关键词: 胰腺炎, 囊性纤维化跨膜传导调节因子, 胰蛋白酶, 胰管细胞, 自噬

Abstract: Acute pancreatitis is a inflammatory disease of the pancreas manifested by inappropriate activation of trypsinogen，infiltration of inflammatory cells and destruction of pancreatic secretory cells.It can be life-threatening if the progression reaches an advanced stage.Because the pathogenesis is unclear yet，and there is few efficient clinical treatment for severe acute pancreatitis.Trypsin activation is mostly considered to be the factor associated with the pathogenesis of pancreatitis.During the process，pro-trypsinogen activation is associated with imbalance of trypsin-antitrypsin and genetic heterogeneity.In recent years，many studies revealed that pancreatitis is a multifactorial disease：alcohol and tobacco can injure small pancreatic duct and acinar cells，but the incidence of acute pancreatitis in drinkers is not increased significantly；pancreatic duct secretion can reduce pancreatic injury；some of animal models without trypsinogen activation still get acute pancreatitis；cytokines play an increasingly important role in the prediction of acute pancreatitis；cystic fibrosis transmembrane conductance regulator expression is closely related to the occurrence of severe acute pancreatitis；autophagy also plays an important role in the inflammatory reaction of the pancreas.

Key words: Pancreatitis, Cystic fibrosis transmembrane conductance regulator, Trypsin, Pancreatic duct cells, Autophagy