关键词: 曲坦类药物, 药物毒性, 信号检测, 血管事件, 药品不良反应, 比值比

Abstract: Background　Adverse drug reaction （ADR） is one of the major problems in the field of medicine, which may increase the length of stay, economic burden, and risk of death for hospitalized patients.It may even cause major public health incidents, which seriously threaten life and health.Objective　To detect and analyze the ADR signals of triptans after marketing and provide references for clinical rational drug use.Methods　Reporting odd ratio （ROR） was used to investigate adverse reaction signals of triptans in the Adverse Event Reporting System （AERS） of the Food and Drug Administration of the United States from January 2004 to June 2017, and the results were analyzed and evaluated.Results　Totally 5 531 574 reports were found for all drugs, among which 21 905 reports were mainly induced by seven triptan drugs.A total of 502 ADR signals, of which 35 were serious adverse reaction signals, were mainly related to heart, blood and lymphatic system.The high risk signals with clinical reference mainly included coronarospasm 〔ROR=21.17，95%CI（17.00，26.35）〕, cerebral vasoconstriction 〔ROR=35.32，95%CI（25.27，49.37）〕, variant angina 〔ROR=33.00，95%CI（22.96，47.43）〕, vasospasm 〔ROR=25.29，95%CI（17.38，36.81）〕, artery dissection 〔ROR=22.34，95%CI（12.67，39.38）〕, coronary dissection 〔ROR=15.47，95%CI（8.64，27.70）〕, Raynaud's syndrome 〔ROR=4.31，95%CI（2.96，6.35）〕 and others.Conclusion　Studies on ADR signals in the real world are helpful to evaluate the post-marketing safety of drugs and provide references for drug use in clinical medication.

Key words: Triptans, Drug toxicity, Signal detection, Vascular events, Adverse drug reaction, Odds ratio