Chinese General Practice ›› 2022, Vol. 25 ›› Issue (24): 2984-2991.DOI: 10.12114/j.issn.1007-9572.2022.0242
• Article • Previous Articles Next Articles
Received:
2022-02-26
Revised:
2022-05-16
Published:
2022-08-20
Online:
2022-06-09
Contact:
Minghang WANG
About author:
通讯作者:
王明航
作者简介:
基金资助:
Add to citation manager EndNote|Ris|BibTeX
URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0242
组别 | 例数 | 年龄( | 过敏性鼻炎〔n(%)〕 | 呼吸系统疾病史〔n(%)〕 | FeNO〔M(P25,P75),ppb〕 |
---|---|---|---|---|---|
NA组 | 84 | 49.9±14.0 | 19(22.6) | 34(40.5) | 29.50(18.25,56.99) |
非NA组 | 100 | 46.2±12.6 | 46(46.0) | 34(34.0) | 56.99(36.25,93.25) |
检验统计量值 | -1.874a | 10.923b | 0.822b | -4.884c | |
P值 | 0.062 | 0.001 | 0.365 | <0.001 |
Table 1 Comparison of clinical data between patients with and without neutrophilic asthma
组别 | 例数 | 年龄( | 过敏性鼻炎〔n(%)〕 | 呼吸系统疾病史〔n(%)〕 | FeNO〔M(P25,P75),ppb〕 |
---|---|---|---|---|---|
NA组 | 84 | 49.9±14.0 | 19(22.6) | 34(40.5) | 29.50(18.25,56.99) |
非NA组 | 100 | 46.2±12.6 | 46(46.0) | 34(34.0) | 56.99(36.25,93.25) |
检验统计量值 | -1.874a | 10.923b | 0.822b | -4.884c | |
P值 | 0.062 | 0.001 | 0.365 | <0.001 |
组别 | 例数 | 年龄( | 过敏性鼻炎〔n(%)〕 | 呼吸系统疾病史〔n(%)〕 | FeNO〔M(P25,P75),ppb〕 |
---|---|---|---|---|---|
EA组 | 38 | 45.9±13.5 | 19(50.0) | 16(42.1) | 62.50(52.25,122.75) |
非EA组 | 146 | 48.4±13.4 | 46(31.5) | 52(35.6) | 40.00(20.00,56.99) |
检验统计量值 | 1.058a | 4.514b | 0.545b | -4.607c | |
P值 | 0.292 | 0.034 | 0.460 | <0.001 |
Table 2 Comparison of clinical data between patients with and without eosinophilic asthma
组别 | 例数 | 年龄( | 过敏性鼻炎〔n(%)〕 | 呼吸系统疾病史〔n(%)〕 | FeNO〔M(P25,P75),ppb〕 |
---|---|---|---|---|---|
EA组 | 38 | 45.9±13.5 | 19(50.0) | 16(42.1) | 62.50(52.25,122.75) |
非EA组 | 146 | 48.4±13.4 | 46(31.5) | 52(35.6) | 40.00(20.00,56.99) |
检验统计量值 | 1.058a | 4.514b | 0.545b | -4.607c | |
P值 | 0.292 | 0.034 | 0.460 | <0.001 |
组别 | 例数 | 年龄( | 过敏性鼻炎〔n(%)〕 | 呼吸系统疾病史〔n(%)〕 | FeNO〔M(P25,P75),ppb〕 |
---|---|---|---|---|---|
MA组 | 38 | 48.8±11.3 | 17(44.7) | 14(36.8) | 57.50(45.00,96.25) |
非MA组 | 146 | 47.7±13.9 | 48(32.9) | 54(40.0) | 42.50(20.00,58.25) |
检验统计量值 | -0.479a | 1.856b | 0.000b | -3.197c | |
P值 | 0.632 | 0.173 | 0.987 | 0.001 |
Table 3 Comparison of clinical data between patients with and without mixed granulocytic asthma
组别 | 例数 | 年龄( | 过敏性鼻炎〔n(%)〕 | 呼吸系统疾病史〔n(%)〕 | FeNO〔M(P25,P75),ppb〕 |
---|---|---|---|---|---|
MA组 | 38 | 48.8±11.3 | 17(44.7) | 14(36.8) | 57.50(45.00,96.25) |
非MA组 | 146 | 47.7±13.9 | 48(32.9) | 54(40.0) | 42.50(20.00,58.25) |
检验统计量值 | -0.479a | 1.856b | 0.000b | -3.197c | |
P值 | 0.632 | 0.173 | 0.987 | 0.001 |
组别 | 例数 | 年龄〔M(P25,P75),岁〕 | 过敏性鼻炎〔n(%)〕 | 呼吸系统疾病史〔n(%)〕 | FeNO〔M(P25,P75),ppb〕 |
---|---|---|---|---|---|
PA组 | 24 | 42.0(34.0,52.8) | 10(41.7) | 4(16.7) | 29.50(19.25,56.99) |
非PA组 | 160 | 50.0(37.2,58.0) | 55(34.4) | 64(40.0) | 55.50(23.00,65.00) |
检验统计量值 | -2.109b | 0.486a | 4.877a | -2.156b | |
P值 | 0.035 | 0.486 | 0.027 | 0.031 |
Table 4 Comparison of clinical data between patients with and without paucigranulocytic asthma
组别 | 例数 | 年龄〔M(P25,P75),岁〕 | 过敏性鼻炎〔n(%)〕 | 呼吸系统疾病史〔n(%)〕 | FeNO〔M(P25,P75),ppb〕 |
---|---|---|---|---|---|
PA组 | 24 | 42.0(34.0,52.8) | 10(41.7) | 4(16.7) | 29.50(19.25,56.99) |
非PA组 | 160 | 50.0(37.2,58.0) | 55(34.4) | 64(40.0) | 55.50(23.00,65.00) |
检验统计量值 | -2.109b | 0.486a | 4.877a | -2.156b | |
P值 | 0.035 | 0.486 | 0.027 | 0.031 |
项目 | B | SE | Wald χ2值 | 自由度 | P值 | OR值 | 95%CI | |
---|---|---|---|---|---|---|---|---|
NA | ||||||||
年龄 | 0.015 | 0.013 | 1.298 | 1 | 0.255 | 1.015 | (0.989,1.041) | |
过敏性鼻炎 | -0.876 | 0.363 | 5.828 | 1 | 0.016 | 0.417 | (0.205,0.848) | |
病程 | 0.002 | 0.001 | 1.553 | 1 | 0.213 | 1.002 | (0.999,1.004) | |
FeNO | -0.022 | 0.006 | 16.097 | 1 | <0.001 | 0.978 | (0.968,0.989) | |
常量 | 0.416 | 0.685 | 0.369 | 1 | 0.544 | 1.516 | — | |
EA | ||||||||
过敏性鼻炎 | 0.604 | 0.404 | 2.241 | 1 | 0.134 | 1.830 | (0.830,4.038) | |
哮喘家族史 | -0.819 | 0.590 | 1.924 | 1 | 0.165 | 0.441 | (0.139,1.403) | |
FeNO | 0.017 | 0.004 | 16.261 | 1 | <0.001 | 1.017 | (1.009,1.025) | |
常量 | -2.532 | 0.390 | 42.105 | 1 | <0.001 | 0.079 | — | |
MA | ||||||||
FeNO | 0.007 | 0.004 | 4.403 | 1 | 0.036 | 1.007 | (1.000,1.014) | |
AQLQ评分 | 0.324 | 0.257 | 1.594 | 1 | 0.207 | 1.383 | (0.836,2.286) | |
常量 | -3.515 | 1.386 | 6.428 | 1 | 0.011 | 0.030 | — | |
PA | ||||||||
年龄 | -0.032 | 0.019 | 2.841 | 1 | 0.092 | 0.969 | (0.933,1.005) | |
BMI | 0.153 | 0.070 | 4.721 | 1 | 0.030 | 1.165 | (1.015,1.337) | |
呼吸系统疾病史 | -1.038 | 0.605 | 2.947 | 1 | 0.086 | 0.354 | (0.108,1.158) | |
FeNO | -0.019 | 0.008 | 4.936 | 1 | 0.026 | 0.981 | (0.965,0.998) | |
LCQ评分 | -0.130 | 0.069 | 3.509 | 1 | 0.061 | 0.878 | (0.766,1.006) | |
常量 | -1.314 | 1.885 | 0.486 | 1 | 0.486 | 0.269 | — |
Table 5 Multivariate Logistic regression analysis of influencing factors of inflammatory phenotypes in asthma
项目 | B | SE | Wald χ2值 | 自由度 | P值 | OR值 | 95%CI | |
---|---|---|---|---|---|---|---|---|
NA | ||||||||
年龄 | 0.015 | 0.013 | 1.298 | 1 | 0.255 | 1.015 | (0.989,1.041) | |
过敏性鼻炎 | -0.876 | 0.363 | 5.828 | 1 | 0.016 | 0.417 | (0.205,0.848) | |
病程 | 0.002 | 0.001 | 1.553 | 1 | 0.213 | 1.002 | (0.999,1.004) | |
FeNO | -0.022 | 0.006 | 16.097 | 1 | <0.001 | 0.978 | (0.968,0.989) | |
常量 | 0.416 | 0.685 | 0.369 | 1 | 0.544 | 1.516 | — | |
EA | ||||||||
过敏性鼻炎 | 0.604 | 0.404 | 2.241 | 1 | 0.134 | 1.830 | (0.830,4.038) | |
哮喘家族史 | -0.819 | 0.590 | 1.924 | 1 | 0.165 | 0.441 | (0.139,1.403) | |
FeNO | 0.017 | 0.004 | 16.261 | 1 | <0.001 | 1.017 | (1.009,1.025) | |
常量 | -2.532 | 0.390 | 42.105 | 1 | <0.001 | 0.079 | — | |
MA | ||||||||
FeNO | 0.007 | 0.004 | 4.403 | 1 | 0.036 | 1.007 | (1.000,1.014) | |
AQLQ评分 | 0.324 | 0.257 | 1.594 | 1 | 0.207 | 1.383 | (0.836,2.286) | |
常量 | -3.515 | 1.386 | 6.428 | 1 | 0.011 | 0.030 | — | |
PA | ||||||||
年龄 | -0.032 | 0.019 | 2.841 | 1 | 0.092 | 0.969 | (0.933,1.005) | |
BMI | 0.153 | 0.070 | 4.721 | 1 | 0.030 | 1.165 | (1.015,1.337) | |
呼吸系统疾病史 | -1.038 | 0.605 | 2.947 | 1 | 0.086 | 0.354 | (0.108,1.158) | |
FeNO | -0.019 | 0.008 | 4.936 | 1 | 0.026 | 0.981 | (0.965,0.998) | |
LCQ评分 | -0.130 | 0.069 | 3.509 | 1 | 0.061 | 0.878 | (0.766,1.006) | |
常量 | -1.314 | 1.885 | 0.486 | 1 | 0.486 | 0.269 | — |
参数 | NA | EA | MA | PA |
---|---|---|---|---|
性别 | -0.088 | 0.101 | -0.007 | 0.018 |
年龄 | 0.134 | -0.074 | 0.038 | -0.156a |
BMI | -0.029 | -0.105 | 0.047 | 0.113 |
吸烟史 | 0.055 | -0.052 | -0.022 | 0.008 |
饮酒史 | -0.083 | 0.010 | 0.042 | 0.059 |
过敏史 | 0.116 | -0.035 | -0.062 | -0.054 |
过敏性鼻炎 | -0.244a | 0.157a | 0.100 | 0.051 |
哮喘家族史 | 0.046 | -0.139 | 0.024 | 0.070 |
呼吸系统疾病史 | 0.067 | 0.054 | -0.001 | -0.163a |
病程 | 0.125 | 0.012 | -0.099 | -0.080 |
ICS治疗史 | -0.091 | 0.054 | 0.082 | -0.029 |
FeNO | -0.361a | 0.341a | 0.236a | -0.159a |
VAS评分 | 0.025 | 0.05 | -0.107 | 0.033 |
ACQ-7评分 | 0.016 | 0.079 | -0.047 | -0.062 |
AQLQ评分 | -0.013 | -0.054 | 0.117 | -0.057 |
LCQ评分 | -0.023 | -0.014 | 0.144 | -0.123 |
CSS评分 | -0.090 | 0.100 | -0.057 | 0.081 |
SAS评分 | -0.041 | 0.062 | -0.029 | 0.021 |
SDS评分 | 0.045 | 0.006 | -0.075 | 0.017 |
Table 6 Spearman rank correlation analysis of inflammatory phenotypes of asthma and associatedfactors
参数 | NA | EA | MA | PA |
---|---|---|---|---|
性别 | -0.088 | 0.101 | -0.007 | 0.018 |
年龄 | 0.134 | -0.074 | 0.038 | -0.156a |
BMI | -0.029 | -0.105 | 0.047 | 0.113 |
吸烟史 | 0.055 | -0.052 | -0.022 | 0.008 |
饮酒史 | -0.083 | 0.010 | 0.042 | 0.059 |
过敏史 | 0.116 | -0.035 | -0.062 | -0.054 |
过敏性鼻炎 | -0.244a | 0.157a | 0.100 | 0.051 |
哮喘家族史 | 0.046 | -0.139 | 0.024 | 0.070 |
呼吸系统疾病史 | 0.067 | 0.054 | -0.001 | -0.163a |
病程 | 0.125 | 0.012 | -0.099 | -0.080 |
ICS治疗史 | -0.091 | 0.054 | 0.082 | -0.029 |
FeNO | -0.361a | 0.341a | 0.236a | -0.159a |
VAS评分 | 0.025 | 0.05 | -0.107 | 0.033 |
ACQ-7评分 | 0.016 | 0.079 | -0.047 | -0.062 |
AQLQ评分 | -0.013 | -0.054 | 0.117 | -0.057 |
LCQ评分 | -0.023 | -0.014 | 0.144 | -0.123 |
CSS评分 | -0.090 | 0.100 | -0.057 | 0.081 |
SAS评分 | -0.041 | 0.062 | -0.029 | 0.021 |
SDS评分 | 0.045 | 0.006 | -0.075 | 0.017 |
[1] |
Global Initiative for Ashma. Global strategy for asthma management and prevention(2021 update)[EB/OL]. [2022-02-15].
|
[2] |
|
[3] |
|
[4] |
Global Initiative for Asthma. Global strategy for asthma management and prevention(2021 update)[EB/OL]. [2022-02-15].
|
[5] |
中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(2016年版)[J]. 中华结核和呼吸杂志,2016,39(9):675-697. DOI:10.3760/cma.j.issn.1001-0939.2016.09.007.
|
[6] |
中华医学会呼吸病学分会哮喘学组.咳嗽的诊断与治疗指南(2015)[J]. 中华结核和呼吸杂志,2016,39(5):323-354. DOI:10.3760/cma.j.issn.1001-0939.2016.05.003.
|
[7] |
|
[8] | |
[9] |
|
[10] |
|
[11] |
|
[12] |
|
[13] |
中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(2020年版)[J]. 中华结核和呼吸杂志,2020,43(12):1023-1048. DOI:10.3760/cma.j.cn112147-20200618-00721.
|
[14] | |
[15] |
|
[16] |
盖晓燕,常春,王娟,等. 中性粒细胞型哮喘患者的气道炎症与小气道重构分析[J]. 北京大学学报:医学版,2018,50(4):645-650. DOI:10.3969/j.issn.1671-167X.2018.04.013.
|
[17] |
|
[18] |
张永明,林江涛,苏楠,等. 支气管哮喘患者气道炎症表型研究[J]. 中华结核和呼吸杂志,2015,38(5):348-351. DOI:10.3760/cma.j.issn.1001-0939.2015.05.007.
|
[19] |
|
[20] |
刘晓燕,施娟. 孟鲁司特钠治疗小儿支气管哮喘合并变应性鼻炎的疗效观察[J]. 中国妇幼保健,2018,33(5):1073-1076. DOI:10.7620/zgfybj.j.issn.1001-4411.2018.05.38.
|
[21] |
|
[22] |
|
[23] |
林月娇. 不同表型哮喘患者上、下气道炎症特征及一致性研究[D]. 广州:广州医科大学,2019.
|
[24] |
陈伟,张勇,王志颐,等. 不同类型鼻炎对下气道炎症的影响[J]. 医学研究生学报,2015,28(2):178-181. DOI:10.16571/j.cnki.1008-8199.2015.02.027.
|
[25] |
|
[26] |
张凤群. 呼出气一氧化氮检测在支气管哮喘诊断中的应用[J]. 世界复合医学,2020,6(9):1-3,32. DOI:10.11966/j.issn.2095-994X.2020.06.09.01.
|
[27] | |
[28] |
|
[29] |
张振花,李文轩,王晓明. 间歇与每日吸入布地奈德对轻度持续性哮喘儿童肺功能及呼出气一氧化氮的影响[J]. 中国当代儿科杂志,2020,22(8):834-838. DOI:10.7499/j.issn.1008-8830.2002170.
|
[30] |
姜慧妍,严思敏,吴秋惠,等. 呼出气一氧化氮指导支气管哮喘患者使用吸入性糖皮质激素治疗效果的研究[J]. 中国医院药学杂志,2021,41(7):696-699. DOI:10.13286/j.1001-5213.2021.07.06.
|
[31] |
李红雯,林江涛. 动态监测呼出气一氧化氮及肺功能在支气管哮喘管理中的应用[J]. 中华健康管理学杂志,2021,15(2):188-190. DOI:10.3760/cma.j.cn115624-20200827-00645.
|
[32] |
彭锦芸. 闽东地区不同人群成人支气管哮喘患者呼出气一氧化氮水平与炎症表型的相关性研究[D]. 福州:福建医科大学,2017.
|
[33] |
赵雪. 哮喘患者呼出气一氧化氮水平与不同气道炎症表型相关性研究[D]. 石家庄:河北医科大学,2019.
|
[34] |
杨瑞虹. 不同炎症表型支气管哮喘患者临床特征的对比研究[J]. 中国医药导刊,2014,16(10):1300-1301,1304. DOI:10.3969/j.issn.1009-0959.2014.10.014.
|
[35] |
刘奕. 不同炎症表型支气管哮喘FeNO检测的临床价值研究[D]. 吉首:吉首大学,2020.
|
[36] |
|
[37] |
|
[38] |
李志伟,马千里,王长征. 支气管哮喘的炎症表型及其临床意义[J]. 中华肺部疾病杂志(电子版),2013,6(4):41-45. DOI:10.3877/cma.j.issn.1674-6902.2013.04.014.
|
[39] |
李志伟,陈华萍,马千里,等. 不同气道炎症表型哮喘278例的临床特征分析[J]. 第三军医大学学报,2013,35(8):801-804. DOI:10.16016/j.1000-5404.2013.08.014.
|
[40] |
|
[41] |
|
[42] |
李志伟,马千里,张巧,等. 急性哮喘气道炎症表型与激素治疗反应性的关系[J]. 第三军医大学学报,2012,34(10):987-990. DOI:10.16016/j.1000-5404.2012.10.016.
|
[1] | QIN Fengyin, ZHANG Qishan, LAI Jinjia, HUANG Yimin, HAN Guoyin, SUN Xinglan, WANG Fen, TAN Yibing. Current Status and Influencing Factors of the Intention to Screen for High-risk Stroke among Community Residents in Guangdong [J]. Chinese General Practice, 2023, 26(34): 4283-4289. |
[2] | HAO Aihua, ZENG Weilin, LI Guanhai, XIA Yinghua, CHEN Liang. Current Situation of the Construction of Family Doctor Team: an Investigation Based on the Perspective of General Practitioners [J]. Chinese General Practice, 2023, 26(34): 4261-4268. |
[3] | LI Dianjiang, PAN Enchun, SUN Zhongming, WEN Jinbo, WANG Miaomiao, WU Ming, SHEN Chong. The Current Status and Influencing Factors of Clinical Inertia in Type 2 Diabetes Patients in Community [J]. Chinese General Practice, 2023, 26(34): 4296-4301. |
[4] | WANG Yue, CHEN Qing, LIU Lurong. Detection Rate of Depression and Its Influencing Factors in Chinese Elderly: a Meta-analysis [J]. Chinese General Practice, 2023, 26(34): 4329-4335. |
[5] | WANG Lina, GAO Pengfei, CAO Fan, GE Ying, YAN Wei, HE Daikun. Analysis of the Prevalence and Influencing Factors of Non-alcoholic Fatty Liver Disease in Different Gender Groups [J]. Chinese General Practice, 2023, 26(33): 4143-4151. |
[6] | ZHANG Jin, DING Zhiguo, QI Shuo, LI Ying, LI Weiqiang, ZHANG Yuanyuan, ZHOU Tong. Relationship between Serum Thyroid Hormone Levels and Prognosis during Hospitalization in Heart Failure Patients [J]. Chinese General Practice, 2023, 26(33): 4125-4129. |
[7] | ZHOU Yuyu, GAO Chuan, CUI Puan, WANG Yaping, HE Zhong. Influencing Factors of Shared Decision Making between Doctors and Patients in Menopausal Hormone Therapy in Patients with Menopausal Syndrome [J]. Chinese General Practice, 2023, 26(33): 4181-4186. |
[8] | LIANG Xuan, NA Feiyang, QIN Mengyao, YANG Hui, GUO Li, GUO Qi, REN Lei, CHEN De, LIU Donghai, ZHANG Rongfang. Clinical Characteristics and Influencing Factors of Bronchial Asthma Combined with Obstructive Sleep Apnea-hypopnea Syndrome in Children [J]. Chinese General Practice, 2023, 26(33): 4225-4230. |
[9] | LI Qianqian, CHEN Xunrui, ZHANG Wenying, YUAN Haihua, ZHANG Yanjie, JIANG Bin, LIU Feng. Demand and Influencing Factors for Community Health Services during Chemotherapy of Patients with Advanced Cancer [J]. Chinese General Practice, 2023, 26(33): 4173-4180. |
[10] | LI Yuan, MU Yanling, XUE Mengzhou. Mechanism of Artesunate Regulating NLRP3/ASC/Caspase-1 Signaling Pathway to Reduce Inflammation and Protect Neurological Function in Mice with Intracerebral Hemorrhage [J]. Chinese General Practice, 2023, 26(33): 4194-4202. |
[11] | GAO Dekang, WEI Shaohua, MA Xiaoming, DU Peng, XING Chungen, CAO Chun. Risk Factors for Loss of Skeletal Muscle Mass and Its Correlation with Complications after Major Hepatectomy for Liver Cancer [J]. Chinese General Practice, 2023, 26(32): 4031-4037. |
[12] | WANG Minghuan, LI Yuhong, YU Min, WANG Yougang, YU Qiaozhi, YANG Fangfang, YUAN Dehui, ZHANG Liu. Effect of Allostatic Load on Adverse Pregnancy Outcomes of Women in Late Pregnancy [J]. Chinese General Practice, 2023, 26(32): 4064-4069. |
[13] | YUAN Dehui, LI Yuhong, XIONG Min, YU Min, MA Ruiliang, YANG Fangfang, YU Qiaozhi, WANG Minghuan. Status and Influencing Factors of Allostatic Load in Pregnant Women at Different Trimesters [J]. Chinese General Practice, 2023, 26(32): 4057-4063. |
[14] | ZHANG Juan, LI Haifen, LI Xiaoman, YAO Miao, MA Huizhen, MA Qiang. Construction of Recurrence Risk Prediction Model for Diabetic Foot Ulcer on the Basis of Logistic Regression, Support Vector Machine and BP Neural Network Model [J]. Chinese General Practice, 2023, 26(32): 4013-4019. |
[15] | GAO Jing, ZHOU Shangcheng, GAO Sande, ZOU Guanyang, CHEN Yingyao. Health-related Quality of Life and Its Influencing Factors in Patients with Prevention of Disease in Traditionnal Chinese Medicine based on EQ-5D-5L Scale [J]. Chinese General Practice, 2023, 26(32): 4043-4050. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||