PCOS 患者的病程和胰岛素抵抗、CRP 升高、高血糖、Hcy 高表达、血脂异常是 PCOS 患者听损
           伤的影响因素,临床应根据各诱因采取措施来防止或延缓 PCOS 患者听损伤的发生与发展。
               【关键词】 多囊卵巢综合征;听力损失;胰岛素抵抗;血糖;影响因素分析
               【中图分类号】 R 711.75 【文献标识码】 A DOI:10.12114/j.issn.1007-9572.2021.02.047
               解志佳,张蕾,陈昕,等 . 多囊卵巢综合征患者听损伤特点及影响因素研究[J]. 中国全科医学,2022,25(3):
           341-345.[www.chinagp.net]
               XIE Z J,ZHANG L,CHEN X,et al. Analysis of characteristics and influencing factors of hearing impairment in patients
           with polycystic ovary syndrome[J]. Chinese General Practice,2022,25(3):341-345.

           Analysis of Characteristics and Influencing Factors of Hearing Impairment in Patients with Polycystic Ovary Syndrome
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            XIE Zhijia ,ZHANG Lei ,CHEN Xin ,CHANG Tao 3
           1.Department of Gynecology,Suzhou Ninth People's Hospital,Suzhou 215200,China
           2.Department of Gynecology,the Second Affiliated Hospital of Soochow University,Suzhou 215200,China
           3.Department of Otorhinolaryngology,Suzhou Ninth People's Hospital,Suzhou 215200,China
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           Corresponding author:ZHANG Lei,Associate chief physician;E-mail:329450851@qq.com
               【Abstract】 Background Hearing impairment in patients with polycystic ovary syndrome (PCOS) has been
           confirmed,However,the influencing factors of hearing impairment in PCOS patients have not been fully explained. Objective
            To explore the characteristics of hearing impairment in patients with PCOS and analyze its influencing factors. Methods 203
           PCOS patients(406 ears) diagnosed in the Department of Gynecology,Suzhou Ninth People's Hospital from March 2018 to
           February 2021 were selected as the PCOS group. At the same time,30 healthy women(60 ears) were selected as the control
           group. The audiology examination results of the two groups were compared. Logistic regression analysis was used to explore the
           influencing factors of hearing impairment in PCOS patients. Results Compared with the control group,there was no statistically
           significant difference in the hearing threshold of PCOS patients with low and medium frequencies(0.25-2.00 kHz)(P>0.05).
           The hearing thresholds of high frequency(4.00 kHz,8.00 kHz) and extended high frequency(10.00-20.00 kHz) in the
           PCOS group were higher than those in the control group(P<0.05). Auditory impairment accounted for 25.62%(52/203) in
           the auditory valve test of 203 PCOS patients. The longer the course of PCOS,the higher the incidence and severity of hearing
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           impairment(χ  trend =42.475,P<0.001). The incidence of insulin resistance in PCOS patients with hearing impairment was
               基金项目:苏州市科技计划项目(230301)
               1.215200 江苏省苏州市第九人民医院妇科 2.215200 江苏省苏州市,苏州大学附属第二医院妇科 3.215200 江苏省苏州市第九
           人民医院耳鼻咽喉科
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               通信作者:张蕾,副主任医师;E-mail:329450851@qq.com
               本文数字出版日期:2021-09-03
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