关键词: 肺炎, 25羟维生素D, 新生儿

Abstract: Objective　To investigate the relationship between serum 25-（OH）D level and neonatal infectious pneumonia.Methods　The participants were all enrolled from the Second Affiliated Hospital of Zhengzhou University from August 2015 to July 2017，including 65 neonates with infectious pneumonia〔pneumonia group （consisting of 34 with mild infectious pneumonia and 31 with severe infectious pneumonia）〕 from the Neonatal Intensive Care Unit，and 60 healthy neonates （control group）. We compared the levels of serum 25-（OH）D，Ca2+，procalcitonin （PCT），C-reactive protein（CRP），and interleukin-6（IL-6） between the controls and neonates with mild infectious pneumonia and those with severe infectious pneumonia. Spearman's rank correlation analysis was performed to investigate the relationships of 25-（OH）D with Ca2+，PCT，CRP and IL-6 in pneumonia group.Results　Serum Ca2+ level did not differ significantly between the controls and mild and severe infectious pneumonia neonates（P>0.05）. However，serum 25-（OH）D，PCT，CRP and IL-6 varied obviously between them（P<0.05），to be specific，the mild and severe infectious pneumonia neonates had lower serum 25-（OH）D
but higher PCT，CRP and IL-6 levels compared with the controls（P<0.05）；neonates with severe infectious pneumonia demonstrated lower serum 25-（OH）D but higher PCT，CRP and IL-6 levels than those with mild infectious pneumonia（P<0.05）.Among the neonates with infectious pneumonia，serum 25-（OH）D was negatively correlated with PCT and IL-6（rs values were -0.434，-0.315；P<0.05），while showed no correlation with Ca2+ and CRP（rs values were -0.053，-0.184；P>0.05）.Conclusion　Decreased serum 25-（OH）D is found in neonates with infectious pneumonia. Moreover，it declines with the aggravation of the disease.Therefore，monitoring serum 25-（OH）D is contributive to the assessment of the severity of neonatal infectious pneumonia.

Key words: Pneumonia；25-hydroxyvitamin D；Infant, newborn