Chinese General Practice ›› 2023, Vol. 26 ›› Issue (26): 3290-3296.DOI: 10.12114/j.issn.1007-9572.2022.0899
• Original Research • Previous Articles Next Articles
Received:
2022-12-22
Revised:
2023-03-01
Published:
2023-09-15
Online:
2023-03-28
Contact:
LI Xin
通讯作者:
李新
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0899
组别 | 例数 | 性别(男/女) | 年龄( | 吸烟史〔例(%)〕 | 饮酒史〔例(%)〕 | 高血压〔例(%)〕 | 糖尿病〔例(%)〕 | 冠心病〔例(%)〕 |
---|---|---|---|---|---|---|---|---|
AKI组 | 150 | 81/69 | 73.6±12.6 | 69(46.00) | 25(16.67) | 114(76.00) | 46(30.67) | 40(26.67) |
非AKI组 | 1 052 | 664/388 | 70.7±11.5 | 430(40.87) | 263(25.00) | 760(72.24) | 354(33.65) | 281(26.71) |
检验统计量值 | 4.632 | 2.849a | 1.420 | 5.004 | 0.934 | 0.526 | 0 | |
P值 | 0.031 | 0.004 | 0.233 | 0.025 | 0.334 | 0.468 | 0.991 | |
组别 | 有脑卒中病史〔例(%)〕 | 心房颤动〔例(%)〕 | 脑卒中类型〔例(%)〕 | 入院时NIHSS评分〔M(P25,P75),分〕 | ||||
LAA | SAA | CE | SOE | SUE | ||||
AKI组 | 57(38.00) | 24(16.00) | 55(36.67) | 46(30.67) | 32(21.33) | 1(0.67) | 16(10.67) | 9(4,17) |
非AKI组 | 345(32.79) | 124(11.79) | 359(34.13) | 471(44.77) | 116(11.03) | 13(1.24) | 93(8.84) | 4(2,8) |
检验统计量值 | 1.598 | 2.158 | 18.493 | 7.793b | ||||
P值 | 0.206 | 0.142 | 0.001 | <0.001 |
Table 1 Comparison of demographic data between AKI group and non-AKI group
组别 | 例数 | 性别(男/女) | 年龄( | 吸烟史〔例(%)〕 | 饮酒史〔例(%)〕 | 高血压〔例(%)〕 | 糖尿病〔例(%)〕 | 冠心病〔例(%)〕 |
---|---|---|---|---|---|---|---|---|
AKI组 | 150 | 81/69 | 73.6±12.6 | 69(46.00) | 25(16.67) | 114(76.00) | 46(30.67) | 40(26.67) |
非AKI组 | 1 052 | 664/388 | 70.7±11.5 | 430(40.87) | 263(25.00) | 760(72.24) | 354(33.65) | 281(26.71) |
检验统计量值 | 4.632 | 2.849a | 1.420 | 5.004 | 0.934 | 0.526 | 0 | |
P值 | 0.031 | 0.004 | 0.233 | 0.025 | 0.334 | 0.468 | 0.991 | |
组别 | 有脑卒中病史〔例(%)〕 | 心房颤动〔例(%)〕 | 脑卒中类型〔例(%)〕 | 入院时NIHSS评分〔M(P25,P75),分〕 | ||||
LAA | SAA | CE | SOE | SUE | ||||
AKI组 | 57(38.00) | 24(16.00) | 55(36.67) | 46(30.67) | 32(21.33) | 1(0.67) | 16(10.67) | 9(4,17) |
非AKI组 | 345(32.79) | 124(11.79) | 359(34.13) | 471(44.77) | 116(11.03) | 13(1.24) | 93(8.84) | 4(2,8) |
检验统计量值 | 1.598 | 2.158 | 18.493 | 7.793b | ||||
P值 | 0.206 | 0.142 | 0.001 | <0.001 |
组别 | 例数 | Hcy(μmol/L) | BUN(mmol/L) | UA(μmol/L) | TC(mmol/L) | TG(mmol/L) | HDL(mmol/L) | LDL(mmol/L) |
---|---|---|---|---|---|---|---|---|
AKI组 | 150 | 22.61±11.86 | 9.21±5.70 | 378.0±144.3 | 4.77±1.49 | 1.62±1.34 | 1.15±0.34 | 3.04±1.19 |
非AKI组 | 1 052 | 17.09±9.48 | 6.09±2.69 | 330.1±99.9 | 4.81±1.17 | 1.61±1.10 | 1.14±1.10 | 3.09±0.95 |
t值 | 5.451 | 6.613 | 3.927 | 0.316 | 0.109 | 0.168 | 0.512 | |
P值 | <0.001 | <0.001 | <0.001 | 0.753 | 0.913 | 0.866 | 0.609 |
Table 2 Comparison of baseline laboratory parameters between AKI group and non-AKI group
组别 | 例数 | Hcy(μmol/L) | BUN(mmol/L) | UA(μmol/L) | TC(mmol/L) | TG(mmol/L) | HDL(mmol/L) | LDL(mmol/L) |
---|---|---|---|---|---|---|---|---|
AKI组 | 150 | 22.61±11.86 | 9.21±5.70 | 378.0±144.3 | 4.77±1.49 | 1.62±1.34 | 1.15±0.34 | 3.04±1.19 |
非AKI组 | 1 052 | 17.09±9.48 | 6.09±2.69 | 330.1±99.9 | 4.81±1.17 | 1.61±1.10 | 1.14±1.10 | 3.09±0.95 |
t值 | 5.451 | 6.613 | 3.927 | 0.316 | 0.109 | 0.168 | 0.512 | |
P值 | <0.001 | <0.001 | <0.001 | 0.753 | 0.913 | 0.866 | 0.609 |
项目 | 回归系数 | 标准误 | Wald χ2值 | P值 | OR值 | 95%CI |
---|---|---|---|---|---|---|
性别(以男性为参照) | -0.377 | 0.176 | 4.595 | 0.032 | 0.686 | (0.486,0.968) |
年龄 | 0.022 | 0.008 | 8.011 | 0.032 | 1.022 | (1.007,1.038) |
吸烟史(以无吸烟史为参照) | 0.209 | 0.175 | 1.417 | 0.234 | 1.232 | (0.874,1.738) |
饮酒史(以无饮酒史为参照) | -0.511 | 0.230 | 4.917 | 0.027 | 0.600 | (0.382,0.942) |
高血压(以无高血压为参照) | 0.196 | 0.203 | 0.931 | 0.334 | 1.217 | (0.817,1.812) |
糖尿病(以无糖尿病为参照) | -0.137 | 0.189 | 0.526 | 0.468 | 0.872 | (0.602,1.262) |
冠心病(以无冠心病为参照) | -0.002 | 0.197 | <0.001 | 0.991 | 0.998 | (0.678,1.469) |
脑卒中病史(以无脑卒中病史为参照) | 0.228 | 0.181 | 1.593 | 0.207 | 1.256 | (0.882,1.789) |
心房颤动(以无心房颤动为参照) | 0.355 | 0.242 | 2.140 | 0.144 | 1.425 | (0.886,2.292) |
脑卒中类型(以LAA为参照) | ||||||
SAA | -0.116 | 0.307 | 0.143 | 0.706 | 0.890 | (0.488,1.625) |
CE | -0.566 | 0.312 | 3.301 | 0.069 | 0.568 | (0.308,1.046) |
SOE | 0.472 | 0.336 | 1.971 | 0.160 | 1.603 | (0.829,3.100) |
SUE | -0.805 | 1.072 | 0.563 | 0.453 | 0.447 | (0.055,3.658) |
入院时NIHSS评分 | 0.094 | 0.012 | 66.288 | <0.001 | 1.098 | (1.074,1.123) |
Hcy | 0.043 | 0.007 | 36.746 | <0.001 | 1.044 | (1.030,1.059) |
BUN | 0.212 | 0.025 | 71.207 | <0.001 | 1.236 | (1.177,1.298) |
UA | 0.004 | 0.001 | 25.085 | <0.001 | 1.004 | (1.002,1.005) |
TC | -0.028 | 0.073 | 0.143 | 0.705 | 0.973 | (0.844,1.122) |
TG | 0.008 | 0.076 | 0.012 | 0.913 | 1.008 | (0.869,1.170) |
HDL | 0.048 | 0.284 | 0.028 | 0.866 | 1.049 | (0.601,1.830) |
LDL | -0.055 | 0.090 | 0.367 | 0.545 | 0.947 | (0.794,1.130) |
Table 3 Univariate Logistic regression analysis of factors associated with AKI after AIS
项目 | 回归系数 | 标准误 | Wald χ2值 | P值 | OR值 | 95%CI |
---|---|---|---|---|---|---|
性别(以男性为参照) | -0.377 | 0.176 | 4.595 | 0.032 | 0.686 | (0.486,0.968) |
年龄 | 0.022 | 0.008 | 8.011 | 0.032 | 1.022 | (1.007,1.038) |
吸烟史(以无吸烟史为参照) | 0.209 | 0.175 | 1.417 | 0.234 | 1.232 | (0.874,1.738) |
饮酒史(以无饮酒史为参照) | -0.511 | 0.230 | 4.917 | 0.027 | 0.600 | (0.382,0.942) |
高血压(以无高血压为参照) | 0.196 | 0.203 | 0.931 | 0.334 | 1.217 | (0.817,1.812) |
糖尿病(以无糖尿病为参照) | -0.137 | 0.189 | 0.526 | 0.468 | 0.872 | (0.602,1.262) |
冠心病(以无冠心病为参照) | -0.002 | 0.197 | <0.001 | 0.991 | 0.998 | (0.678,1.469) |
脑卒中病史(以无脑卒中病史为参照) | 0.228 | 0.181 | 1.593 | 0.207 | 1.256 | (0.882,1.789) |
心房颤动(以无心房颤动为参照) | 0.355 | 0.242 | 2.140 | 0.144 | 1.425 | (0.886,2.292) |
脑卒中类型(以LAA为参照) | ||||||
SAA | -0.116 | 0.307 | 0.143 | 0.706 | 0.890 | (0.488,1.625) |
CE | -0.566 | 0.312 | 3.301 | 0.069 | 0.568 | (0.308,1.046) |
SOE | 0.472 | 0.336 | 1.971 | 0.160 | 1.603 | (0.829,3.100) |
SUE | -0.805 | 1.072 | 0.563 | 0.453 | 0.447 | (0.055,3.658) |
入院时NIHSS评分 | 0.094 | 0.012 | 66.288 | <0.001 | 1.098 | (1.074,1.123) |
Hcy | 0.043 | 0.007 | 36.746 | <0.001 | 1.044 | (1.030,1.059) |
BUN | 0.212 | 0.025 | 71.207 | <0.001 | 1.236 | (1.177,1.298) |
UA | 0.004 | 0.001 | 25.085 | <0.001 | 1.004 | (1.002,1.005) |
TC | -0.028 | 0.073 | 0.143 | 0.705 | 0.973 | (0.844,1.122) |
TG | 0.008 | 0.076 | 0.012 | 0.913 | 1.008 | (0.869,1.170) |
HDL | 0.048 | 0.284 | 0.028 | 0.866 | 1.049 | (0.601,1.830) |
LDL | -0.055 | 0.090 | 0.367 | 0.545 | 0.947 | (0.794,1.130) |
项目 | 模型1 | 模型2 | 模型3 | ||||||
---|---|---|---|---|---|---|---|---|---|
OR值 | 95%CI | P值 | OR值 | 95%CI | P值 | OR值 | 95%CI | P值 | |
Hcy(连续变量) | 1.044 | (1.030,1.059) | <0.001 | 1.046 | (1.031,1.061) | <0.001 | 1.035 | (1.019,1.052) | <0.001 |
Hcy(分类变量,以Hcy正常为参照) | |||||||||
轻型HHcy | 2.487 | (1.681,3.679) | <0.001 | 2.519 | (1.689,3.759) | <0.001 | 1.770 | (1.150,2.724) | 0.009 |
中重型HHcy | 4.021 | (2.414,6.699) | <0.001 | 4.294 | (2.558,7.208) | <0.001 | 2.927 | (1.671,5.126) | <0.001 |
Table 4 Multivariate Logistic regression analysis of Hcy(as a continuous variable or a categorical variable) and AKI after AIS
项目 | 模型1 | 模型2 | 模型3 | ||||||
---|---|---|---|---|---|---|---|---|---|
OR值 | 95%CI | P值 | OR值 | 95%CI | P值 | OR值 | 95%CI | P值 | |
Hcy(连续变量) | 1.044 | (1.030,1.059) | <0.001 | 1.046 | (1.031,1.061) | <0.001 | 1.035 | (1.019,1.052) | <0.001 |
Hcy(分类变量,以Hcy正常为参照) | |||||||||
轻型HHcy | 2.487 | (1.681,3.679) | <0.001 | 2.519 | (1.689,3.759) | <0.001 | 1.770 | (1.150,2.724) | 0.009 |
中重型HHcy | 4.021 | (2.414,6.699) | <0.001 | 4.294 | (2.558,7.208) | <0.001 | 2.927 | (1.671,5.126) | <0.001 |
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