关键词: 睡眠时长, 睡眠问题, TG/HDL-C, 血脂异常, 北京

Abstract: Background　Serum triglyceride to high-density lipoprotein cholesterol（TG/HDL-C） ratio is a systemic indicator of serum lipid levels. Poor sleep may be a risk factor of dyslipidemia. Exploring the association of sleep problems with TG/HDL-C ratio and identifying relevant risk groups，may help to reduce the risk of dyslipidemia via improve sleeping quality. Objective　To examine the sleep quality and its association with TG/HDL-C ratio in Beijing adults in 2017，providing scientific evidence for plasma lipid control via improving sleep quality. Methods　Data were gathered from the 2017 Beijing Non-communicable Disease and Associated Risk Factors Surveillance Program，involving adult permanent residents aged 18-79 years from 16 districts of Beijing selected by multistage stratified sampling and cluster sampling. Demographic information（age，gender，marital status，education level），diagnosis and treatment of chronic diseases（hypertension，diabetes，dyslipidemia），lifestyle（smoking，drinking，and so on），sleep duration and sleep problems〔snoring / suffocation，difficulty falling asleep，awakenings from sleep（≥2），early awakening，use of sleeping pills〕，anthropometric parameters（height，weight，waist circumference and blood pressure），and fasting lipid profile（TC，TG，HDL-C，LDL-C） in venous samples were analyzed. The t-test，Kruskal-Wallis H test，Mann-Whitney U test，chi-square test，and multivariate Logistic regression were used to examine the association of sleep and TG/HDL-C ratio. Results　A total of 13 240 cases were included，with an average age of （44.79±15.47） years and a self-reported average sleep duration of （7.47±1.30） hours/day，and a median TG/HDL-C ratio of 0.99（0.84）. The prevalence of self-reported sleep problems within 30 days was 49.02%（6 490/13 240）. Those who slept 9 hours per day had lowest TG/HDL-C ratio，with a median level of 0.95（0.82）. TG/HDL-C ratio differed significantly in women by the length of sleep（χ2=37.14，P<0.01）. TG/HDL-C ratio differed significantly between those with self-reported sleep problems and those without（P<0.01）. After adjusting for gender，age，marital status，living in urban or rural area，education level，current smoking，drinking within 30 days，insufficient physical activity，hypertension，diabetes，BMI and other potential confounding factors，multivariate Logistic regression analysis showed that at least one kind of sleep problems were associated with elevated TG/HDL-C ratio〔OR=1.05，95%CI（1.01，1.08）〕. Sleep problems were associated with elevated TG/HDL-C ratio in men〔OR=1.05，95%CI（1.01，1.09）〕，and in those aged 18-44〔OR=1.06，95%CI（1.01，1.10）〕. Conclusion　Sleep problems such as too long or too short sleep duration，snoring or suffocation might，difficulty in falling asleep and taking sleeping pills be related to high serum TG/HDL-C ratio among Beijing residents aged 18-79 years. Men and those under 45 years old should be encouraged to take measures to improve their sleep quality.

Key words: Sleep duration, Sleep problems, Triglyceride to HDL cholesterol ratio, Dyslipidemia, Beijing