| [1] | VANCHERI F,LONGO G ,VANCHERI S ,et al. Coronary microvascular dysfunction[J]. J Clin Med ,2020 ,9 (9):2880. DOI:10.3390/jcm9092880 . | 
																													
																						| [2] | CHEN C,WEI J ,ALBADRI A ,et al. Coronary microvascular dysfunction - epidemiology,pathogenesis,prognosis,diagnosis,risk factors and therapy[J]. Circ J ,2016 ,81 (1):3-11. DOI:10.1253/circj.CJ-16-1002 . | 
																													
																						| [3] |  | 
																													
																						| [4] | LU J L,WANG L M ,LI M ,et al. Metabolic syndrome among adults in China:the 2010 China noncommunicable disease surveillance[J]. J Clin Endocrinol Metab ,2017 ,102 (2):507-515. DOI:10.1210/jc.2016-2477 . | 
																													
																						| [5] | LIKOFF W,SEGAL B L ,KASPARIAN H . Paradox of normal selective coronary arteriograms in patients considered to have unmistakable coronary heart disease[J]. N Engl J Med ,1967 ,276 (19):1063-1066. DOI:10.1056/NEJM196705112761904 . | 
																													
																						| [6] | KEMP H G Jr,VOKONAS P S ,COHN P F ,et al. The anginal syndrome associated with normal coronary arteriograms. Report of a six year experience[J]. Am J Med ,1973 ,54 (6):735-742. DOI:10.1016/0002-9343(73)90060-0 . | 
																													
																						| [7] |  | 
																													
																						| [8] | VERHOEFF B J,SIEBES M ,MEUWISSEN M ,et al. Influence of percutaneous coronary intervention on coronary microvascular resistance index[J]. Circulation ,2005 ,111 (1):76-82. DOI:10.1161/01.CIR.0000151610.98409.2F . | 
																													
																						| [9] | CAMICI P G,CREA F . Medical progress-coronary microvascular dysfunction[J]. New England Journal of Medicine ,2007 ,356 (8):830-840. DOI:10.1056/NEJMra061889 . | 
																													
																						| [10] | Task Force Members,MONTALESCOT G ,SECHTEM U ,et al. 2013 ESC guidelines on the management of stable coronary artery disease:the Task Force on the management of stable coronary artery disease of the European Society of Cardiology[J]. Eur Heart J ,2013 ,34 (38):2949-3003. DOI:10.1093/eurheartj/eht296 . | 
																													
																						| [11] | REAVEN G. Banting Lecture 1988. Role of insulin resistance in human disease. 1988[J]. Nutrition ,1997 ,13 (1):65-66. DOI:10.1016/s0899-9007(96)00380-2 . | 
																													
																						| [12] | ZIMMET P Z,MCCARTY D J ,DE COURTEN M P . The global epidemiology of non-insulin-dependent diabetes mellitus and the metabolic syndrome[J]. J Diabetes Complications ,1997 ,11 (2):60-68. DOI:10.1016/s1056-8727(96)00090-6 . | 
																													
																						| [13] |  | 
																													
																						| [14] | Expert Panel on Detection E. Executive summary of the third report of the national cholesterol education program(NCEP)expert panel on detection,evaluation,and treatment of high blood cholesterol in adults(adult treatment panel Ⅲ)[J]. JAMA ,2001 ,285 (19):2486-2497. DOI:10.1001/jama.285.19.2486 . | 
																													
																						| [15] | GRUNDY S M,HANSEN B ,SMITH S C Jr ,et al. Clinical management of metabolic syndrome:report of the American Heart Association/National Heart,Lung,and Blood Institute/American Diabetes Association conference on scientific issues related to management[J]. Arterioscler Thromb Vasc Biol ,2004 ,24 (2):e19-24. DOI:10.1161/01.ATV.0000112379.88385.67 . | 
																													
																						| [16] | ALBERTI K G,ZIMMET P ,SHAW J ,et al. The metabolic syndrome—a new worldwide definition[J]. Lancet ,2005 ,366 (9491):1059-1062. DOI:10.1016/S0140-6736(05)67402-8 . | 
																													
																						| [17] | ALBERTI K G M M,ECKEL R H ,GRUNDY S M ,et al. Harmonizing the metabolic syndrome:a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart,Lung,and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity[J]. Circulation ,2009 ,120 (16):1640-1645. DOI:10.1161/CIRCULATIONAHA.109.192644 . | 
																													
																						| [18] |  | 
																													
																						| [19] | DEFRONZO R A,FERRANNINI E . Insulin resistance. A multifaceted syndrome responsible for NIDDM,obesity,hypertension,dyslipidemia,and atherosclerotic cardiovascular disease[J]. Diabetes Care ,1991 ,14 (3):173-194. DOI:10.2337/diacare.14.3.173 . | 
																													
																						| [20] | NOON J P,WALKER B R ,WEBB D J ,et al. Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure[J]. J Clin Invest ,1997 ,99 (8):1873-1879. DOI:10.1172/JCI119354 . | 
																													
																						| [21] | JONK A M,HOUBEN A J ,DE JONGH R T ,et al. Microvascular dysfunction in obesity:a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension[J]. Physiology ,2007 ,22 :252-260. DOI:10.1152/physiol.00012.2007 . | 
																													
																						| [22] | WALLIS M G,WHEATLEY C M ,RATTIGAN S ,et al. Insulin-mediated hemodynamic changes are impaired in muscle of Zucker obese rats[J]. Diabetes ,2002 ,51 (12):3492-3498. DOI:10.2337/diabetes.51.12.3492 . | 
																													
																						| [23] | SERNÉ E H,GANS R O ,TER MAATEN J C ,et al. Capillary recruitment is impaired in essential hypertension and relates to insulin's metabolic and vascular actions[J]. Cardiovasc Res ,2001 ,49 (1):161-168. DOI:10.1016/s0008-6363(00)00198-x . | 
																													
																						| [24] | WANG R N,LI X ,HUANGFU S H ,et al. Combining body mass index with waist circumference to assess coronary microvascular function in patients with non-obstructive coronary artery disease[J]. J Nucl Cardiol ,2022 ,29 (5):2434-2445. DOI:10.1007/s12350-021-02788-3 . | 
																													
																						| [25] | BAGI Z,BROSKOVA Z ,FEHER A . Obesity and coronary microvascular disease - implications for adipose tissue-mediated remote inflammatory response[J]. Curr Vasc Pharmacol ,2014 ,12 (3):453-461. DOI:10.2174/1570161112666140423221843 . | 
																													
																						| [26] | GLATZ J F C,LUIKEN J J F P . From fat to FAT(CD36/SR-B2):understanding the regulation of cellular fatty acid uptake[J]. Biochimie ,2017 ,136 :21-26. DOI:10.1016/j.biochi.2016.12.007 . | 
																													
																						| [27] | OBRADOVIC M,SUDAR-MILOVANOVIC E ,SOSKIC S ,et al. Leptin and obesity:role and clinical implication[J]. Front Endocrinol ,2021 ,12 :585887. DOI:10.3389/fendo.2021.585887 . | 
																													
																						| [28] | ACHARI A E,JAIN S K . Adiponectin,a therapeutic target for obesity,diabetes,and endothelial dysfunction[J]. Int J Mol Sci ,2017 ,18 (6):1321. DOI:10.3390/ijms18061321 . | 
																													
																						| [29] | KARACA Ü,SCHRAM M T ,HOUBEN A J ,et al. Microvascular dysfunction as a link between obesity,insulin resistance and hypertension[J]. Diabetes Res Clin Pract ,2014 ,103 (3):382-387. DOI:10.1016/j.diabres.2013.12.012 . | 
																													
																						| [30] | OWEN M K,NOBLET J N ,SASSOON D J ,et al. Perivascular adipose tissue and coronary vascular disease[J]. Arterioscler Thromb Vasc Biol ,2014 ,34 (8):1643-1649. DOI:10.1161/ATVBAHA.114.303033 . | 
																													
																						| [31] | COSTA R M,NEVES K B ,TOSTES R C ,et al. Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity[J]. Front Physiol ,2018 ,9 :253. DOI:10.3389/fphys.2018.00253 . | 
																													
																						| [32] | VILLACORTA L,CHANG L . The role of perivascular adipose tissue in vasoconstriction,arterial stiffness,and aneurysm[J]. Horm Mol Biol Clin Investig ,2015 ,21 (2):137-147. DOI:10.1515/hmbci-2014-0048 . | 
																													
																						| [33] | TAQUETI V R,DI CARLI M F . Coronary microvascular disease pathogenic mechanisms and therapeutic options:JACC state-of-the-art review[J]. J Am Coll Cardiol ,2018 ,72 (21):2625-2641. DOI:10.1016/j.jacc.2018.09.042 . | 
																													
																						| [34] | BLOOMGARDEN Z T. Insulin resistance,dyslipidemia,and cardiovascular disease[J]. Diabetes Care ,2007 ,30 (8):2164-2170. DOI:10.2337/dc07-zb08 . | 
																													
																						| [35] | SUN D N,WANG J ,TOAN S ,et al. Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus:focus on mitochondrial quality surveillance[J]. Angiogenesis ,2022 ,25 (3):307-329. DOI:10.1007/s10456-022-09835-8 . | 
																													
																						| [36] | HAYDEN M R. Overview and new insights into the metabolic syndrome:risk factors and emerging variables in the development of type 2 diabetes and cerebrocardiovascular disease[J]. Medicina ,2023 ,59 (3):561. DOI:10.3390/medicina59030561 . | 
																													
																						| [37] | JIA G H,HILL M A ,SOWERS J R . Diabetic cardiomyopathy:an update of mechanisms contributing to this clinical entity[J]. Circ Res ,2018 ,122 (4):624-638. DOI:10.1161/CIRCRESAHA.117.311586 . | 
																													
																						| [38] | SHIVU G N,PHAN T T ,ABOZGUIA K ,et al. Relationship between coronary microvascular dysfunction and cardiac energetics impairment in type 1 diabetes mellitus[J]. Circulation ,2010 ,121 (10):1209-1215. DOI:10.1161/CIRCULATIONAHA.109.873273 . | 
																													
																						| [39] | BUELT A,RICHARDS A,JONES A L. Hypertension:new guidelines from the international society of hypertension[J]. Am Fam Physician,2021,103(12):763-765. | 
																													
																						| [40] | MILLS K T,STEFANESCU A ,HE J . The global epidemiology of hypertension[J]. Nat Rev Nephrol ,2020 ,16 (4):223-237. DOI:10.1038/s41581-019-0244-2 . | 
																													
																						| [41] | BRUNO R M,MASI S ,TADDEI M ,et al. Essential hypertension and functional microvascular ageing[J]. High Blood Press Cardiovasc Prev ,2018 ,25 (1):35-40. DOI:10.1007/s40292-017-0245-9 . | 
																													
																						| [42] | VALENSI P. Autonomic nervous system activity changes in patients with hypertension and overweight:role and therapeutic implications[J]. Cardiovasc Diabetol ,2021 ,20 (1):170. DOI:10.1186/s12933-021-01356-w . | 
																													
																						| [43] | PADRO T,MANFRINI O ,BUGIARDINI R ,et al. ESC Working Group on Coronary Pathophysiology and Microcirculation position paper on 'coronary microvascular dysfunction in cardiovascular disease'[J]. Cardiovasc Res ,2020 ,116 (4):741-755. DOI:10.1093/cvr/cvaa003 . | 
																													
																						| [44] | ALONSO R,MATA P ,ANDRES R D ,et al. Sustained long-term improvement of arterial endothelial function in heterozygous familial hypercholesterolemia patients treated with simvastatin[J]. Atherosclerosis ,2001 ,157 (2):423-429. DOI:10.1016/s0021-9150(00)00733-4 . | 
																													
																						| [45] | REINDL M,REINSTADLER S J ,FEISTRITZER H J ,et al. Relation of low-density lipoprotein cholesterol with microvascular injury and clinical outcome in revascularized ST-elevation myocardial infarction[J]. J Am Heart Assoc ,2017 ,6 (10):e006957. DOI:10.1161/JAHA.117.006957 . | 
																													
																						| [46] | STOKES K Y,CALAHAN L ,RUSSELL J M ,et al. Role of platelets in hypercholesterolemia-induced leukocyte recruitment and arteriolar dysfunction[J]. Microcirculation ,2006 ,13 (5):377-388. DOI:10.1080/10739680600745877 . | 
																													
																						| [47] | SCALIA R,APPEL J Z ,LEFER A M . Leukocyte-endothelium interaction during the early stages of hypercholesterolemia in the rabbit:role of P-selectin,ICAM-1,and VCAM-1[J]. Arterioscler Thromb Vasc Biol ,1998 ,18 (7):1093-1100. DOI:10.1161/01.atv.18.7.1093 . | 
																													
																						| [48] | STOKES K Y,CALAHAN L ,HAMRIC C M ,et al. CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation[J]. Am J Physiol Heart Circ Physiol ,2009 ,296 (3):H689-697. DOI:10.1152/ajpheart.00962.2008 . | 
																													
																						| [49] | STOKES K Y,COOPER D ,TAILOR A ,et al. Hypercholesterolemia promotes inflammation and microvascular dysfunction:role of nitric oxide and superoxide[J]. Free Radic Biol Med ,2002 ,33 (8):1026-1036. DOI:10.1016/s0891-5849(02)01015-8 . | 
																													
																						| [50] | BERLINER J A,LEITINGER N ,TSIMIKAS S . The role of oxidized phospholipids in atherosclerosis[J]. J Lipid Res ,2009 ,50 (Suppl):S207-212. DOI:10.1194/jlr.R800074-JLR200 . | 
																													
																						| [51] | PIRILLO A,NORATA G D ,CATAPANO A L . LOX-1,OxLDL,and atherosclerosis[J]. Mediators Inflamm ,2013 ,2013 :152786. DOI:10.1155/2013/152786 . | 
																													
																						| [52] | SAKURAI K,SAWAMURA T . Stress and vascular responses:endothelial dysfunction via lectin-like oxidized low-density lipoprotein receptor-1:close relationships with oxidative stress[J]. J Pharmacol Sci ,2003 ,91 (3):182-186. DOI:10.1254/jphs.91.182 . | 
																													
																						| [53] | TSIMIKAS S,BRILAKIS E S ,MILLER E R ,et al. Oxidized phospholipids,Lp(a)lipoprotein,and coronary artery disease[J]. N Engl J Med ,2005 ,353 (1):46-57. DOI:10.1056/NEJMoa043175 . | 
																													
																						| [54] | INSTITORIS A,GORDON G R . A tense relationship between capillaries and pericytes[J]. Nat Neurosci ,2021 ,24 (5):615-617. DOI:10.1038/s41593-021-00853-1 . | 
																													
																						| [55] | 倪青.代谢综合征病证结合诊疗指南[J/OL]. [2023-06-19].  | 
																													
																						| [56] | PÉREZ-MARTÍNEZ P,MIKHAILIDIS D P ,ATHYROS V G ,et al. Lifestyle recommendations for the prevention and management of metabolic syndrome:an international panel recommendation[J]. Nutr Rev ,2017 ,75 (5):307-326. DOI:10.1093/nutrit/nux014 . | 
																													
																						| [57] | WIDMER R J,FLAMMER A J ,LERMAN L O ,et al. The Mediterranean diet,its components,and cardiovascular disease[J]. Am J Med ,2015 ,128 (3):229-238. DOI:10.1016/j.amjmed.2014.10.014 . | 
																													
																						| [58] | BACH-FAIG A,BERRY E M ,LAIRON D ,et al. Mediterranean diet pyramid today. Science and cultural updates[J]. Public Health Nutr ,2011 ,14 (12A):2274-2284. DOI:10.1017/S1368980011002515 . | 
																													
																						| [59] | MARTÍNEZ-GONZÁLEZ M A,GEA A ,RUIZ-CANELA M . The Mediterranean diet and cardiovascular health[J]. Circ Res ,2019 ,124 (5):779-798. DOI:10.1161/CIRCRESAHA.118.313348 . | 
																													
																						| [60] | KASTORINI C M,MILIONIS H J ,ESPOSITO K ,et al. The effect of Mediterranean diet on metabolic syndrome and its components:a meta-analysis of 50 studies and 534,906 individuals[J]. J Am Coll Cardiol ,2011 ,57 (11):1299-1313. DOI:10.1016/j.jacc.2010.09.073 . | 
																													
																						| [61] | PAPADAKI A,NOLEN-DOERR E ,MANTZOROS C S . The effect of the Mediterranean diet on metabolic health:a systematic review and meta-analysis of controlled trials in adults[J]. Nutrients ,2020 ,12 (11):3342. DOI:10.3390/nu12113342 . | 
																													
																						| [62] |  | 
																													
																						| [63] | MAO S,ZHANG X X ,CHEN M G ,et al. Beneficial effects of Baduanjin exercise on left ventricular remodelling in patients after acute myocardial infarction:an exploratory clinical trial and proteomic analysis[J]. Cardiovasc Drugs Ther ,2021 ,35 (1):21-32. DOI:10.1007/s10557-020-07047-0 . | 
																													
																						| [64] |  | 
																													
																						| [65] |  | 
																													
																						| [66] |  | 
																													
																						| [67] | BROOKS S,BRANYAN K W ,DEVALLANCE E ,et al. Psychological stress-induced cerebrovascular dysfunction:the role of metabolic syndrome and exercise[J]. Exp Physiol ,2018 ,103 (5):761-776. DOI:10.1113/EP086892 . | 
																													
																						| [68] |  | 
																													
																						| [69] | HAZLETT-STEVENS H,SINGER J ,CHONG A . Mindfulness-based stress reduction and mindfulness-based cognitive therapy with older adults:a qualitative review of randomized controlled outcome research[J]. Clin Gerontol ,2019 ,42 (4):347-358. DOI:10.1080/07317115.2018.1518282 . | 
																													
																						| [70] |  | 
																													
																						| [71] |  | 
																													
																						| [72] | KNUUTI J,WIJNS W ,SARASTE A ,et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes[J]. Eur Heart J ,2020 ,41 (3):407-477. DOI:10.1093/eurheartj/ehz425 . | 
																													
																						| [73] | AMINIAN A,ZAJICHEK A ,ARTERBURN D E ,et al. Association of metabolic surgery with major adverse cardiovascular outcomes in patients with type 2 diabetes and obesity[J]. JAMA ,2019 ,322 (13):1271-1282. DOI:10.1001/jama.2019.14231 . | 
																													
																						| [74] | WU M D,MOCCETTI F ,BROWN E ,et al. Lipoprotein apheresis acutely reverses coronary microvascular dysfunction in patients with severe hypercholesterolemia[J]. JACC Cardiovasc Imaging ,2019 ,12 (8 Pt 1):1430-1440. DOI:10.1016/j.jcmg.2018.05.001 . |