Lifestyle interventions can effectively lower blood glucose levels, promote weight control, improve quality of life, and reduce cardiovascular risk, and constitute a fundamental strategy for the prevention and management of diabetes and other chronic non-communicable diseases. In this context, the American College of Lifestyle Medicine released the Clinical Practice Guideline on Lifestyle Interventions for the Treatment and Remission of Type 2 Diabetes and Prediabetes in Adults, representing the first multidisciplinary clinical practice guideline to position lifestyle intervention as the core therapeutic strategy. Based on available evidence from randomized controlled trials, systematic reviews, and observational studies, the guideline systematically integrates key lifestyle domains, including dietary optimization, promotion of physical activity, sleep management, stress reduction, avoidance of unhealthy substance use, and social support, and establishes a comprehensive management framework encompassing assessment, intervention, follow-up, and dynamic adjustment. The guideline emphasizes patient-centered care and multidisciplinary collaboration, highlights the potential for achieving diabetes remission in selected individuals through intensive lifestyle intervention, and provides principle-based recommendations on medication adjustment and long-term safety monitoring. In addition, practical assessment tools, intervention prescription templates, and follow-up strategies are provided to enhance clinical feasibility. This article interprets the core recommendations of the guideline, focusing on its evidence base, clinical implications, and implementation considerations, with the aim of informing the standardized application of lifestyle interventions in the management of prediabetes and type 2 diabetes in adults.