The prevalence of overweight and obesity has been increasing yearly and become a global public health problem with a range of consequences causing widespread concern. Weight loss can reduce the incidence of type 2 diabetes, cardiovascular risk, and all-cause mortality. The most common approaches of weight loss are drug therapy, surgery and lifestyle interventions including diet and exercise, however, exercise intervention remains the healthiest and most fundamental approach of weight loss. Exercise can reduce cellulite, increase muscle mass and improve metabolism. The combination of exercise and other weight loss approaches can reduce adverse reactions and produce better results. Continuing exercise after weight loss can also effectively prevent rebound and maintain weight loss effects. This paper reviews the definition, mechanism, effect, and management of "exercise is the foundation of weight loss", and provide a reference for weight loss through exercise in the context of the experience of Zhongda Hospital.

超重和肥胖的患病率逐年攀增，已成为危害全球的公共卫生问题，造成的一系列后果也引起了人们广泛关注。减重可以降低2型糖尿病、心血管疾病的发病率和全因死亡率。目前常见的减重方式有药物、手术及包括饮食、运动在内的生活方式干预，但运动干预仍然是最为健康且最为基础的减重方式。运动可减少脂肪，增加肌肉含量，改善代谢。当运动与其余减重方式相结合，可减少减重的不良反应，效果更好。在减重过后进行持续运动，还可以有效阻止反弹，保持减重效果。本文从"运动是减重之本"的定义、机制、效应和管理四个层面探索，并结合"中大医院经验"为运动减重提供参考。