认知数字疗法干预轻度认知障碍的现状与挑战

doi:10.12114/j.issn.1007-9572.2026.0023

中国全科医学 ›› 2026, Vol. 29 ›› Issue (29): 4211-4216.DOI: 10.12114/j.issn.1007-9572.2026.0023

认知数字疗法干预轻度认知障碍的现状与挑战

穆泓宇¹^,²^,³, 李倩倩¹^,²^,³, 刘璐¹^,²^,³, 孙欣如¹^,²^,³, 张佳琪¹^,²^,³, 段叶青¹^,²^,³^,⁴, 李彬¹^,²^,³^,^*()

1．100010　北京市，首都医科大学附属北京中医医院针灸中心
2．100010　北京市，数智针灸北京市重点实验室
3．100010　北京市，针灸神经调控北京市重点实验室
4．100029　北京市，北京中医药大学研究生院

收稿日期:2026-01-10 修回日期:2026-04-15 出版日期:2026-10-15 发布日期:2026-09-02
通讯作者: 李彬
作者贡献：
穆泓宇负责文章的整体构思、文献检索、论文撰写；李倩倩、刘璐负责文章修订、审校；孙欣如、张佳琪、段叶青负责文章的修改、格式修订；李彬负责文章整体质量控制、对论文监督管理。
基金资助:
北京市科技计划项目——AI+健康协同创新培育项目(Z241100007724008); 北京市"登峰"人才培养计划团队(DFL20241001)

Research Progress and Challenges of Cognitive Digital Therapeutics in the Intervention of Mild Cognitive Impairment

MU Hongyu¹^,²^,³, LI Qianqian¹^,²^,³, LIU Lu¹^,²^,³, SUN Xinru¹^,²^,³, ZHANG Jiaqi¹^,²^,³, DUAN Yeqing¹^,²^,³^,⁴, LI Bin¹^,²^,³^,^*()

1. Acupuncture Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
2. Beijing Key Laboratory of Digital & Intelligent Acupuncture, Beijing 100010, China
3. Beijing Key Laboratory of Acupuncture Neuroregulation, Beijing 100010, China
4. Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China

Received:2026-01-10 Revised:2026-04-15 Published:2026-10-15 Online:2026-09-02
Contact: LI Bin

摘要/Abstract

摘要： 轻度认知障碍（MCI）是痴呆发生前的重要过渡阶段，而目前药物治疗手段有限，亟须可推广的非药物干预措施。认知数字疗法（CDT）是MCI认知训练与长期管理的新型治疗方法。本文综述了CDT用于MCI的临床研究，归纳训练形式、交付载体及其对认知功能的影响，同时总结影像学证据，概括认为其可能通过促进脑结构重塑与功能网络重组发挥作用。在此基础上，重点从依从性评价、随访时间、方案异质性等方面讨论CDT研究中的挑战与问题，并指出AI在个体化适配、监督反馈与远程评估中的潜力。本文认为CDT在MCI长期管理方面具有潜在价值，但需开展更长时期的随访与依从性结局评价，希望为临床实践和未来研究设计提供参考。

关键词: 轻度认知障碍, 认知数字疗法, AI

Abstract:

Mild cognitive impairment (MCI) is a critical transitional stage preceding dementia. With limited pharmacological options available, scalable non-pharmacological interventions are urgently needed. Cognitive digital therapeutics (CDT) represents an emerging approach for cognitive training and long-term management in individuals with MCI. This review summarizes clinical studies of CDT in MCI, synthesizing training modalities, delivery platforms, and their effects on cognitive outcomes. This review also summarizes neuroimaging evidence and highlights potential mechanisms whereby CDT may act through promoting structural brain plasticity and reorganization of functional networks. Building on these findings, this review discusses key challenges in current CDT research, including the lack of adherence assessment, short follow-up durations, and substantial heterogeneity of intervention protocols, and highlights the potential role of artificial intelligence in personalized adaptation, supervised feedback, and remote assessment. Overall, CDT may offer value for long-term MCI management, but longer follow-up studies and standardized adherence-related outcomes are needed to better inform clinical practice and future study design.

Key words: Mild cognitive impairment, Cognitive digital therapeutics, Artificial intelligence

穆泓宇,李倩倩,刘璐,等. 认知数字疗法干预轻度认知障碍的现状与挑战[J]. 中国全科医学, 2026, 29(29): 4211-4216. DOI: 10.12114/j.issn.1007-9572.2026.0023.
MU Hongyu,LI Qianqian,LIU Lu, et al. Research Progress and Challenges of Cognitive Digital Therapeutics in the Intervention of Mild Cognitive Impairment[J]. Chinese General Practice, 2026, 29(29): 4211-4216. DOI: 10.12114/j.issn.1007-9572.2026.0023.

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认知数字疗法干预轻度认知障碍的现状与挑战

Research Progress and Challenges of Cognitive Digital Therapeutics in the Intervention of Mild Cognitive Impairment

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